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Extraskeletal Ewing sarcoma in a 77-year-old woman.
Arch Pathol Lab Med. 2001 Oct; 125(10):1358-60.AP

Abstract

Extraskeletal Ewing sarcoma (EES) is a rare soft tissue tumor that is morphologically indistinguishable from Ewing sarcoma of bone. It is usually found in young people, but several cases have occurred in patients older than 50 years. The differential diagnoses include other small, blue round cell tumors (SBRCTs) and other members of the Ewing family of tumors such as the primitive neuroectodermal tumor. We present a case of EES in the left inguinal region of a 77-year-old woman. The tumor was distinguished from other SBRCTs by lack of immunoreactivity for epithelial, lymphoid, vascular, neuroendocrine, neural, histiocytic, and muscle markers. Primitive neuroectodermal tumor was excluded because of the lack of neural differentiation by histologic analysis, immunohistochemistry, and electron microscopy. Extraskeletal Ewing sarcoma was confirmed by characteristic features on histologic analysis, histochemistry, immunohistochemistry, and electron microscopy and by the presence of the t(11;22)(q24;q12) fusion transcript detected by reverse transcriptase-polymerase chain reaction. This case serves to remind the reader that EES is not a tumor that occurs exclusively in young patients.

Authors+Show Affiliations

Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11570916

Citation

Cheung, C C., et al. "Extraskeletal Ewing Sarcoma in a 77-year-old Woman." Archives of Pathology & Laboratory Medicine, vol. 125, no. 10, 2001, pp. 1358-60.
Cheung CC, Kandel RA, Bell RS, et al. Extraskeletal Ewing sarcoma in a 77-year-old woman. Arch Pathol Lab Med. 2001;125(10):1358-60.
Cheung, C. C., Kandel, R. A., Bell, R. S., Mathews, R. E., & Ghazarian, D. M. (2001). Extraskeletal Ewing sarcoma in a 77-year-old woman. Archives of Pathology & Laboratory Medicine, 125(10), 1358-60.
Cheung CC, et al. Extraskeletal Ewing Sarcoma in a 77-year-old Woman. Arch Pathol Lab Med. 2001;125(10):1358-60. PubMed PMID: 11570916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extraskeletal Ewing sarcoma in a 77-year-old woman. AU - Cheung,C C, AU - Kandel,R A, AU - Bell,R S, AU - Mathews,R E, AU - Ghazarian,D M, PY - 2001/9/26/pubmed PY - 2002/1/5/medline PY - 2001/9/26/entrez SP - 1358 EP - 60 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 125 IS - 10 N2 - Extraskeletal Ewing sarcoma (EES) is a rare soft tissue tumor that is morphologically indistinguishable from Ewing sarcoma of bone. It is usually found in young people, but several cases have occurred in patients older than 50 years. The differential diagnoses include other small, blue round cell tumors (SBRCTs) and other members of the Ewing family of tumors such as the primitive neuroectodermal tumor. We present a case of EES in the left inguinal region of a 77-year-old woman. The tumor was distinguished from other SBRCTs by lack of immunoreactivity for epithelial, lymphoid, vascular, neuroendocrine, neural, histiocytic, and muscle markers. Primitive neuroectodermal tumor was excluded because of the lack of neural differentiation by histologic analysis, immunohistochemistry, and electron microscopy. Extraskeletal Ewing sarcoma was confirmed by characteristic features on histologic analysis, histochemistry, immunohistochemistry, and electron microscopy and by the presence of the t(11;22)(q24;q12) fusion transcript detected by reverse transcriptase-polymerase chain reaction. This case serves to remind the reader that EES is not a tumor that occurs exclusively in young patients. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/11570916/Extraskeletal_Ewing_sarcoma_in_a_77_year_old_woman_ L2 - https://meridian.allenpress.com/aplm/article-lookup/doi/10.1043/0003-9985(2001)125<1358:EESIAY>2.0.CO;2 DB - PRIME DP - Unbound Medicine ER -