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Three-month comparison of bimatoprost and latanoprost in patients with glaucoma and ocular hypertension.
Adv Ther 2001 May-Jun; 18(3):110-21AT

Abstract

A multicenter, randomized, investigator-masked, parallel-group trial compared bimatoprost and latanoprost for efficacy and safety in patients with glaucoma or ocular hypertension. Patients received bimatoprost 0.03% (n = 119) or latanoprost 0.005% (n = 113) once daily in the evening for 3 months. Visits were at prestudy, baseline (day 0), week 1, and months 1, 2, and 3. Primary outcome measures were mean IOP and the percentage of patients achieving IOP of 17 mm Hg or lower at 8:00 AM. Secondary outcome measures were diurnal IOP measurements (8:00 AM, 12 noon, 4:00 PM, 8:00 PM) at month 3 and safety measures including adverse events. Mean IOP was lower with bimatoprost than with latanoprost at all time points during the 3-month follow-up, although the between-group difference was not always statistically significant. At month 3 at 12 noon, mean IOP was as much as 1.0 mm Hg lower with bimatoprost (P = .021). Target pressures of < or = 17 mm Hg were reached more often with bimatoprost than with latanoprost at 8:00 AM (53% vs 43%; P = .029). Over all diurnal measurements at month 3, low target pressures of < or = 13, < or = 14, and < or = 15 mm Hg were achieved significantly more often with bimatoprost (P < or = .006). Both drugs were safe and well tolerated. Conjunctival hyperemia was more common with bimatoprost, while headache was more frequent with latanoprost. Bimatoprost provided lower mean pressures than latanoprost at every time point throughout the study and was statistically superior in achieving low target pressures. More patients reached low target pressures with bimatoprost.

Authors+Show Affiliations

University of Parma, Via Gramsci 14, Parma, 43100, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

11571823

Citation

Gandolfi, S, et al. "Three-month Comparison of Bimatoprost and Latanoprost in Patients With Glaucoma and Ocular Hypertension." Advances in Therapy, vol. 18, no. 3, 2001, pp. 110-21.
Gandolfi S, Simmons ST, Sturm R, et al. Three-month comparison of bimatoprost and latanoprost in patients with glaucoma and ocular hypertension. Adv Ther. 2001;18(3):110-21.
Gandolfi, S., Simmons, S. T., Sturm, R., Chen, K., & VanDenburgh, A. M. (2001). Three-month comparison of bimatoprost and latanoprost in patients with glaucoma and ocular hypertension. Advances in Therapy, 18(3), pp. 110-21.
Gandolfi S, et al. Three-month Comparison of Bimatoprost and Latanoprost in Patients With Glaucoma and Ocular Hypertension. Adv Ther. 2001;18(3):110-21. PubMed PMID: 11571823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-month comparison of bimatoprost and latanoprost in patients with glaucoma and ocular hypertension. AU - Gandolfi,S, AU - Simmons,S T, AU - Sturm,R, AU - Chen,K, AU - VanDenburgh,A M, AU - ,, PY - 2001/9/27/pubmed PY - 2001/10/19/medline PY - 2001/9/27/entrez SP - 110 EP - 21 JF - Advances in therapy JO - Adv Ther VL - 18 IS - 3 N2 - A multicenter, randomized, investigator-masked, parallel-group trial compared bimatoprost and latanoprost for efficacy and safety in patients with glaucoma or ocular hypertension. Patients received bimatoprost 0.03% (n = 119) or latanoprost 0.005% (n = 113) once daily in the evening for 3 months. Visits were at prestudy, baseline (day 0), week 1, and months 1, 2, and 3. Primary outcome measures were mean IOP and the percentage of patients achieving IOP of 17 mm Hg or lower at 8:00 AM. Secondary outcome measures were diurnal IOP measurements (8:00 AM, 12 noon, 4:00 PM, 8:00 PM) at month 3 and safety measures including adverse events. Mean IOP was lower with bimatoprost than with latanoprost at all time points during the 3-month follow-up, although the between-group difference was not always statistically significant. At month 3 at 12 noon, mean IOP was as much as 1.0 mm Hg lower with bimatoprost (P = .021). Target pressures of < or = 17 mm Hg were reached more often with bimatoprost than with latanoprost at 8:00 AM (53% vs 43%; P = .029). Over all diurnal measurements at month 3, low target pressures of < or = 13, < or = 14, and < or = 15 mm Hg were achieved significantly more often with bimatoprost (P < or = .006). Both drugs were safe and well tolerated. Conjunctival hyperemia was more common with bimatoprost, while headache was more frequent with latanoprost. Bimatoprost provided lower mean pressures than latanoprost at every time point throughout the study and was statistically superior in achieving low target pressures. More patients reached low target pressures with bimatoprost. SN - 0741-238X UR - https://www.unboundmedicine.com/medline/citation/11571823/Three_month_comparison_of_bimatoprost_and_latanoprost_in_patients_with_glaucoma_and_ocular_hypertension_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=11571823.ui DB - PRIME DP - Unbound Medicine ER -