Tags

Type your tag names separated by a space and hit enter

Effects of soy phytoestrogens genistein and daidzein on breast cancer growth.
Ann Pharmacother 2001; 35(9):1118-21AP

Abstract

OBJECTIVE

To determine whether genistein and daidzein, the major phytoestrogens in soy, can stimulate breast cancer growth.

DATA SYNTHESIS

Systematic search through primary English-language literature on MEDLINE (1966-January 2001), EMBASE (1982-January 2001) and Current Contents (1998-January 2001).

DATA SOURCES

Genistein and daidzein at low concentrations were found to stimulate breast tumor growth in in vitro and in vivo animal studies, and antagonize the antitumor effect of tamoxifen in vitro. At high concentrations, genistein inhibited tumor growth and enhanced the effect of tamoxifen in vitro.

CONCLUSIONS

Genistein and daidzein may stimulate existing breast tumor growth and antagonize the effects of tamoxifen. Women with current or past breast cancer should be aware of the risks of potential tumor growth when taking soy products.

Authors+Show Affiliations

Provincial Systemic Therapy Program, British Columbia Cancer Agency, Vancouver, Canada. mdelemos@bccancer.bc.ca

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11573864

Citation

de Lemos, M L.. "Effects of Soy Phytoestrogens Genistein and Daidzein On Breast Cancer Growth." The Annals of Pharmacotherapy, vol. 35, no. 9, 2001, pp. 1118-21.
de Lemos ML. Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. Ann Pharmacother. 2001;35(9):1118-21.
de Lemos, M. L. (2001). Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. The Annals of Pharmacotherapy, 35(9), pp. 1118-21.
de Lemos ML. Effects of Soy Phytoestrogens Genistein and Daidzein On Breast Cancer Growth. Ann Pharmacother. 2001;35(9):1118-21. PubMed PMID: 11573864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. A1 - de Lemos,M L, PY - 2001/9/28/pubmed PY - 2002/2/6/medline PY - 2001/9/28/entrez SP - 1118 EP - 21 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 35 IS - 9 N2 - OBJECTIVE: To determine whether genistein and daidzein, the major phytoestrogens in soy, can stimulate breast cancer growth. DATA SYNTHESIS: Systematic search through primary English-language literature on MEDLINE (1966-January 2001), EMBASE (1982-January 2001) and Current Contents (1998-January 2001). DATA SOURCES: Genistein and daidzein at low concentrations were found to stimulate breast tumor growth in in vitro and in vivo animal studies, and antagonize the antitumor effect of tamoxifen in vitro. At high concentrations, genistein inhibited tumor growth and enhanced the effect of tamoxifen in vitro. CONCLUSIONS: Genistein and daidzein may stimulate existing breast tumor growth and antagonize the effects of tamoxifen. Women with current or past breast cancer should be aware of the risks of potential tumor growth when taking soy products. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/11573864/Effects_of_soy_phytoestrogens_genistein_and_daidzein_on_breast_cancer_growth_ L2 - http://journals.sagepub.com/doi/full/10.1345/aph.10257?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -