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The -174/-597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis.
J Neurol Sci 2001; 190(1-2):69-72JN

Abstract

Interleukin-6 (IL-6) has been implicated in the etiology of experimental autoimmune encephalomyelitis (EAE) in transgenic animals and contributes to neuropathology in humans. A single nucleotide polymorphism (SNP) at position -174 in the IL-6 gene promoter (IL-6pr) appears to influence IL-6 expression. Complete linkage disequilibrium was observed between the -174 and the -597 alleles. The aim of this study was to investigate the possible influence of -174/-597 IL-6pr polymorphisms on susceptibility to multiple sclerosis (MS). Genotyping of the -597 variant was performed by an RFLP method in 131 MS patients [88 relapsing-remitting (RR-MS), 43 secondary progressive (SP-MS)] and 157 healthy subjects. No differences were found between MS patients and controls with respect to the distribution of -597 IL-6pr genotypes. Neither was found when genotypes were analyzed according to the clinical course of the disease (RR-MS or SP-MS). Future studies focusing on complex transcriptional interactions between the IL-6pr and 3' flanking region polymorphic sites will be necessary to determine the IL-6 haplotype influence on susceptibility to MS.

Authors+Show Affiliations

Instituto de Parasitología y Biomedicina López Neyra, CSIC, Calle Ventanilla 11, 18001, Granada, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11574109

Citation

Fedetz, M, et al. "The -174/-597 Promoter Polymorphisms in the Interleukin-6 Gene Are Not Associated With Susceptibility to Multiple Sclerosis." Journal of the Neurological Sciences, vol. 190, no. 1-2, 2001, pp. 69-72.
Fedetz M, Matesanz F, Pascual M, et al. The -174/-597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis. J Neurol Sci. 2001;190(1-2):69-72.
Fedetz, M., Matesanz, F., Pascual, M., Martín, J., Fernández, O., Guerrero, M., & Alcina, A. (2001). The -174/-597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis. Journal of the Neurological Sciences, 190(1-2), pp. 69-72.
Fedetz M, et al. The -174/-597 Promoter Polymorphisms in the Interleukin-6 Gene Are Not Associated With Susceptibility to Multiple Sclerosis. J Neurol Sci. 2001 Sep 15;190(1-2):69-72. PubMed PMID: 11574109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The -174/-597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis. AU - Fedetz,M, AU - Matesanz,F, AU - Pascual,M, AU - Martín,J, AU - Fernández,O, AU - Guerrero,M, AU - Alcina,A, PY - 2001/9/28/pubmed PY - 2002/1/5/medline PY - 2001/9/28/entrez SP - 69 EP - 72 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 190 IS - 1-2 N2 - Interleukin-6 (IL-6) has been implicated in the etiology of experimental autoimmune encephalomyelitis (EAE) in transgenic animals and contributes to neuropathology in humans. A single nucleotide polymorphism (SNP) at position -174 in the IL-6 gene promoter (IL-6pr) appears to influence IL-6 expression. Complete linkage disequilibrium was observed between the -174 and the -597 alleles. The aim of this study was to investigate the possible influence of -174/-597 IL-6pr polymorphisms on susceptibility to multiple sclerosis (MS). Genotyping of the -597 variant was performed by an RFLP method in 131 MS patients [88 relapsing-remitting (RR-MS), 43 secondary progressive (SP-MS)] and 157 healthy subjects. No differences were found between MS patients and controls with respect to the distribution of -597 IL-6pr genotypes. Neither was found when genotypes were analyzed according to the clinical course of the disease (RR-MS or SP-MS). Future studies focusing on complex transcriptional interactions between the IL-6pr and 3' flanking region polymorphic sites will be necessary to determine the IL-6 haplotype influence on susceptibility to MS. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/11574109/The__174/_597_promoter_polymorphisms_in_the_interleukin_6_gene_are_not_associated_with_susceptibility_to_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022510X01005950 DB - PRIME DP - Unbound Medicine ER -