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Comparative safety of the different macrolides.
Int J Antimicrob Agents. 2001; 18 Suppl 1:S71-6.IJ

Abstract

The macrolides are generally well tolerated when used for the treatment of acute infections. Even when given long term for prophylaxis, there are few discontinuations due to side-effects. There are isolated reports of QT(c) prolongation in patients treated with erythromycin and other 14-membered-ring macrolides. Since the 14-membered-ring macrolides are metabolized by P450 isoenzymes, there is the potential for interaction with other therapeutic agents also metabolized in this way. Pharmacokinetic studies have demonstrated interactions between either erythromycin or clarithromycin and cyclosporin, cisapride, pimozide, disopyramide, astemizole, carbamazepine, midazolam, digoxin, hydroxymethylglutaryl-coenzyme A reductase inhibitors (i.e. 'statins') and warfarin. In patients receiving such concurrent therapy, azithromycin may be superior to erythromycin and clarithromycin.

Authors+Show Affiliations

Infectious Diseases Unit, Chaim Sheba Medical Center, Tel Aviv University School of Medicine, IL-52621 Tel-Hashomer, Israel. erubins@yahoo.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11574199

Citation

Rubinstein, E. "Comparative Safety of the Different Macrolides." International Journal of Antimicrobial Agents, vol. 18 Suppl 1, 2001, pp. S71-6.
Rubinstein E. Comparative safety of the different macrolides. Int J Antimicrob Agents. 2001;18 Suppl 1:S71-6.
Rubinstein, E. (2001). Comparative safety of the different macrolides. International Journal of Antimicrobial Agents, 18 Suppl 1, S71-6.
Rubinstein E. Comparative Safety of the Different Macrolides. Int J Antimicrob Agents. 2001;18 Suppl 1:S71-6. PubMed PMID: 11574199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative safety of the different macrolides. A1 - Rubinstein,E, PY - 2001/9/28/pubmed PY - 2002/4/19/medline PY - 2001/9/28/entrez SP - S71 EP - 6 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 18 Suppl 1 N2 - The macrolides are generally well tolerated when used for the treatment of acute infections. Even when given long term for prophylaxis, there are few discontinuations due to side-effects. There are isolated reports of QT(c) prolongation in patients treated with erythromycin and other 14-membered-ring macrolides. Since the 14-membered-ring macrolides are metabolized by P450 isoenzymes, there is the potential for interaction with other therapeutic agents also metabolized in this way. Pharmacokinetic studies have demonstrated interactions between either erythromycin or clarithromycin and cyclosporin, cisapride, pimozide, disopyramide, astemizole, carbamazepine, midazolam, digoxin, hydroxymethylglutaryl-coenzyme A reductase inhibitors (i.e. 'statins') and warfarin. In patients receiving such concurrent therapy, azithromycin may be superior to erythromycin and clarithromycin. SN - 0924-8579 UR - https://www.unboundmedicine.com/medline/citation/11574199/Comparative_safety_of_the_different_macrolides_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924857901003971 DB - PRIME DP - Unbound Medicine ER -