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Association between nonpsychotic psychiatric diagnoses in adolescent males and subsequent onset of schizophrenia.
Arch Gen Psychiatry. 2001 Oct; 58(10):959-64.AG

Abstract

BACKGROUND

Nonpsychotic psychiatric symptoms may occasionally herald the later development of schizophrenia. This study followed a population-based cohort of adolescents with nonpsychotic, non-major affective psychiatric disorders to ascertain future hospitalization for schizophrenia.

METHODS

Results of the medical and mental health assessments on 124 24416- to 17-year-old males screened by the Israeli draft board were cross-linked with the National Psychiatric Hospitalization case registry, which contains data on all psychiatric hospitalizations in the country, during a 4- to 8-year-long follow-up through age 25 years. In the cohort, 9365 adolescents were assigned a nonpsychotic, non-major affective diagnosis by the draft board.

RESULTS

After excluding 167 adolescents who were hospitalized before or up to 1 year after the draft board assessment, 1.03% of the adolescents assigned a nonpsychotic, non-major affective psychiatric diagnosis, compared with only 0.23% of the adolescents without any psychiatric diagnosis, were later hospitalized for schizophrenia. Of the patients with schizophrenia, 26.8%, compared with only 7.4% in the general population, had been assigned a nonpsychotic, non-major affective psychiatric diagnosis in adolescence (overall odds ratio [OR], 4.5; 95% confidence interval [CI], 3.6-5.6), ranging from OR, 21.5 (95% CI, 12.6-36.6) for schizophrenia spectrum personality disorders to OR, 3.6 (95% CI, 2.1-6.2) for neurosis.

CONCLUSION

These results reflect the relatively common finding of impaired functioning in patients later hospitalized for schizophrenia and the relatively low power of these disorders in predicting schizophrenia.

Authors+Show Affiliations

Chaim Sheba Medical Center, Tel-Aviv University, Tel-Hashomer 52621, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11576035

Citation

Weiser, M, et al. "Association Between Nonpsychotic Psychiatric Diagnoses in Adolescent Males and Subsequent Onset of Schizophrenia." Archives of General Psychiatry, vol. 58, no. 10, 2001, pp. 959-64.
Weiser M, Reichenberg A, Rabinowitz J, et al. Association between nonpsychotic psychiatric diagnoses in adolescent males and subsequent onset of schizophrenia. Arch Gen Psychiatry. 2001;58(10):959-64.
Weiser, M., Reichenberg, A., Rabinowitz, J., Kaplan, Z., Mark, M., Bodner, E., Nahon, D., & Davidson, M. (2001). Association between nonpsychotic psychiatric diagnoses in adolescent males and subsequent onset of schizophrenia. Archives of General Psychiatry, 58(10), 959-64.
Weiser M, et al. Association Between Nonpsychotic Psychiatric Diagnoses in Adolescent Males and Subsequent Onset of Schizophrenia. Arch Gen Psychiatry. 2001;58(10):959-64. PubMed PMID: 11576035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between nonpsychotic psychiatric diagnoses in adolescent males and subsequent onset of schizophrenia. AU - Weiser,M, AU - Reichenberg,A, AU - Rabinowitz,J, AU - Kaplan,Z, AU - Mark,M, AU - Bodner,E, AU - Nahon,D, AU - Davidson,M, PY - 2001/11/1/pubmed PY - 2001/11/3/medline PY - 2001/11/1/entrez SP - 959 EP - 64 JF - Archives of general psychiatry JO - Arch Gen Psychiatry VL - 58 IS - 10 N2 - BACKGROUND: Nonpsychotic psychiatric symptoms may occasionally herald the later development of schizophrenia. This study followed a population-based cohort of adolescents with nonpsychotic, non-major affective psychiatric disorders to ascertain future hospitalization for schizophrenia. METHODS: Results of the medical and mental health assessments on 124 24416- to 17-year-old males screened by the Israeli draft board were cross-linked with the National Psychiatric Hospitalization case registry, which contains data on all psychiatric hospitalizations in the country, during a 4- to 8-year-long follow-up through age 25 years. In the cohort, 9365 adolescents were assigned a nonpsychotic, non-major affective diagnosis by the draft board. RESULTS: After excluding 167 adolescents who were hospitalized before or up to 1 year after the draft board assessment, 1.03% of the adolescents assigned a nonpsychotic, non-major affective psychiatric diagnosis, compared with only 0.23% of the adolescents without any psychiatric diagnosis, were later hospitalized for schizophrenia. Of the patients with schizophrenia, 26.8%, compared with only 7.4% in the general population, had been assigned a nonpsychotic, non-major affective psychiatric diagnosis in adolescence (overall odds ratio [OR], 4.5; 95% confidence interval [CI], 3.6-5.6), ranging from OR, 21.5 (95% CI, 12.6-36.6) for schizophrenia spectrum personality disorders to OR, 3.6 (95% CI, 2.1-6.2) for neurosis. CONCLUSION: These results reflect the relatively common finding of impaired functioning in patients later hospitalized for schizophrenia and the relatively low power of these disorders in predicting schizophrenia. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/11576035/Association_between_nonpsychotic_psychiatric_diagnoses_in_adolescent_males_and_subsequent_onset_of_schizophrenia_ L2 - https://jamanetwork.com/journals/jamapsychiatry/fullarticle/vol/58/pg/959 DB - PRIME DP - Unbound Medicine ER -