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Exercise and oxidative stress: significance of antioxidants with reference to inflammatory, muscular, and systemic stress.

Abstract

Many studies have demonstrated that intense muscular work generates considerable amounts of reactive oxygen species (ROS). In order to prevent oxidative stress, the body contains a large number of nonenzymatic and enzymatic antioxidants that either prevent ROS formation or scavenge radical species. Oxidative stress can lead to damage or destruction of cellular macromolecules such as lipids, proteins, and nucleic acids. Therefore, oxidative stress has been associated with decreased physical performance, muscular fatigue, muscle damage, and overtraining. It has been hypothesized that the body's physiological amount of antioxidants is not sufficient to prevent exercise-induced oxidative stress and that additional antioxidants are needed to reduce oxidative stress, muscular damage, or overshooting inflammation. However, some but not all investigations have demonstrated oxidative stress following physical exercise, and also, findings concerning the role of antioxidants in reducing oxidative stress are equivocal. In addition, a clear association between the amount of exercise-induced muscular, metabolic, hormonal, or inflammatory stress and levels of antioxidant vitamins could not be established consistently. Therefore, although the theoretical background may be sound, there is no scientific evidence to recommend increased quantities of antioxidants to physically active people exceeding the amount provided by a healthy, balanced nutrition.

Authors+Show Affiliations

,

Center for Internal Medicine, Department of Rehabilitation, Prevention, and Sports Medicine, Freiburg University Hospital, Germany. Dani@msm1.uk1.uni-freiburg.de

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Source

Exercise immunology review 7: 2001 pg 108-33

MeSH

Animals
Antioxidants
Exercise
Humans
Inflammation Mediators
Myoglobin
Myositis
Oxidative Stress
Reactive Oxygen Species
Sports
Stress, Mechanical

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11579745

Citation

König, D, et al. "Exercise and Oxidative Stress: Significance of Antioxidants With Reference to Inflammatory, Muscular, and Systemic Stress." Exercise Immunology Review, vol. 7, 2001, pp. 108-33.
König D, Wagner KH, Elmadfa I, et al. Exercise and oxidative stress: significance of antioxidants with reference to inflammatory, muscular, and systemic stress. Exerc Immunol Rev. 2001;7:108-33.
König, D., Wagner, K. H., Elmadfa, I., & Berg, A. (2001). Exercise and oxidative stress: significance of antioxidants with reference to inflammatory, muscular, and systemic stress. Exercise Immunology Review, 7, pp. 108-33.
König D, et al. Exercise and Oxidative Stress: Significance of Antioxidants With Reference to Inflammatory, Muscular, and Systemic Stress. Exerc Immunol Rev. 2001;7:108-33. PubMed PMID: 11579745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise and oxidative stress: significance of antioxidants with reference to inflammatory, muscular, and systemic stress. AU - König,D, AU - Wagner,K H, AU - Elmadfa,I, AU - Berg,A, PY - 2001/10/3/pubmed PY - 2002/2/14/medline PY - 2001/10/3/entrez SP - 108 EP - 33 JF - Exercise immunology review JO - Exerc Immunol Rev VL - 7 N2 - Many studies have demonstrated that intense muscular work generates considerable amounts of reactive oxygen species (ROS). In order to prevent oxidative stress, the body contains a large number of nonenzymatic and enzymatic antioxidants that either prevent ROS formation or scavenge radical species. Oxidative stress can lead to damage or destruction of cellular macromolecules such as lipids, proteins, and nucleic acids. Therefore, oxidative stress has been associated with decreased physical performance, muscular fatigue, muscle damage, and overtraining. It has been hypothesized that the body's physiological amount of antioxidants is not sufficient to prevent exercise-induced oxidative stress and that additional antioxidants are needed to reduce oxidative stress, muscular damage, or overshooting inflammation. However, some but not all investigations have demonstrated oxidative stress following physical exercise, and also, findings concerning the role of antioxidants in reducing oxidative stress are equivocal. In addition, a clear association between the amount of exercise-induced muscular, metabolic, hormonal, or inflammatory stress and levels of antioxidant vitamins could not be established consistently. Therefore, although the theoretical background may be sound, there is no scientific evidence to recommend increased quantities of antioxidants to physically active people exceeding the amount provided by a healthy, balanced nutrition. SN - 1077-5552 UR - https://www.unboundmedicine.com/medline/citation/11579745/Exercise_and_oxidative_stress:_significance_of_antioxidants_with_reference_to_inflammatory_muscular_and_systemic_stress_ L2 - https://medlineplus.gov/myositis.html DB - PRIME DP - Unbound Medicine ER -