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Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism.
Thromb Haemost. 2001 Sep; 86(3):809-16.TH

Abstract

Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors involved in venous thromboembolism (VTE). The goal of this pooled analysis of 8 case-control studies, comprising a total of 2310 cases and 3204 controls, was to precisely estimate the risk of VTE in patients bearing both mutations (double heterozygotes). Odds ratios for VTE were 4.9 (95% CI; 4.1-5.9) for the factor V Leiden and 3.8 (3.0-4.9) for the factor II G20210A mutation. Fifty-one cases (2.2%) and none of the controls were double heterozygotes. The odds ratio for venous thrombosis in double heterozygotes was 20.0 (11.1-36.1). Twelve percent of patients heterozygous for factor V Leiden were also heterozygous for factor II G20210A and conversely 23% of patients heterozygous for factor II G20210A were also heterozygous for factor V Leiden. Furthermore, in this large population we analyzed the effect of oral contraceptive (OC) in women carrying one of these mutations. Odds ratio for VTE associated with OC was 2.29 (1.72-3.04). In factor V Leiden carriers using OC, the odds ratio for VTE was 10.25 (5.69-1 8.45). The odds ratio of the association of factor II mutation and OC use was 7.14 (3.39-15.04). Finally, we also confirmed that the frequency of factor V Leiden was lower in patients with pulmonary embolism than in patients with deep vein thrombosis without PE (odds ratio 0.69). Conversely, factor II G20210A mutation was equally balanced in both patient groups.

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Authors+Show Affiliations

Emmerich J
Hôpital Européen Georges Pompidou, Service de Médecine Vasculaire, Centre Claude Bernard et Laboratoire d'Hémostase, Paris, France. joseph.emmerich@egp.ap-hop-paris.fr
Rosendaal FR
No affiliation info available
Cattaneo M
No affiliation info available
Margaglione M
No affiliation info available
De Stefano V
No affiliation info available
Cumming T
No affiliation info available
Arruda V
No affiliation info available
Hillarp A
No affiliation info available
Reny JL
No affiliation info available

MeSH

3' Untranslated RegionsActivated Protein C ResistanceAdolescentAdultCase-Control StudiesContraceptives, Oral, HormonalEuropeFactor VFemaleHeterozygoteHumansMaleMiddle AgedPoint MutationProthrombinPulmonary EmbolismRiskThrombophiliaVenous Thrombosis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11583312

Citation

Emmerich, J, et al. "Combined Effect of Factor V Leiden and Prothrombin 20210A On the Risk of Venous Thromboembolism--pooled Analysis of 8 Case-control Studies Including 2310 Cases and 3204 Controls. Study Group for Pooled-Analysis in Venous Thromboembolism." Thrombosis and Haemostasis, vol. 86, no. 3, 2001, pp. 809-16.
Emmerich J, Rosendaal FR, Cattaneo M, et al. Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. Thromb Haemost. 2001;86(3):809-16.
Emmerich, J., Rosendaal, F. R., Cattaneo, M., Margaglione, M., De Stefano, V., Cumming, T., Arruda, V., Hillarp, A., & Reny, J. L. (2001). Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. Thrombosis and Haemostasis, 86(3), 809-16.
Emmerich J, et al. Combined Effect of Factor V Leiden and Prothrombin 20210A On the Risk of Venous Thromboembolism--pooled Analysis of 8 Case-control Studies Including 2310 Cases and 3204 Controls. Study Group for Pooled-Analysis in Venous Thromboembolism. Thromb Haemost. 2001;86(3):809-16. PubMed PMID: 11583312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. AU - Emmerich,J, AU - Rosendaal,F R, AU - Cattaneo,M, AU - Margaglione,M, AU - De Stefano,V, AU - Cumming,T, AU - Arruda,V, AU - Hillarp,A, AU - Reny,J L, PY - 2001/10/5/pubmed PY - 2002/4/9/medline PY - 2001/10/5/entrez SP - 809 EP - 16 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 86 IS - 3 N2 - Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors involved in venous thromboembolism (VTE). The goal of this pooled analysis of 8 case-control studies, comprising a total of 2310 cases and 3204 controls, was to precisely estimate the risk of VTE in patients bearing both mutations (double heterozygotes). Odds ratios for VTE were 4.9 (95% CI; 4.1-5.9) for the factor V Leiden and 3.8 (3.0-4.9) for the factor II G20210A mutation. Fifty-one cases (2.2%) and none of the controls were double heterozygotes. The odds ratio for venous thrombosis in double heterozygotes was 20.0 (11.1-36.1). Twelve percent of patients heterozygous for factor V Leiden were also heterozygous for factor II G20210A and conversely 23% of patients heterozygous for factor II G20210A were also heterozygous for factor V Leiden. Furthermore, in this large population we analyzed the effect of oral contraceptive (OC) in women carrying one of these mutations. Odds ratio for VTE associated with OC was 2.29 (1.72-3.04). In factor V Leiden carriers using OC, the odds ratio for VTE was 10.25 (5.69-1 8.45). The odds ratio of the association of factor II mutation and OC use was 7.14 (3.39-15.04). Finally, we also confirmed that the frequency of factor V Leiden was lower in patients with pulmonary embolism than in patients with deep vein thrombosis without PE (odds ratio 0.69). Conversely, factor II G20210A mutation was equally balanced in both patient groups. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/11583312/Combined_effect_of_factor_V_Leiden_and_prothrombin_20210A_on_the_risk_of_venous_thromboembolism__pooled_analysis_of_8_case_control_studies_including_2310_cases_and_3204_controls__Study_Group_for_Pooled_Analysis_in_Venous_Thromboembolism_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11583312.ui DB - PRIME DP - Unbound Medicine ER -