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Primitive neuroectodermal tumor of the uterus. A case report.
J Reprod Med. 2001 Sep; 46(9):845-8.JR

Abstract

BACKGROUND

Primitive neuroectodermal tumors (PNETs) of the uterus are very rare. Even preoperative curettage specimen morphology does not permit establishing a proper histogenetic diagnosis.

CASE

A 16-year-old woman was admitted to the hospital because of metrorrhagia of three months' duration. The curettage specimen was interpreted as poorly differentiated sarcoma. The patient was operated on, and a total abdominal hysterectomy with bilateral salpingo-oophorectomy with omentectomy was performed. Histologically the tumor was composed of uniform, rounded, oval and sometimes spindle shaped cells with a narrow rim of eosinophilic cytoplasm. The cells were positive for neurogenic marker protein gene product, neuron-specific enolase and Ewing's sarcoma-related HBA-71. All cells were uniformly negative for Ber EP4 monoclonal antibody recognizing an epithelium-specific surface antigen. A diagnosis of PNET was rendered. The patient received combined therapy, external radiation to the pelvis and chemotherapy. Four years later she was alive, without signs of recurrent tumor.

CONCLUSION

In spite of the generally recognized aggressive behavior of PNET, it can have a long disease-free survival rate when appropriately treated.

Authors+Show Affiliations

Department of Pathology, Cancer Research Centre, Moscow, Russia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11584489

Citation

Karseladze, A I., et al. "Primitive Neuroectodermal Tumor of the Uterus. a Case Report." The Journal of Reproductive Medicine, vol. 46, no. 9, 2001, pp. 845-8.
Karseladze AI, Filipova NA, Navarro S, et al. Primitive neuroectodermal tumor of the uterus. A case report. J Reprod Med. 2001;46(9):845-8.
Karseladze, A. I., Filipova, N. A., Navarro, S., & Llombart-Bosch, A. (2001). Primitive neuroectodermal tumor of the uterus. A case report. The Journal of Reproductive Medicine, 46(9), 845-8.
Karseladze AI, et al. Primitive Neuroectodermal Tumor of the Uterus. a Case Report. J Reprod Med. 2001;46(9):845-8. PubMed PMID: 11584489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primitive neuroectodermal tumor of the uterus. A case report. AU - Karseladze,A I, AU - Filipova,N A, AU - Navarro,S, AU - Llombart-Bosch,A, PY - 2001/10/5/pubmed PY - 2002/2/8/medline PY - 2001/10/5/entrez SP - 845 EP - 8 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 46 IS - 9 N2 - BACKGROUND: Primitive neuroectodermal tumors (PNETs) of the uterus are very rare. Even preoperative curettage specimen morphology does not permit establishing a proper histogenetic diagnosis. CASE: A 16-year-old woman was admitted to the hospital because of metrorrhagia of three months' duration. The curettage specimen was interpreted as poorly differentiated sarcoma. The patient was operated on, and a total abdominal hysterectomy with bilateral salpingo-oophorectomy with omentectomy was performed. Histologically the tumor was composed of uniform, rounded, oval and sometimes spindle shaped cells with a narrow rim of eosinophilic cytoplasm. The cells were positive for neurogenic marker protein gene product, neuron-specific enolase and Ewing's sarcoma-related HBA-71. All cells were uniformly negative for Ber EP4 monoclonal antibody recognizing an epithelium-specific surface antigen. A diagnosis of PNET was rendered. The patient received combined therapy, external radiation to the pelvis and chemotherapy. Four years later she was alive, without signs of recurrent tumor. CONCLUSION: In spite of the generally recognized aggressive behavior of PNET, it can have a long disease-free survival rate when appropriately treated. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/11584489/Primitive_neuroectodermal_tumor_of_the_uterus__A_case_report_ L2 - https://medlineplus.gov/uterinecancer.html DB - PRIME DP - Unbound Medicine ER -