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Cervical primitive neuroectodermal tumor.
Gynecol Oncol. 2001 Oct; 83(1):138-42.GO

Abstract

BACKGROUND

Primitive neuroectodermal tumors (PNETs) are rare and potentially aggressive malignancies.

CASE

A 24-year-old woman in her eighth week of pregnancy presented with a cervical mass. Tissue biopsy demonstrated poorly differentiated carcinosarcoma with neuroendocrine features. Immunohistochemical studies confirmed the diagnosis of PNET. Treatment included alternating courses of cyclophosphamide, adriamycin, vincristine (CAV) and ifosfamide, etoposide (IE). A radical hysterectomy with bilateral ovarian transposition and periaortic lymphadenectomy was performed with postoperative chemotherapy and radiotherapy. The patient remains disease free 2 years from therapy.

CONCLUSION

This is a rare case of cervical PNET occurring in a pregnant patient. A review of the literature indicates that cervical PNET is distinguishable from uterine PNET. This tumor affects younger women and may have a different histogenesis. Pregnancy should not delay diagnosis of this potentially aggressive tumor.

Authors+Show Affiliations

Department of Internal Medicine, Indiana University, Indianapolis, Indiana 46202-5427, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11585426

Citation

Tsao, A S., et al. "Cervical Primitive Neuroectodermal Tumor." Gynecologic Oncology, vol. 83, no. 1, 2001, pp. 138-42.
Tsao AS, Roth LM, Sandler A, et al. Cervical primitive neuroectodermal tumor. Gynecol Oncol. 2001;83(1):138-42.
Tsao, A. S., Roth, L. M., Sandler, A., & Hurteau, J. A. (2001). Cervical primitive neuroectodermal tumor. Gynecologic Oncology, 83(1), 138-42.
Tsao AS, et al. Cervical Primitive Neuroectodermal Tumor. Gynecol Oncol. 2001;83(1):138-42. PubMed PMID: 11585426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cervical primitive neuroectodermal tumor. AU - Tsao,A S, AU - Roth,L M, AU - Sandler,A, AU - Hurteau,J A, PY - 2001/10/5/pubmed PY - 2001/10/26/medline PY - 2001/10/5/entrez SP - 138 EP - 42 JF - Gynecologic oncology JO - Gynecol Oncol VL - 83 IS - 1 N2 - BACKGROUND: Primitive neuroectodermal tumors (PNETs) are rare and potentially aggressive malignancies. CASE: A 24-year-old woman in her eighth week of pregnancy presented with a cervical mass. Tissue biopsy demonstrated poorly differentiated carcinosarcoma with neuroendocrine features. Immunohistochemical studies confirmed the diagnosis of PNET. Treatment included alternating courses of cyclophosphamide, adriamycin, vincristine (CAV) and ifosfamide, etoposide (IE). A radical hysterectomy with bilateral ovarian transposition and periaortic lymphadenectomy was performed with postoperative chemotherapy and radiotherapy. The patient remains disease free 2 years from therapy. CONCLUSION: This is a rare case of cervical PNET occurring in a pregnant patient. A review of the literature indicates that cervical PNET is distinguishable from uterine PNET. This tumor affects younger women and may have a different histogenesis. Pregnancy should not delay diagnosis of this potentially aggressive tumor. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/11585426/Cervical_primitive_neuroectodermal_tumor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(01)96339-5 DB - PRIME DP - Unbound Medicine ER -