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Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study.
Cancer Res 2001; 61(19):7136-41CR

Abstract

Folate is involved in DNA synthesis, repair, and methylation. It has been hypothesized that high intake of folate may reduce the risk of human cancers, including cancer of the breast. Using data from a population-based case-control study of breast cancer conducted in urban Shanghai during 1996-1998, we evaluated the association of dietary folate intake and breast cancer risk among 1321 cases and 1382 controls, 25-64 years of age, who never drank alcohol regularly or used vitamin supplements. Usual dietary habits were assessed with an in-person, interviewer-administered food frequency questionnaire developed and tested for use in this population. Unconditional logistic regression models were used to calculate odds ratios (ORs) and their 95% confidence intervals (95% CIs) after adjusting for potential confounding factors. Dietary folate intake was inversely associated with breast cancer risk (P for trend, 0.05) with an adjusted OR of 0.71 (95% CI, 0.56-0.92) observed among women who were in the highest quintile of intake. The inverse association was stronger after further adjusting for total fruit and vegetable and animal food intakes (OR, 0.62; 95% CI, 0.46-0.82; P for trend, 0.01). A more pronounced inverse association between folate intake and breast cancer risk (OR, 0.47; 95% CI, 0.25-0.88; P for trend, 0.01) was observed among women who consumed high levels of folate cofactors (methionine, vitamin B(12), and vitamin B(6)) than those whose intake levels of these nutrients were low. Dietary intake of methionine, vitamin B(12), and vitamin B(6) were not independently related to risk of breast cancer after adjusting for confounding factors. Thus, our study adds additional support to the protective role of dietary folate in breast carcinogenesis and suggests further that the effect of folate may be modified by dietary intake of methionine, vitamin B(12), and vitamin B(6).

Authors+Show Affiliations

Division of General Internal Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11585746

Citation

Shrubsole, M J., et al. "Dietary Folate Intake and Breast Cancer Risk: Results From the Shanghai Breast Cancer Study." Cancer Research, vol. 61, no. 19, 2001, pp. 7136-41.
Shrubsole MJ, Jin F, Dai Q, et al. Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Res. 2001;61(19):7136-41.
Shrubsole, M. J., Jin, F., Dai, Q., Shu, X. O., Potter, J. D., Hebert, J. R., ... Zheng, W. (2001). Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Research, 61(19), pp. 7136-41.
Shrubsole MJ, et al. Dietary Folate Intake and Breast Cancer Risk: Results From the Shanghai Breast Cancer Study. Cancer Res. 2001 Oct 1;61(19):7136-41. PubMed PMID: 11585746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. AU - Shrubsole,M J, AU - Jin,F, AU - Dai,Q, AU - Shu,X O, AU - Potter,J D, AU - Hebert,J R, AU - Gao,Y T, AU - Zheng,W, PY - 2001/10/5/pubmed PY - 2001/10/19/medline PY - 2001/10/5/entrez SP - 7136 EP - 41 JF - Cancer research JO - Cancer Res. VL - 61 IS - 19 N2 - Folate is involved in DNA synthesis, repair, and methylation. It has been hypothesized that high intake of folate may reduce the risk of human cancers, including cancer of the breast. Using data from a population-based case-control study of breast cancer conducted in urban Shanghai during 1996-1998, we evaluated the association of dietary folate intake and breast cancer risk among 1321 cases and 1382 controls, 25-64 years of age, who never drank alcohol regularly or used vitamin supplements. Usual dietary habits were assessed with an in-person, interviewer-administered food frequency questionnaire developed and tested for use in this population. Unconditional logistic regression models were used to calculate odds ratios (ORs) and their 95% confidence intervals (95% CIs) after adjusting for potential confounding factors. Dietary folate intake was inversely associated with breast cancer risk (P for trend, 0.05) with an adjusted OR of 0.71 (95% CI, 0.56-0.92) observed among women who were in the highest quintile of intake. The inverse association was stronger after further adjusting for total fruit and vegetable and animal food intakes (OR, 0.62; 95% CI, 0.46-0.82; P for trend, 0.01). A more pronounced inverse association between folate intake and breast cancer risk (OR, 0.47; 95% CI, 0.25-0.88; P for trend, 0.01) was observed among women who consumed high levels of folate cofactors (methionine, vitamin B(12), and vitamin B(6)) than those whose intake levels of these nutrients were low. Dietary intake of methionine, vitamin B(12), and vitamin B(6) were not independently related to risk of breast cancer after adjusting for confounding factors. Thus, our study adds additional support to the protective role of dietary folate in breast carcinogenesis and suggests further that the effect of folate may be modified by dietary intake of methionine, vitamin B(12), and vitamin B(6). SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/11585746/Dietary_folate_intake_and_breast_cancer_risk:_results_from_the_Shanghai_Breast_Cancer_Study_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11585746 DB - PRIME DP - Unbound Medicine ER -