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Nutrient intake and risk of subtypes of esophageal and gastric cancer.

Abstract

Incidence rates for adenocarcinoma of the esophagus and gastric cardia have been rising rapidly. We examined nutrient intake as a risk factor for esophageal and gastric cancers in a population-based case-control study in Connecticut, New Jersey, and western Washington state. Interviews were completed for cases with histologically confirmed esophageal adenocarcinoma (n = 282), adenocarcinoma of the gastric cardia (n = 255), esophageal squamous cell carcinoma (n = 206), and noncardia gastric adenocarcinoma (n = 352), along with population controls (n = 687). Associations between nutrient intake and risk of cancer were estimated by adjusted odds ratios (ORs), comparing the 75th versus the 25th percentile of intake. The following nutrients were significantly inversely associated with risk of all four tumor types: fiber, beta-carotene, folate, and vitamins C and B6. In contrast, dietary cholesterol, animal protein, and vitamin B12 were significantly positively associated with risk of all four tumor types. Dietary fat [OR, 2.18; 95% confidence interval (CI), 1.27-3.76] was significantly associated with risk of esophageal adenocarcinoma only. Dietary nitrite (OR, 1.65; 95% CI, 1.26-2.16) was associated with noncardia gastric cancer only. Vitamin C supplement use was associated with a significantly lower risk for noncardia gastric cancer (OR, 0.60; 95% CI, 0.41-0.88). Higher intake of nutrients found primarily in plant-based foods was associated with a reduced risk of adenocarcinomas of the esophagus and gastric cardia, whereas higher intake of nutrients found primarily in foods of animal origin was associated with an increased risk.

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  • Authors+Show Affiliations

    ,

    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut 06520-8034, USA. Susan.Mayne@Yale.Edu

    , , , , , , , , , , , ,

    Source

    MeSH

    Adenocarcinoma
    Adult
    Age Distribution
    Aged
    Carcinoma, Squamous Cell
    Case-Control Studies
    Confidence Intervals
    Connecticut
    Diet
    Esophageal Neoplasms
    Female
    Humans
    Incidence
    Male
    Middle Aged
    New Jersey
    Odds Ratio
    Population Surveillance
    Reference Values
    Risk Assessment
    Risk Factors
    Sex Distribution
    Stomach Neoplasms
    Washington

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11588131

    Citation

    Mayne, S T., et al. "Nutrient Intake and Risk of Subtypes of Esophageal and Gastric Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 10, no. 10, 2001, pp. 1055-62.
    Mayne ST, Risch HA, Dubrow R, et al. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev. 2001;10(10):1055-62.
    Mayne, S. T., Risch, H. A., Dubrow, R., Chow, W. H., Gammon, M. D., Vaughan, T. L., ... Fraumeni, J. F. (2001). Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 10(10), pp. 1055-62.
    Mayne ST, et al. Nutrient Intake and Risk of Subtypes of Esophageal and Gastric Cancer. Cancer Epidemiol Biomarkers Prev. 2001;10(10):1055-62. PubMed PMID: 11588131.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutrient intake and risk of subtypes of esophageal and gastric cancer. AU - Mayne,S T, AU - Risch,H A, AU - Dubrow,R, AU - Chow,W H, AU - Gammon,M D, AU - Vaughan,T L, AU - Farrow,D C, AU - Schoenberg,J B, AU - Stanford,J L, AU - Ahsan,H, AU - West,A B, AU - Rotterdam,H, AU - Blot,W J, AU - Fraumeni,J F,Jr PY - 2001/10/6/pubmed PY - 2002/1/5/medline PY - 2001/10/6/entrez SP - 1055 EP - 62 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 10 IS - 10 N2 - Incidence rates for adenocarcinoma of the esophagus and gastric cardia have been rising rapidly. We examined nutrient intake as a risk factor for esophageal and gastric cancers in a population-based case-control study in Connecticut, New Jersey, and western Washington state. Interviews were completed for cases with histologically confirmed esophageal adenocarcinoma (n = 282), adenocarcinoma of the gastric cardia (n = 255), esophageal squamous cell carcinoma (n = 206), and noncardia gastric adenocarcinoma (n = 352), along with population controls (n = 687). Associations between nutrient intake and risk of cancer were estimated by adjusted odds ratios (ORs), comparing the 75th versus the 25th percentile of intake. The following nutrients were significantly inversely associated with risk of all four tumor types: fiber, beta-carotene, folate, and vitamins C and B6. In contrast, dietary cholesterol, animal protein, and vitamin B12 were significantly positively associated with risk of all four tumor types. Dietary fat [OR, 2.18; 95% confidence interval (CI), 1.27-3.76] was significantly associated with risk of esophageal adenocarcinoma only. Dietary nitrite (OR, 1.65; 95% CI, 1.26-2.16) was associated with noncardia gastric cancer only. Vitamin C supplement use was associated with a significantly lower risk for noncardia gastric cancer (OR, 0.60; 95% CI, 0.41-0.88). Higher intake of nutrients found primarily in plant-based foods was associated with a reduced risk of adenocarcinomas of the esophagus and gastric cardia, whereas higher intake of nutrients found primarily in foods of animal origin was associated with an increased risk. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/11588131/Nutrient_intake_and_risk_of_subtypes_of_esophageal_and_gastric_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11588131 DB - PRIME DP - Unbound Medicine ER -