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Variant effect of first- and second-generation antihistamines as clues to their mechanism of action on the sneeze reflex in the common cold.
Clin Infect Dis 2001; 33(9):1483-8CI

Abstract

Treatment with first-generation antihistamines reduces sneezing, rhinorrhea, nasal mucus weight, and, in some instances, cough in subjects with experimental or natural colds; however, treatment with second-generation antihistamines has not been effective for these complaints in trials in subjects with natural colds. This article reports the negative results of a clinical trial with loratadine, a second-generation antihistamine, in adults in the rhinovirus challenge model. This finding in the highly controlled setting of the challenge model confirms the earlier negative studies with second-generation antihistamines in natural colds. First-generation antihistamines block both histaminic and muscarinic receptors as well as passing the blood-brain barrier. Second-generation antihistamines mainly block histaminic receptors and do not pass the blood-brain barrier. The effectiveness of first-generation antihistamines in blocking sneezing in colds may be due primarily to neuropharmacological manipulation of histaminic and muscarinic receptors in the medulla.

Authors+Show Affiliations

Aachen Medical School, Aachen, Germany.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11588693

Citation

Muether, P S., and J M. Gwaltney. "Variant Effect of First- and Second-generation Antihistamines as Clues to Their Mechanism of Action On the Sneeze Reflex in the Common Cold." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 33, no. 9, 2001, pp. 1483-8.
Muether PS, Gwaltney JM. Variant effect of first- and second-generation antihistamines as clues to their mechanism of action on the sneeze reflex in the common cold. Clin Infect Dis. 2001;33(9):1483-8.
Muether, P. S., & Gwaltney, J. M. (2001). Variant effect of first- and second-generation antihistamines as clues to their mechanism of action on the sneeze reflex in the common cold. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 33(9), pp. 1483-8.
Muether PS, Gwaltney JM. Variant Effect of First- and Second-generation Antihistamines as Clues to Their Mechanism of Action On the Sneeze Reflex in the Common Cold. Clin Infect Dis. 2001 Nov 1;33(9):1483-8. PubMed PMID: 11588693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variant effect of first- and second-generation antihistamines as clues to their mechanism of action on the sneeze reflex in the common cold. AU - Muether,P S, AU - Gwaltney,J M,Jr Y1 - 2001/10/04/ PY - 2001/01/17/received PY - 2001/04/18/revised PY - 2001/10/6/pubmed PY - 2002/1/10/medline PY - 2001/10/6/entrez SP - 1483 EP - 8 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 33 IS - 9 N2 - Treatment with first-generation antihistamines reduces sneezing, rhinorrhea, nasal mucus weight, and, in some instances, cough in subjects with experimental or natural colds; however, treatment with second-generation antihistamines has not been effective for these complaints in trials in subjects with natural colds. This article reports the negative results of a clinical trial with loratadine, a second-generation antihistamine, in adults in the rhinovirus challenge model. This finding in the highly controlled setting of the challenge model confirms the earlier negative studies with second-generation antihistamines in natural colds. First-generation antihistamines block both histaminic and muscarinic receptors as well as passing the blood-brain barrier. Second-generation antihistamines mainly block histaminic receptors and do not pass the blood-brain barrier. The effectiveness of first-generation antihistamines in blocking sneezing in colds may be due primarily to neuropharmacological manipulation of histaminic and muscarinic receptors in the medulla. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/11588693/Variant_effect_of_first__and_second_generation_antihistamines_as_clues_to_their_mechanism_of_action_on_the_sneeze_reflex_in_the_common_cold_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/322518 DB - PRIME DP - Unbound Medicine ER -