Tags

Type your tag names separated by a space and hit enter

Changes in lipoprotein(a) levels and hormonal correlations during a weight reduction program.
Nutr Metab Cardiovasc Dis. 2001 Jun; 11(3):153-7.NM

Abstract

BACKGROUND AND AIM

To examine the effects of a weight reduction program on serum lipoprotein(a) [Lp(a)] levels and investigate whether the hormonal modifications occurring during weight loss may explain the changes in Lp(a) levels.

METHODS AND RESULTS

This longitudinal clinical intervention study of a low-calorie diet involved 62 healthy obese patients (21 men aged 32 +/- 9.6 years and 41 women aged 37 +/- 14.6 years). Their anthropometric parameters (weight, height, body mass index, waist-to-hip ratio), fasting serum lipid levels, hormones (total testosterone, estradiol, total triiodothyronine, insulin), sex hormone binding globulin (SHBG) and blood sugar levels were determined at baseline and after six weeks of dietary treatment. A 7.5% loss in initial body weight was achieved and there was a statistically significant decrease in serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides (p < 0.001). No changes in Lp(a) levels were observed in the study population as a whole, but there was a 17.6% (p < 0.05) reduction in the subjects with high pre-treatment Lp(a) values (> 20 mg/dL). The decrease in Lp(a) levels closely correlated with initial Lp(a) levels (r = 0.81 p < 0.001), but did not correlate with changes in anthropometric parameters or the hormonal modifications occurring during the weight loss.

CONCLUSIONS

A low-calorie diet associated with weight loss in obese subjects may have beneficial effects on serum Lp(a) levels in patients with high pre-treatment Lp(a) concentrations. This effect seems to be independent of the hormonal changes observed during weight loss.

Authors+Show Affiliations

Kiortsis DN
Department of Endocrinology, La Pitié-Salpêtrière Hospital, Paris, France.
Tzotzas T
No affiliation info available
Giral P
No affiliation info available
Bruckert E
No affiliation info available
Beucler I
No affiliation info available
Valsamides S
No affiliation info available
Turpin G
No affiliation info available

MeSH

AdultCholesterolCholesterol, LDLDiet, ReducingEstradiolFemaleGonadal Steroid HormonesHormonesHumansInsulinLipoprotein(a)Lipoproteins, HDLMaleObesitySex Hormone-Binding GlobulinTestosteroneTriglyceridesTriiodothyronineWeight Loss

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11590990

Clinical Trial Links

A Defined, Plant-based, 4-week Dietary Intervention Reduces Lp(a) and Other Atherogenic Particles

Citation

Kiortsis, D N., et al. "Changes in Lipoprotein(a) Levels and Hormonal Correlations During a Weight Reduction Program." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 11, no. 3, 2001, pp. 153-7.
Kiortsis DN, Tzotzas T, Giral P, et al. Changes in lipoprotein(a) levels and hormonal correlations during a weight reduction program. Nutr Metab Cardiovasc Dis. 2001;11(3):153-7.
Kiortsis, D. N., Tzotzas, T., Giral, P., Bruckert, E., Beucler, I., Valsamides, S., & Turpin, G. (2001). Changes in lipoprotein(a) levels and hormonal correlations during a weight reduction program. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 11(3), 153-7.
Kiortsis DN, et al. Changes in Lipoprotein(a) Levels and Hormonal Correlations During a Weight Reduction Program. Nutr Metab Cardiovasc Dis. 2001;11(3):153-7. PubMed PMID: 11590990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in lipoprotein(a) levels and hormonal correlations during a weight reduction program. AU - Kiortsis,D N, AU - Tzotzas,T, AU - Giral,P, AU - Bruckert,E, AU - Beucler,I, AU - Valsamides,S, AU - Turpin,G, PY - 2001/10/10/pubmed PY - 2002/2/9/medline PY - 2001/10/10/entrez SP - 153 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 11 IS - 3 N2 - BACKGROUND AND AIM: To examine the effects of a weight reduction program on serum lipoprotein(a) [Lp(a)] levels and investigate whether the hormonal modifications occurring during weight loss may explain the changes in Lp(a) levels. METHODS AND RESULTS: This longitudinal clinical intervention study of a low-calorie diet involved 62 healthy obese patients (21 men aged 32 +/- 9.6 years and 41 women aged 37 +/- 14.6 years). Their anthropometric parameters (weight, height, body mass index, waist-to-hip ratio), fasting serum lipid levels, hormones (total testosterone, estradiol, total triiodothyronine, insulin), sex hormone binding globulin (SHBG) and blood sugar levels were determined at baseline and after six weeks of dietary treatment. A 7.5% loss in initial body weight was achieved and there was a statistically significant decrease in serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides (p < 0.001). No changes in Lp(a) levels were observed in the study population as a whole, but there was a 17.6% (p < 0.05) reduction in the subjects with high pre-treatment Lp(a) values (> 20 mg/dL). The decrease in Lp(a) levels closely correlated with initial Lp(a) levels (r = 0.81 p < 0.001), but did not correlate with changes in anthropometric parameters or the hormonal modifications occurring during the weight loss. CONCLUSIONS: A low-calorie diet associated with weight loss in obese subjects may have beneficial effects on serum Lp(a) levels in patients with high pre-treatment Lp(a) concentrations. This effect seems to be independent of the hormonal changes observed during weight loss. SN - 0939-4753 UR - https://www.unboundmedicine.com/medline/citation/11590990/Changes_in_lipoprotein_a__levels_and_hormonal_correlations_during_a_weight_reduction_program_ L2 - https://ClinicalTrials.gov/search/term=11590990 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -