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Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study.

Abstract

In the Netherlands Cohort Study among 120 852 subjects aged 55-69 years at baseline (1986), the association between vitamins and carotenoids intake, vitamin supplement use, and bladder cancer incidence was examined. Exposure status was measured with a food-frequency questionnaire. After 6.3 years of follow-up, data from 569 cases and 3123 subcohort members were available for case-cohort analyses. The age-, sex-, and smoking-adjusted relative risks (RRs) for retinol, vitamin E, folate, a-carotene, b-carotene, lutein and zeaxanthin, and lycopene were 1.04, 0.98, 1.03, 0.99, 1.16, 1.11, and 1.08, respectively, comparing highest to lowest quintile of intake. Only vitamin C (RR: 0.81, 95% CI: 0.61-1.07, P-trend = 0.08), and b-cryptoxanthin intake (RR: 0.74, 95% CI: 0.53-1.03, P-trend < 0.01) were inversely associated with bladder cancer risk. The association with vitamin C disappeared after adjustment for b-cryptoxanthin but not vice versa. The RRs for supplemental use of vitamin A, C or E compared to no use were around unity. We conclude that dietary or supplemental intake of vitamin A, vitamin C, vitamin E, and intake of folate, and most carotenoids are not associated with bladder cancer. In this study, only b-cryptoxanthin intake appeared to be inversely associated.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.

    ,

    Source

    British journal of cancer 85:7 2001 Sep 28 pg 977-83

    MeSH

    Aged
    Ascorbic Acid
    Carotenoids
    Cohort Studies
    Diet
    Female
    Folic Acid
    Humans
    Incidence
    Male
    Middle Aged
    Netherlands
    Risk Factors
    Urinary Bladder Neoplasms
    Vitamin A
    Vitamin E

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11592769

    Citation

    Zeegers, M P., et al. "Are Retinol, Vitamin C, Vitamin E, Folate and Carotenoids Intake Associated With Bladder Cancer Risk? Results From the Netherlands Cohort Study." British Journal of Cancer, vol. 85, no. 7, 2001, pp. 977-83.
    Zeegers MP, Goldbohm RA, van den Brandt PA. Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. Br J Cancer. 2001;85(7):977-83.
    Zeegers, M. P., Goldbohm, R. A., & van den Brandt, P. A. (2001). Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. British Journal of Cancer, 85(7), pp. 977-83.
    Zeegers MP, Goldbohm RA, van den Brandt PA. Are Retinol, Vitamin C, Vitamin E, Folate and Carotenoids Intake Associated With Bladder Cancer Risk? Results From the Netherlands Cohort Study. Br J Cancer. 2001 Sep 28;85(7):977-83. PubMed PMID: 11592769.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. AU - Zeegers,M P, AU - Goldbohm,R A, AU - van den Brandt,P A, PY - 2001/10/11/pubmed PY - 2002/1/5/medline PY - 2001/10/11/entrez SP - 977 EP - 83 JF - British journal of cancer JO - Br. J. Cancer VL - 85 IS - 7 N2 - In the Netherlands Cohort Study among 120 852 subjects aged 55-69 years at baseline (1986), the association between vitamins and carotenoids intake, vitamin supplement use, and bladder cancer incidence was examined. Exposure status was measured with a food-frequency questionnaire. After 6.3 years of follow-up, data from 569 cases and 3123 subcohort members were available for case-cohort analyses. The age-, sex-, and smoking-adjusted relative risks (RRs) for retinol, vitamin E, folate, a-carotene, b-carotene, lutein and zeaxanthin, and lycopene were 1.04, 0.98, 1.03, 0.99, 1.16, 1.11, and 1.08, respectively, comparing highest to lowest quintile of intake. Only vitamin C (RR: 0.81, 95% CI: 0.61-1.07, P-trend = 0.08), and b-cryptoxanthin intake (RR: 0.74, 95% CI: 0.53-1.03, P-trend < 0.01) were inversely associated with bladder cancer risk. The association with vitamin C disappeared after adjustment for b-cryptoxanthin but not vice versa. The RRs for supplemental use of vitamin A, C or E compared to no use were around unity. We conclude that dietary or supplemental intake of vitamin A, vitamin C, vitamin E, and intake of folate, and most carotenoids are not associated with bladder cancer. In this study, only b-cryptoxanthin intake appeared to be inversely associated. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/11592769/Are_retinol_vitamin_C_vitamin_E_folate_and_carotenoids_intake_associated_with_bladder_cancer_risk_Results_from_the_Netherlands_Cohort_Study_ L2 - http://dx.doi.org/10.1054/bjoc.2001.1968 DB - PRIME DP - Unbound Medicine ER -