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Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study.
Br J Cancer. 2001 Sep 28; 85(7):977-83.BJ

Abstract

In the Netherlands Cohort Study among 120 852 subjects aged 55-69 years at baseline (1986), the association between vitamins and carotenoids intake, vitamin supplement use, and bladder cancer incidence was examined. Exposure status was measured with a food-frequency questionnaire. After 6.3 years of follow-up, data from 569 cases and 3123 subcohort members were available for case-cohort analyses. The age-, sex-, and smoking-adjusted relative risks (RRs) for retinol, vitamin E, folate, a-carotene, b-carotene, lutein and zeaxanthin, and lycopene were 1.04, 0.98, 1.03, 0.99, 1.16, 1.11, and 1.08, respectively, comparing highest to lowest quintile of intake. Only vitamin C (RR: 0.81, 95% CI: 0.61-1.07, P-trend = 0.08), and b-cryptoxanthin intake (RR: 0.74, 95% CI: 0.53-1.03, P-trend < 0.01) were inversely associated with bladder cancer risk. The association with vitamin C disappeared after adjustment for b-cryptoxanthin but not vice versa. The RRs for supplemental use of vitamin A, C or E compared to no use were around unity. We conclude that dietary or supplemental intake of vitamin A, vitamin C, vitamin E, and intake of folate, and most carotenoids are not associated with bladder cancer. In this study, only b-cryptoxanthin intake appeared to be inversely associated.

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Authors+Show Affiliations

Zeegers MP
Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.
Goldbohm RA
No affiliation info available
van den Brandt PA
No affiliation info available

MeSH

AgedAscorbic AcidCarotenoidsCohort StudiesDietFemaleFolic AcidHumansIncidenceMaleMiddle AgedNetherlandsRisk FactorsUrinary Bladder NeoplasmsVitamin AVitamin E

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11592769

Citation

Zeegers, M P., et al. "Are Retinol, Vitamin C, Vitamin E, Folate and Carotenoids Intake Associated With Bladder Cancer Risk? Results From the Netherlands Cohort Study." British Journal of Cancer, vol. 85, no. 7, 2001, pp. 977-83.
Zeegers MP, Goldbohm RA, van den Brandt PA. Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. Br J Cancer. 2001;85(7):977-83.
Zeegers, M. P., Goldbohm, R. A., & van den Brandt, P. A. (2001). Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. British Journal of Cancer, 85(7), 977-83.
Zeegers MP, Goldbohm RA, van den Brandt PA. Are Retinol, Vitamin C, Vitamin E, Folate and Carotenoids Intake Associated With Bladder Cancer Risk? Results From the Netherlands Cohort Study. Br J Cancer. 2001 Sep 28;85(7):977-83. PubMed PMID: 11592769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. AU - Zeegers,M P, AU - Goldbohm,R A, AU - van den Brandt,P A, PY - 2001/10/11/pubmed PY - 2002/1/5/medline PY - 2001/10/11/entrez SP - 977 EP - 83 JF - British journal of cancer JO - Br J Cancer VL - 85 IS - 7 N2 - In the Netherlands Cohort Study among 120 852 subjects aged 55-69 years at baseline (1986), the association between vitamins and carotenoids intake, vitamin supplement use, and bladder cancer incidence was examined. Exposure status was measured with a food-frequency questionnaire. After 6.3 years of follow-up, data from 569 cases and 3123 subcohort members were available for case-cohort analyses. The age-, sex-, and smoking-adjusted relative risks (RRs) for retinol, vitamin E, folate, a-carotene, b-carotene, lutein and zeaxanthin, and lycopene were 1.04, 0.98, 1.03, 0.99, 1.16, 1.11, and 1.08, respectively, comparing highest to lowest quintile of intake. Only vitamin C (RR: 0.81, 95% CI: 0.61-1.07, P-trend = 0.08), and b-cryptoxanthin intake (RR: 0.74, 95% CI: 0.53-1.03, P-trend < 0.01) were inversely associated with bladder cancer risk. The association with vitamin C disappeared after adjustment for b-cryptoxanthin but not vice versa. The RRs for supplemental use of vitamin A, C or E compared to no use were around unity. We conclude that dietary or supplemental intake of vitamin A, vitamin C, vitamin E, and intake of folate, and most carotenoids are not associated with bladder cancer. In this study, only b-cryptoxanthin intake appeared to be inversely associated. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/11592769/Are_retinol_vitamin_C_vitamin_E_folate_and_carotenoids_intake_associated_with_bladder_cancer_risk_Results_from_the_Netherlands_Cohort_Study_ L2 - https://doi.org/10.1054/bjoc.2001.1968 DB - PRIME DP - Unbound Medicine ER -