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Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: role of L-propionyl carnitine administration.
Pharmacol Res. 2001 Oct; 44(4):305-9.PR

Abstract

An open study was carried out to assess whether, in patients with occlusive peripheral arterial disease (PAD), ischaemic stress induced by maximal physical exercise is associated with leukocyte activation processes, and to evaluate the effects of L-propionyl carnitine (LPC) administration on such processes. Fifteen patients with occlusive PAD (stage II-A), with a mean pain-free walking distance (PWD) of 199 +/- 70.66 m were orally treated with 2000 mg/day LPC for 2 months. Serum levels of E-selectin, P-selectin, L-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-I (VCAM-1) were measured at rest and after the performance of a treadmill walking test (treadmill speed 3.5 km h(-1), inclination 12%) in the untreated condition, and again after treatment with LPC. Significant increases of these factors were observed after maximal exercise compared with resting values. Such increase was significantly reduced after LPC treatment compared with the untreated condition. This study shows that ischaemia induced by maximal stress is associated with leukocyte activation processes, and that LPC is capable of modulating these processes. LPC, therefore, may have a protecting role during ischaemia.

Authors+Show Affiliations

Istituto di Medicina Interna A.Francaviglia, Servizio Autonomo di Angiologia Medica, Catania, Italy. signct@citiesonline.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

11592865

Citation

Signorelli, S S., et al. "Effects of Ischaemic Stress On Leukocyte Activation Processes in Patients With Chronic Peripheral Occlusive Arterial Disease: Role of L-propionyl Carnitine Administration." Pharmacological Research, vol. 44, no. 4, 2001, pp. 305-9.
Signorelli SS, Malaponte G, Di Pino L, et al. Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: role of L-propionyl carnitine administration. Pharmacol Res. 2001;44(4):305-9.
Signorelli, S. S., Malaponte, G., Di Pino, L., Digrandi, D., Pennisi, G., & Mazzarino, M. C. (2001). Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: role of L-propionyl carnitine administration. Pharmacological Research, 44(4), 305-9.
Signorelli SS, et al. Effects of Ischaemic Stress On Leukocyte Activation Processes in Patients With Chronic Peripheral Occlusive Arterial Disease: Role of L-propionyl Carnitine Administration. Pharmacol Res. 2001;44(4):305-9. PubMed PMID: 11592865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: role of L-propionyl carnitine administration. AU - Signorelli,S S, AU - Malaponte,G, AU - Di Pino,L, AU - Digrandi,D, AU - Pennisi,G, AU - Mazzarino,M C, PY - 2001/10/11/pubmed PY - 2002/1/23/medline PY - 2001/10/11/entrez SP - 305 EP - 9 JF - Pharmacological research JO - Pharmacol. Res. VL - 44 IS - 4 N2 - An open study was carried out to assess whether, in patients with occlusive peripheral arterial disease (PAD), ischaemic stress induced by maximal physical exercise is associated with leukocyte activation processes, and to evaluate the effects of L-propionyl carnitine (LPC) administration on such processes. Fifteen patients with occlusive PAD (stage II-A), with a mean pain-free walking distance (PWD) of 199 +/- 70.66 m were orally treated with 2000 mg/day LPC for 2 months. Serum levels of E-selectin, P-selectin, L-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-I (VCAM-1) were measured at rest and after the performance of a treadmill walking test (treadmill speed 3.5 km h(-1), inclination 12%) in the untreated condition, and again after treatment with LPC. Significant increases of these factors were observed after maximal exercise compared with resting values. Such increase was significantly reduced after LPC treatment compared with the untreated condition. This study shows that ischaemia induced by maximal stress is associated with leukocyte activation processes, and that LPC is capable of modulating these processes. LPC, therefore, may have a protecting role during ischaemia. SN - 1043-6618 UR - https://www.unboundmedicine.com/medline/citation/11592865/Effects_of_ischaemic_stress_on_leukocyte_activation_processes_in_patients_with_chronic_peripheral_occlusive_arterial_disease:_role_of_L_propionyl_carnitine_administration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043661801908631 DB - PRIME DP - Unbound Medicine ER -