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Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans.
Eur J Clin Nutr 2001; 55(10):881-6EJ

Abstract

OBJECTIVE

To assess the effects in humans of regular ingestion of black tea on haemostasis-related variables and cell adhesion molecules.

DESIGN

Twenty-two subjects were recruited from the general population to a randomised-controlled crossover study. Subjects stopped drinking tea, apart from that provided, for the duration of the study. During a 4-week baseline period all subjects drank 5 cups/day (250 ml) of hot water. The effects of 5 cups/day of black tea for 4 weeks were then compared with hot water. Platelet aggregation in response to three doses of collagen and ADP, plasma concentrations of coagulation and fibrinolytic factors (fibrinogen, factor VII, tPA, PAI-1) and plasma concentrations of cell adhesion molecules (soluble P-selectin, E-selectin, ICAM-1, VCAM-1) were assessed twice, one week apart, at the end of each period. Twenty-four hour urinary concentration of 4-O-methylgallic acid (4OMGA), assessed once at the end of each period, was used as a marker of black tea polyphenol intake.

RESULTS

The 24 h urinary excretion of 4OMGA was increased during regular ingestion of black tea in comparison to hot water (P<0.0001). Black tea resulted in lower soluble P-selectin (P=0.01) in comparison to hot water, but did not influence other adhesion molecules. Soluble P-selectin was significantly correlated with mean collagen-stimulated platelet aggregation at baseline (r=0.61, P=0.003), and during regular ingestion of hot water (r=0.70, P<0.0001) and black tea (r=0.51, P=0.01). However, platelet aggregation was not different between the black tea and hot water periods for collagen- or ADP-stimulated aggregation at any dose. Coagulation and fibrinolytic factors were also not different between periods.

CONCLUSIONS

The effect of black tea on soluble P-selectin provides a potential mechanism for cardiovascular benefits of regular ingestion of tea.

SPONSORSHIP

This study was supported by grants from the Tea Trade Health Research Association and the National Heart Foundation of Australia.

Authors+Show Affiliations

University of Western Australia Department of Medicine and HeartSearch, Royal Perth Hospital, Perth, Western Australia, Australia. jonathan@cyllene.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11593350

Citation

Hodgson, J M., et al. "Effects of Regular Ingestion of Black Tea On Haemostasis and Cell Adhesion Molecules in Humans." European Journal of Clinical Nutrition, vol. 55, no. 10, 2001, pp. 881-6.
Hodgson JM, Puddey IB, Mori TA, et al. Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans. Eur J Clin Nutr. 2001;55(10):881-6.
Hodgson, J. M., Puddey, I. B., Mori, T. A., Burke, V., Baker, R. I., & Beilin, L. J. (2001). Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans. European Journal of Clinical Nutrition, 55(10), pp. 881-6.
Hodgson JM, et al. Effects of Regular Ingestion of Black Tea On Haemostasis and Cell Adhesion Molecules in Humans. Eur J Clin Nutr. 2001;55(10):881-6. PubMed PMID: 11593350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans. AU - Hodgson,J M, AU - Puddey,I B, AU - Mori,T A, AU - Burke,V, AU - Baker,R I, AU - Beilin,L J, PY - 2000/10/30/received PY - 2001/02/20/revised PY - 2001/03/29/accepted PY - 2001/10/11/pubmed PY - 2001/11/3/medline PY - 2001/10/11/entrez SP - 881 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 55 IS - 10 N2 - OBJECTIVE: To assess the effects in humans of regular ingestion of black tea on haemostasis-related variables and cell adhesion molecules. DESIGN: Twenty-two subjects were recruited from the general population to a randomised-controlled crossover study. Subjects stopped drinking tea, apart from that provided, for the duration of the study. During a 4-week baseline period all subjects drank 5 cups/day (250 ml) of hot water. The effects of 5 cups/day of black tea for 4 weeks were then compared with hot water. Platelet aggregation in response to three doses of collagen and ADP, plasma concentrations of coagulation and fibrinolytic factors (fibrinogen, factor VII, tPA, PAI-1) and plasma concentrations of cell adhesion molecules (soluble P-selectin, E-selectin, ICAM-1, VCAM-1) were assessed twice, one week apart, at the end of each period. Twenty-four hour urinary concentration of 4-O-methylgallic acid (4OMGA), assessed once at the end of each period, was used as a marker of black tea polyphenol intake. RESULTS: The 24 h urinary excretion of 4OMGA was increased during regular ingestion of black tea in comparison to hot water (P<0.0001). Black tea resulted in lower soluble P-selectin (P=0.01) in comparison to hot water, but did not influence other adhesion molecules. Soluble P-selectin was significantly correlated with mean collagen-stimulated platelet aggregation at baseline (r=0.61, P=0.003), and during regular ingestion of hot water (r=0.70, P<0.0001) and black tea (r=0.51, P=0.01). However, platelet aggregation was not different between the black tea and hot water periods for collagen- or ADP-stimulated aggregation at any dose. Coagulation and fibrinolytic factors were also not different between periods. CONCLUSIONS: The effect of black tea on soluble P-selectin provides a potential mechanism for cardiovascular benefits of regular ingestion of tea. SPONSORSHIP: This study was supported by grants from the Tea Trade Health Research Association and the National Heart Foundation of Australia. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/11593350/Effects_of_regular_ingestion_of_black_tea_on_haemostasis_and_cell_adhesion_molecules_in_humans_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601231 DB - PRIME DP - Unbound Medicine ER -