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Clinical correlates of action tremor in Parkinson disease.
Arch Neurol. 2001 Oct; 58(10):1630-4.AN

Abstract

BACKGROUND

Action tremor is often noted in patients with Parkinson disease (PD), yet the clinical correlates of this type of tremor have been the focus of few studies. It is not clear whether this action tremor is a manifestation of the underlying basal ganglia disease.

OBJECTIVE

To determine whether the severity of action tremor in PD is associated with age, age at disease onset, disease duration, levodopa dose, severity of rest tremor, or other motor (ie, bradykinesia, rigidity) and nonmotor manifestations of PD.

METHODS

Patients with PD (N = 197) were ascertained as part of a familial aggregation study. All patients underwent a neurological examination. Rest tremor was rated with the Unified Parkinson Disease Rating Scale; and action tremor, with the Washington Heights-Inwood Genetic Study of Essential Tremor Rating Scale.

RESULTS

Action tremor was present in 184 (93.4%) of 197 patients. Four patients (2%) met criteria for definite essential tremor. The action tremor score was not associated with age, age at onset, or disease duration. The action tremor score was associated with the rest tremor score (r = 0.37; P<.001), and more strongly with the ipsilateral than contralateral rest tremor score. The association between the action tremor score and the rest tremor score was diminished but still significant (r = 0.21, P<.02) even when we excluded these 63 patients with re-emergent tremor. Neither the action nor the rest tremor score was associated with the bradykinesia or rigidity scores, Hoehn and Yahr scale score, or modified Mini-Mental State Examination score.

CONCLUSIONS

Action tremor was associated with rest tremor in PD, suggesting that, at least in part, action tremor is a manifestation of the underlying basal ganglia disease. Neither tremor was associated with other motor and nonmotor manifestations of PD. This in turn suggests that tremor in PD may represent an underlying pathophysiological process different from these other manifestations.

Authors+Show Affiliations

Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. EDL2@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11594921

Citation

Louis, E D., et al. "Clinical Correlates of Action Tremor in Parkinson Disease." Archives of Neurology, vol. 58, no. 10, 2001, pp. 1630-4.
Louis ED, Levy G, Côte LJ, et al. Clinical correlates of action tremor in Parkinson disease. Arch Neurol. 2001;58(10):1630-4.
Louis, E. D., Levy, G., Côte, L. J., Mejia, H., Fahn, S., & Marder, K. (2001). Clinical correlates of action tremor in Parkinson disease. Archives of Neurology, 58(10), 1630-4.
Louis ED, et al. Clinical Correlates of Action Tremor in Parkinson Disease. Arch Neurol. 2001;58(10):1630-4. PubMed PMID: 11594921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical correlates of action tremor in Parkinson disease. AU - Louis,E D, AU - Levy,G, AU - Côte,L J, AU - Mejia,H, AU - Fahn,S, AU - Marder,K, PY - 2001/10/27/pubmed PY - 2001/11/3/medline PY - 2001/10/27/entrez SP - 1630 EP - 4 JF - Archives of neurology JO - Arch Neurol VL - 58 IS - 10 N2 - BACKGROUND: Action tremor is often noted in patients with Parkinson disease (PD), yet the clinical correlates of this type of tremor have been the focus of few studies. It is not clear whether this action tremor is a manifestation of the underlying basal ganglia disease. OBJECTIVE: To determine whether the severity of action tremor in PD is associated with age, age at disease onset, disease duration, levodopa dose, severity of rest tremor, or other motor (ie, bradykinesia, rigidity) and nonmotor manifestations of PD. METHODS: Patients with PD (N = 197) were ascertained as part of a familial aggregation study. All patients underwent a neurological examination. Rest tremor was rated with the Unified Parkinson Disease Rating Scale; and action tremor, with the Washington Heights-Inwood Genetic Study of Essential Tremor Rating Scale. RESULTS: Action tremor was present in 184 (93.4%) of 197 patients. Four patients (2%) met criteria for definite essential tremor. The action tremor score was not associated with age, age at onset, or disease duration. The action tremor score was associated with the rest tremor score (r = 0.37; P<.001), and more strongly with the ipsilateral than contralateral rest tremor score. The association between the action tremor score and the rest tremor score was diminished but still significant (r = 0.21, P<.02) even when we excluded these 63 patients with re-emergent tremor. Neither the action nor the rest tremor score was associated with the bradykinesia or rigidity scores, Hoehn and Yahr scale score, or modified Mini-Mental State Examination score. CONCLUSIONS: Action tremor was associated with rest tremor in PD, suggesting that, at least in part, action tremor is a manifestation of the underlying basal ganglia disease. Neither tremor was associated with other motor and nonmotor manifestations of PD. This in turn suggests that tremor in PD may represent an underlying pathophysiological process different from these other manifestations. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/11594921/Clinical_correlates_of_action_tremor_in_Parkinson_disease_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/58/pg/1630 DB - PRIME DP - Unbound Medicine ER -