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Eradication of Helicobacter pylori has no effect on gastric acidity in duodenal ulcer patients--evaluation of 24-h pH monitoring.

Abstract

It is accepted that eradication of Helicobacter pylori leads to healing of chronic active gastritis facilitates ulcer healing and prevents ulcer recurrence in duodenal ulcer (DU) patients. However, it is not entirely known whether the eradication of the bacteria normalizes gastric acid secretion and abolishes dyspeptic symptoms after ulcer healing. This study was aimed to evaluate the intragastric acidity and dyspeptic complaints before, and 3 months after, eradication in 18 endoscopically proven H. pylori positive DU patients. Gastric pH was measured by 24-h continuous intraluminal recording, serum gastrin measurements and Congo-red tests were also performed. Dyspeptic complaints and antacid consumptions were recorded in diary cards, antisecretory therapy was not allowed after the cessation of eradication therapy. Endoscopy, H. pylori status and Congo-red tests were controlled at the 6th and 12th week, while pH measurements and serum gastrin tests were performed at inclusion and 3 months later. Three patients dropped out and in 14 out of the remaining subjects healing of DUs and successful eradication was achieved by the 6th and 12th week controls. The 24-h median pH and the percentage of 24-h pH readings under pH 3 were not changing significantly by the 3-month controls (from 1.9+/-0.5 to 1.8+/-0.4 and from 52.6+/-5.5% to 58.6+/-5%, respectively). Similarly, no significant changes were observed in serum gastrin levels and dyspeptic symptom scores (from 72+/-7 pg/ml to 56.7+/-8 pg/ml and from 2.69+/-0.4 to 1.26+/-0.3, respectively). The antacid consumption was almost stable when compared with the pre- and post-eradication periods. It was concluded that despite successful H. pylori eradication and healing of DU, intragastric acidity does not change significantly at least 3 months after the therapy. The persisting dyspeptic symptoms and the need for antacid consumption suggest that some healed ulcer patients require antisecretory therapy in the post-eradication period.

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  • Authors+Show Affiliations

    ,

    First Department of Medicine and Pathology, Petz Aladár County and Teaching Hospital, 9024 Gyor, Vasvári Pál 2, Hungary. dr_racz_istvan@arrabonet.gyor.hu

    , , ,

    Source

    MeSH

    Adult
    Aged
    Antacids
    Anti-Bacterial Agents
    Circadian Rhythm
    Duodenal Ulcer
    Dyspepsia
    Female
    Gastric Acid
    Helicobacter Infections
    Helicobacter pylori
    Humans
    Hydrogen-Ion Concentration
    Male
    Middle Aged
    Monitoring, Physiologic
    Time Factors

    Pub Type(s)

    Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    11595477

    Citation

    Rácz, I, et al. "Eradication of Helicobacter Pylori Has No Effect On Gastric Acidity in Duodenal Ulcer Patients--evaluation of 24-h pH Monitoring." Journal of Physiology, Paris, vol. 95, no. 1-6, 2001, pp. 469-75.
    Rácz I, Szabó A, Csöndes M, et al. Eradication of Helicobacter pylori has no effect on gastric acidity in duodenal ulcer patients--evaluation of 24-h pH monitoring. J Physiol Paris. 2001;95(1-6):469-75.
    Rácz, I., Szabó, A., Csöndes, M., Pécsi, G., & Goda, M. (2001). Eradication of Helicobacter pylori has no effect on gastric acidity in duodenal ulcer patients--evaluation of 24-h pH monitoring. Journal of Physiology, Paris, 95(1-6), pp. 469-75.
    Rácz I, et al. Eradication of Helicobacter Pylori Has No Effect On Gastric Acidity in Duodenal Ulcer Patients--evaluation of 24-h pH Monitoring. J Physiol Paris. 2001;95(1-6):469-75. PubMed PMID: 11595477.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Eradication of Helicobacter pylori has no effect on gastric acidity in duodenal ulcer patients--evaluation of 24-h pH monitoring. AU - Rácz,I, AU - Szabó,A, AU - Csöndes,M, AU - Pécsi,G, AU - Goda,M, PY - 2001/10/12/pubmed PY - 2002/2/20/medline PY - 2001/10/12/entrez SP - 469 EP - 75 JF - Journal of physiology, Paris JO - J. Physiol. Paris VL - 95 IS - 1-6 N2 - It is accepted that eradication of Helicobacter pylori leads to healing of chronic active gastritis facilitates ulcer healing and prevents ulcer recurrence in duodenal ulcer (DU) patients. However, it is not entirely known whether the eradication of the bacteria normalizes gastric acid secretion and abolishes dyspeptic symptoms after ulcer healing. This study was aimed to evaluate the intragastric acidity and dyspeptic complaints before, and 3 months after, eradication in 18 endoscopically proven H. pylori positive DU patients. Gastric pH was measured by 24-h continuous intraluminal recording, serum gastrin measurements and Congo-red tests were also performed. Dyspeptic complaints and antacid consumptions were recorded in diary cards, antisecretory therapy was not allowed after the cessation of eradication therapy. Endoscopy, H. pylori status and Congo-red tests were controlled at the 6th and 12th week, while pH measurements and serum gastrin tests were performed at inclusion and 3 months later. Three patients dropped out and in 14 out of the remaining subjects healing of DUs and successful eradication was achieved by the 6th and 12th week controls. The 24-h median pH and the percentage of 24-h pH readings under pH 3 were not changing significantly by the 3-month controls (from 1.9+/-0.5 to 1.8+/-0.4 and from 52.6+/-5.5% to 58.6+/-5%, respectively). Similarly, no significant changes were observed in serum gastrin levels and dyspeptic symptom scores (from 72+/-7 pg/ml to 56.7+/-8 pg/ml and from 2.69+/-0.4 to 1.26+/-0.3, respectively). The antacid consumption was almost stable when compared with the pre- and post-eradication periods. It was concluded that despite successful H. pylori eradication and healing of DU, intragastric acidity does not change significantly at least 3 months after the therapy. The persisting dyspeptic symptoms and the need for antacid consumption suggest that some healed ulcer patients require antisecretory therapy in the post-eradication period. SN - 0928-4257 UR - https://www.unboundmedicine.com/medline/citation/11595477/Eradication_of_Helicobacter_pylori_has_no_effect_on_gastric_acidity_in_duodenal_ulcer_patients__evaluation_of_24_h_pH_monitoring_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-4257(01)00065-1 DB - PRIME DP - Unbound Medicine ER -