Tags

Type your tag names separated by a space and hit enter

[The anti-anaphylactic action of potassium channel openers and its mechanism].
Yao Xue Xue Bao. 1997 Dec; 32(12):888-92.YX

Abstract

The anti-anaphylactic action of potassium channel openers was studied and reported in this paper. Minoxidil(Min) was shown to inhibit passive cutaneous anaphylaxis in rats. Diazoxide (Dia) and Min were found to inhibit antigen-induced guinea-pig ileum smooth muscle contraction in vitro. Min was shown to antagonize 5-HT-induced capillary permeability in rat skin. Dia was demonstrated to inhibit histamine release from rat peritoneal mast cells induced by A23187 and compound 48/80, but it failed to antagonize guinea-pig ileum smooth muscle contraction induced by histamine in vitro. These results provide evidence that potassium channel openers may be a new group of inhibitors of histamine release and indicate that the mechanism of its anti-anaphylactic action may be related to its potassium channel opening effect. As a result of this effect, Ca2+ influx to the mast cells decreases and Ca2+ release from calcium storage was inhibited, thus inhibiting histamine release.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Zhejiang Medical University, Hangzhou 310031.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11596183

Citation

Wang, P, et al. "[The Anti-anaphylactic Action of Potassium Channel Openers and Its Mechanism]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 32, no. 12, 1997, pp. 888-92.
Wang P, Xu JH, Wei EQ. [The anti-anaphylactic action of potassium channel openers and its mechanism]. Yao Xue Xue Bao. 1997;32(12):888-92.
Wang, P., Xu, J. H., & Wei, E. Q. (1997). [The anti-anaphylactic action of potassium channel openers and its mechanism]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 32(12), 888-92.
Wang P, Xu JH, Wei EQ. [The Anti-anaphylactic Action of Potassium Channel Openers and Its Mechanism]. Yao Xue Xue Bao. 1997;32(12):888-92. PubMed PMID: 11596183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The anti-anaphylactic action of potassium channel openers and its mechanism]. AU - Wang,P, AU - Xu,J H, AU - Wei,E Q, PY - 2001/10/13/pubmed PY - 2001/11/3/medline PY - 2001/10/13/entrez SP - 888 EP - 92 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 32 IS - 12 N2 - The anti-anaphylactic action of potassium channel openers was studied and reported in this paper. Minoxidil(Min) was shown to inhibit passive cutaneous anaphylaxis in rats. Diazoxide (Dia) and Min were found to inhibit antigen-induced guinea-pig ileum smooth muscle contraction in vitro. Min was shown to antagonize 5-HT-induced capillary permeability in rat skin. Dia was demonstrated to inhibit histamine release from rat peritoneal mast cells induced by A23187 and compound 48/80, but it failed to antagonize guinea-pig ileum smooth muscle contraction induced by histamine in vitro. These results provide evidence that potassium channel openers may be a new group of inhibitors of histamine release and indicate that the mechanism of its anti-anaphylactic action may be related to its potassium channel opening effect. As a result of this effect, Ca2+ influx to the mast cells decreases and Ca2+ release from calcium storage was inhibited, thus inhibiting histamine release. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/11596183/[The_anti_anaphylactic_action_of_potassium_channel_openers_and_its_mechanism]_ L2 - https://medlineplus.gov/anaphylaxis.html DB - PRIME DP - Unbound Medicine ER -