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Coeliac disease, anaemia and pregnancy.
Clin Lab 2001; 47(9-10):467-9CL

Abstract

We have investigated the prevalence of positive serology for coeliac disease in pregnant women, using the IgA anti-endomysium antibody test. Five of 216 pregnant women with a haemoglobin less than 11 g/dl were positive, compared to 0/350 with haemoglobin > or = 11 g/dl. Four of these five had low plasma ferritin levels, indicative of iron deficiency anaemia; the fifth was borderline normal. We found no association between positive coeliac disease serology and folate deficiency. None of thirty mothers of children born with neural tube defects were IgA anti-endomysium antibody positive. This study has identified a very high prevalence of occult coeliac disease in pregnancy and a strong association with anaemia. We advise that in cases with a haemoglobin of less than 11 g/dl in pregnancy, coeliac disease should be excluded.

Authors+Show Affiliations

Department of Gastroenterology, Bury General Hospital, Lancashire, United Kingdom.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11596908

Citation

Haslam, N, et al. "Coeliac Disease, Anaemia and Pregnancy." Clinical Laboratory, vol. 47, no. 9-10, 2001, pp. 467-9.
Haslam N, Lock RJ, Unsworth DJ. Coeliac disease, anaemia and pregnancy. Clin Lab. 2001;47(9-10):467-9.
Haslam, N., Lock, R. J., & Unsworth, D. J. (2001). Coeliac disease, anaemia and pregnancy. Clinical Laboratory, 47(9-10), pp. 467-9.
Haslam N, Lock RJ, Unsworth DJ. Coeliac Disease, Anaemia and Pregnancy. Clin Lab. 2001;47(9-10):467-9. PubMed PMID: 11596908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coeliac disease, anaemia and pregnancy. AU - Haslam,N, AU - Lock,R J, AU - Unsworth,D J, PY - 2001/10/13/pubmed PY - 2002/10/9/medline PY - 2001/10/13/entrez SP - 467 EP - 9 JF - Clinical laboratory JO - Clin. Lab. VL - 47 IS - 9-10 N2 - We have investigated the prevalence of positive serology for coeliac disease in pregnant women, using the IgA anti-endomysium antibody test. Five of 216 pregnant women with a haemoglobin less than 11 g/dl were positive, compared to 0/350 with haemoglobin > or = 11 g/dl. Four of these five had low plasma ferritin levels, indicative of iron deficiency anaemia; the fifth was borderline normal. We found no association between positive coeliac disease serology and folate deficiency. None of thirty mothers of children born with neural tube defects were IgA anti-endomysium antibody positive. This study has identified a very high prevalence of occult coeliac disease in pregnancy and a strong association with anaemia. We advise that in cases with a haemoglobin of less than 11 g/dl in pregnancy, coeliac disease should be excluded. SN - 1433-6510 UR - https://www.unboundmedicine.com/medline/citation/11596908/Coeliac_disease_anaemia_and_pregnancy_ L2 - http://www.diseaseinfosearch.org/result/5922 DB - PRIME DP - Unbound Medicine ER -