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A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease.
J Pediatr 2001; 139(4):516-21JPed

Abstract

OBJECTIVE

Because osteopenia is a frequent complication of celiac disease, we evaluated the impact of a long-term gluten-free diet (GFD), initiated during childhood, on bone density. study design: Patients with celiac disease (n = 19; mean age, 14.2 +/- 2.6 years) were studied after 4.3 +/- 0.6 years of GFD. Bone density had been measured at diagnosis and after 1 year of GFD. We also studied 211 healthy children as a control group. Bone mineral density was measured by dual-energy x-ray absorptiometry. Intact parathyroid hormone (PTH) and bone-specific alkaline phosphatase (BALP) levels were measured in serum, and N-terminal telopeptide of type I collagen (NTx) was measured in urine.

RESULTS

Although at diagnosis bone mineral content, bone area, and bone mineral density were significantly lower than in control subjects, the 3 measurements were normal after GFD. None of the patients on a GFD showed elevated values of PTH. Patients on a GFD had BALP (110.2 +/- 67.2 U/L) and NTx levels (261.9 +/- 187.8 nmol bone collagen equivalents/mmol creatinine) that were significantly higher than those of control subjects. The levels of BALP and NTx were significantly higher in patients with good compliance with the GFD, compared with patients with poorer compliance.

CONCLUSIONS

This study shows that bone mineral content, bone area, and bone mineral density improve significantly with a GFD.

Authors+Show Affiliations

Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, University of Milan, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

11598597

Citation

Mora, S, et al. "A Prospective, Longitudinal Study of the Long-term Effect of Treatment On Bone Density in Children With Celiac Disease." The Journal of Pediatrics, vol. 139, no. 4, 2001, pp. 516-21.
Mora S, Barera G, Beccio S, et al. A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease. J Pediatr. 2001;139(4):516-21.
Mora, S., Barera, G., Beccio, S., Menni, L., Proverbio, M. C., Bianchi, C., & Chiumello, G. (2001). A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease. The Journal of Pediatrics, 139(4), pp. 516-21.
Mora S, et al. A Prospective, Longitudinal Study of the Long-term Effect of Treatment On Bone Density in Children With Celiac Disease. J Pediatr. 2001;139(4):516-21. PubMed PMID: 11598597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease. AU - Mora,S, AU - Barera,G, AU - Beccio,S, AU - Menni,L, AU - Proverbio,M C, AU - Bianchi,C, AU - Chiumello,G, PY - 2001/10/13/pubmed PY - 2002/1/5/medline PY - 2001/10/13/entrez SP - 516 EP - 21 JF - The Journal of pediatrics JO - J. Pediatr. VL - 139 IS - 4 N2 - OBJECTIVE: Because osteopenia is a frequent complication of celiac disease, we evaluated the impact of a long-term gluten-free diet (GFD), initiated during childhood, on bone density. study design: Patients with celiac disease (n = 19; mean age, 14.2 +/- 2.6 years) were studied after 4.3 +/- 0.6 years of GFD. Bone density had been measured at diagnosis and after 1 year of GFD. We also studied 211 healthy children as a control group. Bone mineral density was measured by dual-energy x-ray absorptiometry. Intact parathyroid hormone (PTH) and bone-specific alkaline phosphatase (BALP) levels were measured in serum, and N-terminal telopeptide of type I collagen (NTx) was measured in urine. RESULTS: Although at diagnosis bone mineral content, bone area, and bone mineral density were significantly lower than in control subjects, the 3 measurements were normal after GFD. None of the patients on a GFD showed elevated values of PTH. Patients on a GFD had BALP (110.2 +/- 67.2 U/L) and NTx levels (261.9 +/- 187.8 nmol bone collagen equivalents/mmol creatinine) that were significantly higher than those of control subjects. The levels of BALP and NTx were significantly higher in patients with good compliance with the GFD, compared with patients with poorer compliance. CONCLUSIONS: This study shows that bone mineral content, bone area, and bone mineral density improve significantly with a GFD. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/11598597/A_prospective_longitudinal_study_of_the_long_term_effect_of_treatment_on_bone_density_in_children_with_celiac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(01)38415-9 DB - PRIME DP - Unbound Medicine ER -