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Tissue-specific cadmium accumulation, metallothionein induction, and tissue zinc and copper levels during chronic sublethal cadmium exposure in juvenile rainbow trout.
Arch Environ Contam Toxicol. 2001 Nov; 41(4):468-74.AE

Abstract

Juvenile rainbow trout, on 3% of body weight daily ration, were exposed to 0 (control) or 3 microg/L Cd (as Cd(NO3)2*4H2O) in moderately hard (140 mg/L as CaCO3), alkaline (95 mg/L as CaCO3, pH 8.0) water for 30 days. Particular attention focused on Cd burden in tissues (gills, liver, kidney, and whole body) and induction of metallothionein (MT) in gills, liver, and kidney during chronic Cd exposure. Mortality in Cd-exposed fish was minimal (approximately 10%), and no growth effects occurred over the 30-day exposure. Cd accumulated in a time-dependent fashion to 9 times (gills), 3 times (liver), 20 times (kidney), 2 times (carcass), and 2 times (whole body) control levels by 30 days; absolute concentrations were in the order kidney > gill > liver > whole body > carcass. Tissue (gills, liver, and kidney) Zn and Cu burdens were not altered by chronic exposure to 3 microg/L Cd. MT concentrations in all tissues increased over the 30 days of Cd exposure, but the increases were much less than those of Cd on a molar binding site basis. Absolute MT concentrations were in the order liver > kidney > gill, but relative increases were greatest in kidney (fourfold), followed by gills (twofold) and liver (1.3-fold). MT levels were sufficient to bind all Cd in gill, liver, and kidney under control conditions, and after chronic Cd exposure remained sufficient in liver and kidney, but not in gills. Total metal levels (Cd + Zn + Cu) greatly exceeded MT binding capacity in all tissues under all conditions.

Authors+Show Affiliations

Hollis L
Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada. lmhollis@ucalgary.ca
Hogstrand C
No affiliation info available
Wood CM
No affiliation info available

MeSH

AnimalsCadmiumCopperDose-Response Relationship, DrugEnzyme InductionGillsKidneyLiverMetallothioneinOncorhynchus mykissRandom AllocationTissue DistributionWater Pollutants, ChemicalZinc

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11598784

Citation

Hollis, L, et al. "Tissue-specific Cadmium Accumulation, Metallothionein Induction, and Tissue Zinc and Copper Levels During Chronic Sublethal Cadmium Exposure in Juvenile Rainbow Trout." Archives of Environmental Contamination and Toxicology, vol. 41, no. 4, 2001, pp. 468-74.
Hollis L, Hogstrand C, Wood CM. Tissue-specific cadmium accumulation, metallothionein induction, and tissue zinc and copper levels during chronic sublethal cadmium exposure in juvenile rainbow trout. Arch Environ Contam Toxicol. 2001;41(4):468-74.
Hollis, L., Hogstrand, C., & Wood, C. M. (2001). Tissue-specific cadmium accumulation, metallothionein induction, and tissue zinc and copper levels during chronic sublethal cadmium exposure in juvenile rainbow trout. Archives of Environmental Contamination and Toxicology, 41(4), 468-74.
Hollis L, Hogstrand C, Wood CM. Tissue-specific Cadmium Accumulation, Metallothionein Induction, and Tissue Zinc and Copper Levels During Chronic Sublethal Cadmium Exposure in Juvenile Rainbow Trout. Arch Environ Contam Toxicol. 2001;41(4):468-74. PubMed PMID: 11598784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue-specific cadmium accumulation, metallothionein induction, and tissue zinc and copper levels during chronic sublethal cadmium exposure in juvenile rainbow trout. AU - Hollis,L, AU - Hogstrand,C, AU - Wood,C M, PY - 2001/02/20/received PY - 2001/05/20/accepted PY - 2001/10/13/pubmed PY - 2002/1/5/medline PY - 2001/10/13/entrez SP - 468 EP - 74 JF - Archives of environmental contamination and toxicology JO - Arch Environ Contam Toxicol VL - 41 IS - 4 N2 - Juvenile rainbow trout, on 3% of body weight daily ration, were exposed to 0 (control) or 3 microg/L Cd (as Cd(NO3)2*4H2O) in moderately hard (140 mg/L as CaCO3), alkaline (95 mg/L as CaCO3, pH 8.0) water for 30 days. Particular attention focused on Cd burden in tissues (gills, liver, kidney, and whole body) and induction of metallothionein (MT) in gills, liver, and kidney during chronic Cd exposure. Mortality in Cd-exposed fish was minimal (approximately 10%), and no growth effects occurred over the 30-day exposure. Cd accumulated in a time-dependent fashion to 9 times (gills), 3 times (liver), 20 times (kidney), 2 times (carcass), and 2 times (whole body) control levels by 30 days; absolute concentrations were in the order kidney > gill > liver > whole body > carcass. Tissue (gills, liver, and kidney) Zn and Cu burdens were not altered by chronic exposure to 3 microg/L Cd. MT concentrations in all tissues increased over the 30 days of Cd exposure, but the increases were much less than those of Cd on a molar binding site basis. Absolute MT concentrations were in the order liver > kidney > gill, but relative increases were greatest in kidney (fourfold), followed by gills (twofold) and liver (1.3-fold). MT levels were sufficient to bind all Cd in gill, liver, and kidney under control conditions, and after chronic Cd exposure remained sufficient in liver and kidney, but not in gills. Total metal levels (Cd + Zn + Cu) greatly exceeded MT binding capacity in all tissues under all conditions. SN - 0090-4341 UR - https://www.unboundmedicine.com/medline/citation/11598784/Tissue_specific_cadmium_accumulation_metallothionein_induction_and_tissue_zinc_and_copper_levels_during_chronic_sublethal_cadmium_exposure_in_juvenile_rainbow_trout_ L2 - https://dx.doi.org/10.1007/s002440010273 DB - PRIME DP - Unbound Medicine ER -