Tags

Type your tag names separated by a space and hit enter

In vitro antimicrobial activities of bakuchiol against oral microorganisms.
Antimicrob Agents Chemother 2001; 45(11):3009-13AA

Abstract

Bakuchiol was isolated from the seeds of Psoralea corylifolia, a tree native to China with various uses in traditional medicine, followed by extraction with ether and column chromatography combined with silica gel and octyldecyl silane. In this study, the antimicrobial activities of bakuchiol against some oral microorganisms were evaluated in vitro. The cell growth of Streptococcus mutans was inhibited in a bakuchiol concentration-dependent manner, and growth of S. mutans was completely prevented by 20 microg of bakuchiol per ml. The bactericidal effect of bakuchiol on S. mutans was dependent on temperature and stable under the following conditions: sucrose, 0 to 10% (wt/vol); pH, 3.0 to 7.0; organic acids (3% [wt/vol] citric and malic acids). Bakuchiol showed bactericidal effects against all bacteria tested, including S. mutans, Streptococcus sanguis, Streptococcus salivarius, Streptococcus sobrinus, Enterococcus faecalis, Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Actinomyces viscosus, and Porphyromonas gingivalis, with MICs ranging from 1 to 4 microg/ml and the sterilizing concentration for 15 min ranging from 5 to 20 microg/ml. Furthermore, bakuchiol was also effective against adherent cells of S. mutans in water-insoluble glucan in the presence of sucrose and inhibited the reduction of pH in the broth. Thus, bakuchiol would be a useful compound for development of antibacterial agents against oral pathogens and has great potential for use in food additives and mouthwash for preventing and treating dental caries.

Authors+Show Affiliations

Research Laboratory of Higashimaru Shoyu Co. Ltd., 100-3, Tominaga, Tatsuno, Hyogo 679-4193, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11600349

Citation

Katsura, H, et al. "In Vitro Antimicrobial Activities of Bakuchiol Against Oral Microorganisms." Antimicrobial Agents and Chemotherapy, vol. 45, no. 11, 2001, pp. 3009-13.
Katsura H, Tsukiyama RI, Suzuki A, et al. In vitro antimicrobial activities of bakuchiol against oral microorganisms. Antimicrob Agents Chemother. 2001;45(11):3009-13.
Katsura, H., Tsukiyama, R. I., Suzuki, A., & Kobayashi, M. (2001). In vitro antimicrobial activities of bakuchiol against oral microorganisms. Antimicrobial Agents and Chemotherapy, 45(11), pp. 3009-13.
Katsura H, et al. In Vitro Antimicrobial Activities of Bakuchiol Against Oral Microorganisms. Antimicrob Agents Chemother. 2001;45(11):3009-13. PubMed PMID: 11600349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antimicrobial activities of bakuchiol against oral microorganisms. AU - Katsura,H, AU - Tsukiyama,R I, AU - Suzuki,A, AU - Kobayashi,M, PY - 2001/10/16/pubmed PY - 2002/1/24/medline PY - 2001/10/16/entrez SP - 3009 EP - 13 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 45 IS - 11 N2 - Bakuchiol was isolated from the seeds of Psoralea corylifolia, a tree native to China with various uses in traditional medicine, followed by extraction with ether and column chromatography combined with silica gel and octyldecyl silane. In this study, the antimicrobial activities of bakuchiol against some oral microorganisms were evaluated in vitro. The cell growth of Streptococcus mutans was inhibited in a bakuchiol concentration-dependent manner, and growth of S. mutans was completely prevented by 20 microg of bakuchiol per ml. The bactericidal effect of bakuchiol on S. mutans was dependent on temperature and stable under the following conditions: sucrose, 0 to 10% (wt/vol); pH, 3.0 to 7.0; organic acids (3% [wt/vol] citric and malic acids). Bakuchiol showed bactericidal effects against all bacteria tested, including S. mutans, Streptococcus sanguis, Streptococcus salivarius, Streptococcus sobrinus, Enterococcus faecalis, Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Actinomyces viscosus, and Porphyromonas gingivalis, with MICs ranging from 1 to 4 microg/ml and the sterilizing concentration for 15 min ranging from 5 to 20 microg/ml. Furthermore, bakuchiol was also effective against adherent cells of S. mutans in water-insoluble glucan in the presence of sucrose and inhibited the reduction of pH in the broth. Thus, bakuchiol would be a useful compound for development of antibacterial agents against oral pathogens and has great potential for use in food additives and mouthwash for preventing and treating dental caries. SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/11600349/In_vitro_antimicrobial_activities_of_bakuchiol_against_oral_microorganisms_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=11600349 DB - PRIME DP - Unbound Medicine ER -