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Relationship between remodeling and function of left ventricle and angiotensin II AT1 receptor expression after myocardial infarction in rats.
Chin Med J (Engl). 1999 Jul; 112(7):593-6.CM

Abstract

OBJECTIVE

To determine the relationship between remodeling and dysfunction of left ventricle (LV) and the expression of the angiotensin II AT1 receptor mRNA after myocardial infarction (MI) in rats.

METHODS

Nine MI rats (Group A) and 8 sham-operated rats (Group B) were studied by both Doppler echocardiography and Dot blot using Digoxingenin-labelled cDNA probes.

RESULTS

Compared with Group B, Group A showed the increase in LV internal diastolic diameter (0.87 +/- 0.06 mm vs 0.66 +/- 0.03 mm, respectively, P < 0.01) and volume (0.73 +/- 0.09 ml vs 0.51 +/- 0.05 ml, P < 0.01). In addition, thinning of anterior wall, thickening of posterior wall, increasing of peak early filling velocity (peak E), decreasing of late filling velocity (peak A) and increasing of the E/A were demonstrated in MI rats 7 weeks after MI. The levels of the cardiac angiotensin II AT1 receptor mRNA in Group A were higher than those of Group B (2.2-fold).

CONCLUSIONS

Seven weeks after MI in rats, character of LV remodeling and dysfunction were developed and the expression of cardiac angiotensin II AT1 receptor mRNA was increased.

Authors+Show Affiliations

Jiangmen Central Hospital, Jiangmen 529071, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11601250

Citation

Zhang, G, et al. "Relationship Between Remodeling and Function of Left Ventricle and Angiotensin II AT1 Receptor Expression After Myocardial Infarction in Rats." Chinese Medical Journal, vol. 112, no. 7, 1999, pp. 593-6.
Zhang G, Yang Y, Pu S, et al. Relationship between remodeling and function of left ventricle and angiotensin II AT1 receptor expression after myocardial infarction in rats. Chin Med J (Engl). 1999;112(7):593-6.
Zhang, G., Yang, Y., Pu, S., Shen, X., Peng, T., & Chen, H. (1999). Relationship between remodeling and function of left ventricle and angiotensin II AT1 receptor expression after myocardial infarction in rats. Chinese Medical Journal, 112(7), 593-6.
Zhang G, et al. Relationship Between Remodeling and Function of Left Ventricle and Angiotensin II AT1 Receptor Expression After Myocardial Infarction in Rats. Chin Med J (Engl). 1999;112(7):593-6. PubMed PMID: 11601250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between remodeling and function of left ventricle and angiotensin II AT1 receptor expression after myocardial infarction in rats. AU - Zhang,G, AU - Yang,Y, AU - Pu,S, AU - Shen,X, AU - Peng,T, AU - Chen,H, PY - 2001/10/17/pubmed PY - 2002/1/5/medline PY - 2001/10/17/entrez SP - 593 EP - 6 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 112 IS - 7 N2 - OBJECTIVE: To determine the relationship between remodeling and dysfunction of left ventricle (LV) and the expression of the angiotensin II AT1 receptor mRNA after myocardial infarction (MI) in rats. METHODS: Nine MI rats (Group A) and 8 sham-operated rats (Group B) were studied by both Doppler echocardiography and Dot blot using Digoxingenin-labelled cDNA probes. RESULTS: Compared with Group B, Group A showed the increase in LV internal diastolic diameter (0.87 +/- 0.06 mm vs 0.66 +/- 0.03 mm, respectively, P < 0.01) and volume (0.73 +/- 0.09 ml vs 0.51 +/- 0.05 ml, P < 0.01). In addition, thinning of anterior wall, thickening of posterior wall, increasing of peak early filling velocity (peak E), decreasing of late filling velocity (peak A) and increasing of the E/A were demonstrated in MI rats 7 weeks after MI. The levels of the cardiac angiotensin II AT1 receptor mRNA in Group A were higher than those of Group B (2.2-fold). CONCLUSIONS: Seven weeks after MI in rats, character of LV remodeling and dysfunction were developed and the expression of cardiac angiotensin II AT1 receptor mRNA was increased. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11601250/Relationship_between_remodeling_and_function_of_left_ventricle_and_angiotensin_II_AT1_receptor_expression_after_myocardial_infarction_in_rats_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -