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Subacute sclerosing panencephalitis in the hamster. Ultrastructure of the acute disease in newborns and weanlings.
Lab Invest. 1975 Aug; 33(2):108-16.LI

Abstract

Acute subacute sclerosing panencephalitis has been investigated in both newborn and weanling hamsters intracerebrally inoculated with a human subacute sclerosing panencephalitis isolate (HBS) adapted to grow in hamster central nervous system (CNS) tissue. Newborn animals developed a disease which was fatal in approximately 1 week whereas most weanlings showed signs of an acute disease after day 8, from which a significant number recovered. Ultrastructurally, the human subacute sclerosing panencephalitis isolate (HBS) replicated rapidly in the CNS of newborn hamsters in the absence of an immune response. Giant cells developed from neurons and some demyelination was evident, most probably due to oligodendrocytic damage. Virus replication involved the proliferation of both typical measles virions and morphologically defective particles. Intracytoplasmic viral nucleocapsids were seen, but none were found within nuclei during the acute disease in newborns. Weanling hamsters developed a demonstrable immune response approximately 6 days after inoculation. Virions were seen and the majority appeared morphologically defective, lacking the associated nucleocapsids beneath the viral envelope. Abundant intranuclear, as well as intracytoplasmic, viral inclusions were seen. The results are of significance in the examination of myxoviruses (a group frequently linked to a number of chronic diseases of the CNS), in terms of viral replication in the CNS, in the response of different CNS cell types to infection, and in the influence of age and immune status upon the course of CNS disease.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1160338

Citation

Raine, C S., et al. "Subacute Sclerosing Panencephalitis in the Hamster. Ultrastructure of the Acute Disease in Newborns and Weanlings." Laboratory Investigation; a Journal of Technical Methods and Pathology, vol. 33, no. 2, 1975, pp. 108-16.
Raine CS, Byington DP, Johnson KP. Subacute sclerosing panencephalitis in the hamster. Ultrastructure of the acute disease in newborns and weanlings. Lab Invest. 1975;33(2):108-16.
Raine, C. S., Byington, D. P., & Johnson, K. P. (1975). Subacute sclerosing panencephalitis in the hamster. Ultrastructure of the acute disease in newborns and weanlings. Laboratory Investigation; a Journal of Technical Methods and Pathology, 33(2), 108-16.
Raine CS, Byington DP, Johnson KP. Subacute Sclerosing Panencephalitis in the Hamster. Ultrastructure of the Acute Disease in Newborns and Weanlings. Lab Invest. 1975;33(2):108-16. PubMed PMID: 1160338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subacute sclerosing panencephalitis in the hamster. Ultrastructure of the acute disease in newborns and weanlings. AU - Raine,C S, AU - Byington,D P, AU - Johnson,K P, PY - 1975/8/1/pubmed PY - 1975/8/1/medline PY - 1975/8/1/entrez SP - 108 EP - 16 JF - Laboratory investigation; a journal of technical methods and pathology JO - Lab. Invest. VL - 33 IS - 2 N2 - Acute subacute sclerosing panencephalitis has been investigated in both newborn and weanling hamsters intracerebrally inoculated with a human subacute sclerosing panencephalitis isolate (HBS) adapted to grow in hamster central nervous system (CNS) tissue. Newborn animals developed a disease which was fatal in approximately 1 week whereas most weanlings showed signs of an acute disease after day 8, from which a significant number recovered. Ultrastructurally, the human subacute sclerosing panencephalitis isolate (HBS) replicated rapidly in the CNS of newborn hamsters in the absence of an immune response. Giant cells developed from neurons and some demyelination was evident, most probably due to oligodendrocytic damage. Virus replication involved the proliferation of both typical measles virions and morphologically defective particles. Intracytoplasmic viral nucleocapsids were seen, but none were found within nuclei during the acute disease in newborns. Weanling hamsters developed a demonstrable immune response approximately 6 days after inoculation. Virions were seen and the majority appeared morphologically defective, lacking the associated nucleocapsids beneath the viral envelope. Abundant intranuclear, as well as intracytoplasmic, viral inclusions were seen. The results are of significance in the examination of myxoviruses (a group frequently linked to a number of chronic diseases of the CNS), in terms of viral replication in the CNS, in the response of different CNS cell types to infection, and in the influence of age and immune status upon the course of CNS disease. SN - 0023-6837 UR - https://www.unboundmedicine.com/medline/citation/1160338/Subacute_sclerosing_panencephalitis_in_the_hamster__Ultrastructure_of_the_acute_disease_in_newborns_and_weanlings_ DB - PRIME DP - Unbound Medicine ER -