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In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride.
Int J Pharm. 2001 Oct 23; 229(1-2):29-36.IJ

Abstract

Thermoreversible gels formed in situ by aqueous solutions of an enzyme-degraded xyloglucan polysaccharide were evaluated as sustained release vehicles for the ocular delivery of pilocarpine hydrochloride. In vitro release of pilocarpine from gels formed by warming xyloglucan sols (1.0, 1.5 and 2.0% w/w) to 34 degrees C followed root-time kinetics over a period of 6 h. The miotic responses in rabbit following administration of xyloglucan sols were compared with those from in situ gelling Pluronic F127 sols and from an aqueous buffer solution containing the same drug concentration. Sustained release of pilocarpine was observed with all gels, the duration of miotic response increasing with increase of xyloglucan concentration. The degree of enhancement of miotic response following sustained release of pilocarpine from the 1.5% w/w xyloglucan gel was similar to that from a 25% w/w Pluronic F127 gel.

Authors+Show Affiliations

Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Ishikari-Tohbetsu, 061-0293, Hokkaido, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11604255

Citation

Miyazaki, S, et al. "In Situ Gelling Xyloglucan Formulations for Sustained Release Ocular Delivery of Pilocarpine Hydrochloride." International Journal of Pharmaceutics, vol. 229, no. 1-2, 2001, pp. 29-36.
Miyazaki S, Suzuki S, Kawasaki N, et al. In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride. Int J Pharm. 2001;229(1-2):29-36.
Miyazaki, S., Suzuki, S., Kawasaki, N., Endo, K., Takahashi, A., & Attwood, D. (2001). In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride. International Journal of Pharmaceutics, 229(1-2), 29-36.
Miyazaki S, et al. In Situ Gelling Xyloglucan Formulations for Sustained Release Ocular Delivery of Pilocarpine Hydrochloride. Int J Pharm. 2001 Oct 23;229(1-2):29-36. PubMed PMID: 11604255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride. AU - Miyazaki,S, AU - Suzuki,S, AU - Kawasaki,N, AU - Endo,K, AU - Takahashi,A, AU - Attwood,D, PY - 2001/10/18/pubmed PY - 2002/1/5/medline PY - 2001/10/18/entrez SP - 29 EP - 36 JF - International journal of pharmaceutics JO - Int J Pharm VL - 229 IS - 1-2 N2 - Thermoreversible gels formed in situ by aqueous solutions of an enzyme-degraded xyloglucan polysaccharide were evaluated as sustained release vehicles for the ocular delivery of pilocarpine hydrochloride. In vitro release of pilocarpine from gels formed by warming xyloglucan sols (1.0, 1.5 and 2.0% w/w) to 34 degrees C followed root-time kinetics over a period of 6 h. The miotic responses in rabbit following administration of xyloglucan sols were compared with those from in situ gelling Pluronic F127 sols and from an aqueous buffer solution containing the same drug concentration. Sustained release of pilocarpine was observed with all gels, the duration of miotic response increasing with increase of xyloglucan concentration. The degree of enhancement of miotic response following sustained release of pilocarpine from the 1.5% w/w xyloglucan gel was similar to that from a 25% w/w Pluronic F127 gel. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/11604255/In_situ_gelling_xyloglucan_formulations_for_sustained_release_ocular_delivery_of_pilocarpine_hydrochloride_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378517301008250 DB - PRIME DP - Unbound Medicine ER -