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A low dose alcohol drug discrimination in social drinkers: relationship with subjective effects.
Psychopharmacology (Berl). 2001 Oct; 157(4):411-20.P

Abstract

RATIONALE

Although well characterised in animals, relatively little is known about alcohol discriminative stimulus effects in humans.

OBJECTIVE

The study was carried out to investigate the correspondence of subjective effects and the discriminative response during the acquisition of a low dose alcohol discrimination in humans.

METHODS

Healthy volunteers completed an Alcohol Use Questionnaire and were then trained to discriminate a dose of 0.2 g/kg alcohol from placebo using a money reinforced technique. Subjects sampled drinks during training, but also completed rating scales measuring Taste, Like/Dislike and Subjective Effects for each drink.

RESULTS

Thirty-two subjects learned the discrimination (discriminators; Ds). In these subjects, differences between placebo scores and alcohol scores for Lightheadedness, Relaxed, Arousal and Fatigue were greater following acquisition of the discrimination, compared with differences at the start of training. Differences in other measures remained consistent. Twenty-six of the volunteers failed to learn the discrimination (non-discriminators; NDs). These subjects reported drinking approximately twice as much alcohol during the preceding 6 months, as the Ds (4.35+/-0.53 g/kg per week versus 2.08+/-0.19 g/kg per week, respectively, P<0.001). There were no alcohol specific differences in ratings for Lightheadedness, Relaxed, Arousal or Fatigue between the Ds and the NDs. However, Dislike scores did differentiate between the Ds and the NDs in that the NDs had reduced ratings for the alcohol drink only compared with the Ds (P<0.02).

CONCLUSIONS

These results support the suggestion from animal studies, that the alcohol stimulus is a compound, and characterise the subjective effects which contribute to a low dose cue in humans. In addition, the data suggest that previous drinking experience may selectively alter aversive responses to alcohol and that this, in addition to differences in general arousal levels, may have affected subjects' ability to learn the discrimination.

Authors+Show Affiliations

Department of Experimental Psychology, School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK. jackson@biols.susx.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11605101

Citation

Jackson, A, et al. "A Low Dose Alcohol Drug Discrimination in Social Drinkers: Relationship With Subjective Effects." Psychopharmacology, vol. 157, no. 4, 2001, pp. 411-20.
Jackson A, Stephens DN, Duka T. A low dose alcohol drug discrimination in social drinkers: relationship with subjective effects. Psychopharmacology (Berl). 2001;157(4):411-20.
Jackson, A., Stephens, D. N., & Duka, T. (2001). A low dose alcohol drug discrimination in social drinkers: relationship with subjective effects. Psychopharmacology, 157(4), 411-20.
Jackson A, Stephens DN, Duka T. A Low Dose Alcohol Drug Discrimination in Social Drinkers: Relationship With Subjective Effects. Psychopharmacology (Berl). 2001;157(4):411-20. PubMed PMID: 11605101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A low dose alcohol drug discrimination in social drinkers: relationship with subjective effects. AU - Jackson,A, AU - Stephens,D N, AU - Duka,T, PY - 2001/01/22/received PY - 2001/04/03/accepted PY - 2001/10/18/pubmed PY - 2002/1/5/medline PY - 2001/10/18/entrez SP - 411 EP - 20 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 157 IS - 4 N2 - RATIONALE: Although well characterised in animals, relatively little is known about alcohol discriminative stimulus effects in humans. OBJECTIVE: The study was carried out to investigate the correspondence of subjective effects and the discriminative response during the acquisition of a low dose alcohol discrimination in humans. METHODS: Healthy volunteers completed an Alcohol Use Questionnaire and were then trained to discriminate a dose of 0.2 g/kg alcohol from placebo using a money reinforced technique. Subjects sampled drinks during training, but also completed rating scales measuring Taste, Like/Dislike and Subjective Effects for each drink. RESULTS: Thirty-two subjects learned the discrimination (discriminators; Ds). In these subjects, differences between placebo scores and alcohol scores for Lightheadedness, Relaxed, Arousal and Fatigue were greater following acquisition of the discrimination, compared with differences at the start of training. Differences in other measures remained consistent. Twenty-six of the volunteers failed to learn the discrimination (non-discriminators; NDs). These subjects reported drinking approximately twice as much alcohol during the preceding 6 months, as the Ds (4.35+/-0.53 g/kg per week versus 2.08+/-0.19 g/kg per week, respectively, P<0.001). There were no alcohol specific differences in ratings for Lightheadedness, Relaxed, Arousal or Fatigue between the Ds and the NDs. However, Dislike scores did differentiate between the Ds and the NDs in that the NDs had reduced ratings for the alcohol drink only compared with the Ds (P<0.02). CONCLUSIONS: These results support the suggestion from animal studies, that the alcohol stimulus is a compound, and characterise the subjective effects which contribute to a low dose cue in humans. In addition, the data suggest that previous drinking experience may selectively alter aversive responses to alcohol and that this, in addition to differences in general arousal levels, may have affected subjects' ability to learn the discrimination. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/11605101/A_low_dose_alcohol_drug_discrimination_in_social_drinkers:_relationship_with_subjective_effects_ L2 - https://dx.doi.org/10.1007/s002130100817 DB - PRIME DP - Unbound Medicine ER -