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Pathogens in the middle ear effusion of children with persistent otitis media: implications of drug resistance and complications.
J Microbiol Immunol Infect. 2001 Sep; 34(3):190-4.JM

Abstract

Acute otitis media (AOM) is the most common disease for which pediatricians prescribe antimicrobial agents. Middle ear fluid were collected from 243 children with AOM that failed to respond to a previous course of antimicrobial therapy and who had then received myringotomy from September 1997 through August 1999. Bacterial cultures were done and antimicrobial susceptibilities were analyzed. Streptococcus pneumoniae (21.8%) was the most common causative organism, followed by Haemophilus influenzae (10.2%), Staphylococcus aureus (7%), and Pseudomonas aeruginosa (1.8%), while Moraxella catarrhalis (0.7%) and group A beta-hemolytic streptococcus (0.2%) were rarely isolated. In patients whose condition failed to improve after a course of antibiotic treatment, drug resistance became a serious problem. Fourteen percent of the patients in this series had complications, which included recurrent AOM, persistent middle ear effusion necessitating ventilation tube insertion, hearing impairment, mastoiditis, meningitis, chronic otitis media, brain abscess, and sepsis. Possible risk factors such as young age, male sex, underlying diseases, and a culture of S. pneumoniae or H. influenzae were not significantly associated with an increased incidence of complications. More stringent diagnosis and the correct choice of antibiotic treatment combined with the introduction of potential virus and bacterial vaccines are promising ways to reduce the morbidity of AOM in children.

Authors+Show Affiliations

Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11605810

Citation

Li, W C., et al. "Pathogens in the Middle Ear Effusion of Children With Persistent Otitis Media: Implications of Drug Resistance and Complications." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 34, no. 3, 2001, pp. 190-4.
Li WC, Chiu NC, Hsu CH, et al. Pathogens in the middle ear effusion of children with persistent otitis media: implications of drug resistance and complications. J Microbiol Immunol Infect. 2001;34(3):190-4.
Li, W. C., Chiu, N. C., Hsu, C. H., Lee, K. S., Hwang, H. K., & Huang, F. Y. (2001). Pathogens in the middle ear effusion of children with persistent otitis media: implications of drug resistance and complications. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 34(3), 190-4.
Li WC, et al. Pathogens in the Middle Ear Effusion of Children With Persistent Otitis Media: Implications of Drug Resistance and Complications. J Microbiol Immunol Infect. 2001;34(3):190-4. PubMed PMID: 11605810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogens in the middle ear effusion of children with persistent otitis media: implications of drug resistance and complications. AU - Li,W C, AU - Chiu,N C, AU - Hsu,C H, AU - Lee,K S, AU - Hwang,H K, AU - Huang,F Y, PY - 2001/10/19/pubmed PY - 2002/4/24/medline PY - 2001/10/19/entrez SP - 190 EP - 4 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 34 IS - 3 N2 - Acute otitis media (AOM) is the most common disease for which pediatricians prescribe antimicrobial agents. Middle ear fluid were collected from 243 children with AOM that failed to respond to a previous course of antimicrobial therapy and who had then received myringotomy from September 1997 through August 1999. Bacterial cultures were done and antimicrobial susceptibilities were analyzed. Streptococcus pneumoniae (21.8%) was the most common causative organism, followed by Haemophilus influenzae (10.2%), Staphylococcus aureus (7%), and Pseudomonas aeruginosa (1.8%), while Moraxella catarrhalis (0.7%) and group A beta-hemolytic streptococcus (0.2%) were rarely isolated. In patients whose condition failed to improve after a course of antibiotic treatment, drug resistance became a serious problem. Fourteen percent of the patients in this series had complications, which included recurrent AOM, persistent middle ear effusion necessitating ventilation tube insertion, hearing impairment, mastoiditis, meningitis, chronic otitis media, brain abscess, and sepsis. Possible risk factors such as young age, male sex, underlying diseases, and a culture of S. pneumoniae or H. influenzae were not significantly associated with an increased incidence of complications. More stringent diagnosis and the correct choice of antibiotic treatment combined with the introduction of potential virus and bacterial vaccines are promising ways to reduce the morbidity of AOM in children. SN - 1684-1182 UR - https://www.unboundmedicine.com/medline/citation/11605810/Pathogens_in_the_middle_ear_effusion_of_children_with_persistent_otitis_media:_implications_of_drug_resistance_and_complications_ L2 - https://medlineplus.gov/antibioticresistance.html DB - PRIME DP - Unbound Medicine ER -