Marihuana metabolites in urine of man. V. Characterization and separation of polar metabolites of delta-9-tetrahydrocannabinol.Res Commun Chem Pathol Pharmacol. 1975 Feb; 10(2):215-9.RC
Extraction of human urine with ether at pH 12 and thin-layer chromatography using two solvent systems permitted separation of several polar metabolites of delta-9-tetrahydrocannabinol (THC), not previously isolated by these techniques. These metabolites appeared as conjugates and are probably dihydroxy alcohols.