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Laboratory studies of a lymphocytic choriomeningitis virus outbreak in man and laboratory animals.
Am J Epidemiol. 1975 Sep; 102(3):233-40.AJ

Abstract

Investigation of an outbreak of prolonged febrile illness in medical center personnel at the University of Rochester School of Medicine and Dentistry revealed lymphocytic choriomeningitis (LCM) virus to be the causative agent. Syrian or golden hamsters (Mesocricetus auratus) were found to be the only animals involved in maintaining the virus and were the source of human infections. Isolations of LCM virus were made from autopsy specimens of 13 of 46 (28%) golden hamsters. Virus isolations were made from 22 of 28 (79%) frozen specimens of 11 tumor lines transplanted repeatedly in golden hamster cheek pouches. No virus isolations were made from 86 autopsied laboratory mice, laboratory rats, Chinese hamsters (Cricetulus griseus), or laboratory rabbits or from 10 tumor cell lines transplanted in laboratory mice. Complement-fixation testing of 301 animal sera from the vivarium also revealed involvement primarily of golden hamsters. The probable source of virus introduction into the Rochester facilities was found to be two LCM-contaminated tumor lines sent from a biological supplier to Rochester in 1969.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1163529

Citation

Bowen, G S., et al. "Laboratory Studies of a Lymphocytic Choriomeningitis Virus Outbreak in Man and Laboratory Animals." American Journal of Epidemiology, vol. 102, no. 3, 1975, pp. 233-40.
Bowen GS, Calisher CH, Winkler WG, et al. Laboratory studies of a lymphocytic choriomeningitis virus outbreak in man and laboratory animals. Am J Epidemiol. 1975;102(3):233-40.
Bowen, G. S., Calisher, C. H., Winkler, W. G., Kraus, A. L., Fowler, E. H., Garman, R. H., Fraser, D. W., & Hinman, A. R. (1975). Laboratory studies of a lymphocytic choriomeningitis virus outbreak in man and laboratory animals. American Journal of Epidemiology, 102(3), 233-40.
Bowen GS, et al. Laboratory Studies of a Lymphocytic Choriomeningitis Virus Outbreak in Man and Laboratory Animals. Am J Epidemiol. 1975;102(3):233-40. PubMed PMID: 1163529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laboratory studies of a lymphocytic choriomeningitis virus outbreak in man and laboratory animals. AU - Bowen,G S, AU - Calisher,C H, AU - Winkler,W G, AU - Kraus,A L, AU - Fowler,E H, AU - Garman,R H, AU - Fraser,D W, AU - Hinman,A R, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 233 EP - 40 JF - American journal of epidemiology JO - Am J Epidemiol VL - 102 IS - 3 N2 - Investigation of an outbreak of prolonged febrile illness in medical center personnel at the University of Rochester School of Medicine and Dentistry revealed lymphocytic choriomeningitis (LCM) virus to be the causative agent. Syrian or golden hamsters (Mesocricetus auratus) were found to be the only animals involved in maintaining the virus and were the source of human infections. Isolations of LCM virus were made from autopsy specimens of 13 of 46 (28%) golden hamsters. Virus isolations were made from 22 of 28 (79%) frozen specimens of 11 tumor lines transplanted repeatedly in golden hamster cheek pouches. No virus isolations were made from 86 autopsied laboratory mice, laboratory rats, Chinese hamsters (Cricetulus griseus), or laboratory rabbits or from 10 tumor cell lines transplanted in laboratory mice. Complement-fixation testing of 301 animal sera from the vivarium also revealed involvement primarily of golden hamsters. The probable source of virus introduction into the Rochester facilities was found to be two LCM-contaminated tumor lines sent from a biological supplier to Rochester in 1969. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/1163529/Laboratory_studies_of_a_lymphocytic_choriomeningitis_virus_outbreak_in_man_and_laboratory_animals_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a112152 DB - PRIME DP - Unbound Medicine ER -