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The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes.
Eur J Clin Nutr 2001; 55(11):951-8EJ

Abstract

OBJECTIVE

To determine the effects of meals rich in thermally stressed safflower (TSAF) and olive (TSOL) oils on postprandial serum paraoxonase (PON1) arylesterase activity and low density lipoprotein (LDL) oxidation in patients with type 2 diabetes.

DESIGN

A randomised cross-over study.

SETTING

Diabetes clinic and general practice.

SUBJECTS

Fourteen patients (six men and eight women) with type 2 diabetes, aged 48-67 y, glycated haemoglobin <10% and fasting blood glucose <11 mmol/l were recruited.

INTERVENTIONS

Patients received a milkshake rich in TSAF or TSOL and at least a week later they received the alternate milkshake. These fats contained high levels of lipid oxidation and degradation products. Blood samples were taken fasted and 4 h after consumption of the milkshake.

MAIN OUTCOME MEASURES

Serum PON1 activity and lag time in LDL oxidation.

RESULTS

After the meal rich in TSOL, serum PON1 activity increased significantly in women (12 (2.22) micromol/ml/min, mean (95% confidence interval), P=0.03) and not in men (0 (-4.4) micromol/ml/min) during the postprandial period. The increase in PON1 activity after the TSOL meal was significantly (P=0.03) greater in women compared with men. In women, the increase in serum PON1 activity after the TSOL meal was significantly different (13 (1.25) micromol/ml/min, P=0.04) compared with the corresponding change (-1 micromol/ml/min) after the TSAF meal. The lag time in LDL oxidation and indices of oxidative stress and antioxidant capacity did not vary significantly during the meals.

CONCLUSIONS

Meals rich in TSOL may increase postprandial serum PON1 activity in middle-aged and older diabetic women. This change is potentially anti-atherogenic and may favour the use of olive oil over polyunsaturated fats in the diet of patients with type 2 diabetes.

SPONSORSHIP

The study was supported by a grant from the National Heart Foundation of New Zealand.

Authors+Show Affiliations

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11641743

Citation

Wallace, A J., et al. "The Effect of Meals Rich in Thermally Stressed Olive and Safflower Oils On Postprandial Serum Paraoxonase Activity in Patients With Diabetes." European Journal of Clinical Nutrition, vol. 55, no. 11, 2001, pp. 951-8.
Wallace AJ, Sutherland WH, Mann JI, et al. The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes. Eur J Clin Nutr. 2001;55(11):951-8.
Wallace, A. J., Sutherland, W. H., Mann, J. I., & Williams, S. M. (2001). The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes. European Journal of Clinical Nutrition, 55(11), pp. 951-8.
Wallace AJ, et al. The Effect of Meals Rich in Thermally Stressed Olive and Safflower Oils On Postprandial Serum Paraoxonase Activity in Patients With Diabetes. Eur J Clin Nutr. 2001;55(11):951-8. PubMed PMID: 11641743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes. AU - Wallace,A J, AU - Sutherland,W H, AU - Mann,J I, AU - Williams,S M, PY - 2000/10/24/received PY - 2001/04/03/revised PY - 2001/04/08/accepted PY - 2001/10/20/pubmed PY - 2002/1/5/medline PY - 2001/10/20/entrez SP - 951 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 55 IS - 11 N2 - OBJECTIVE: To determine the effects of meals rich in thermally stressed safflower (TSAF) and olive (TSOL) oils on postprandial serum paraoxonase (PON1) arylesterase activity and low density lipoprotein (LDL) oxidation in patients with type 2 diabetes. DESIGN: A randomised cross-over study. SETTING: Diabetes clinic and general practice. SUBJECTS: Fourteen patients (six men and eight women) with type 2 diabetes, aged 48-67 y, glycated haemoglobin <10% and fasting blood glucose <11 mmol/l were recruited. INTERVENTIONS: Patients received a milkshake rich in TSAF or TSOL and at least a week later they received the alternate milkshake. These fats contained high levels of lipid oxidation and degradation products. Blood samples were taken fasted and 4 h after consumption of the milkshake. MAIN OUTCOME MEASURES: Serum PON1 activity and lag time in LDL oxidation. RESULTS: After the meal rich in TSOL, serum PON1 activity increased significantly in women (12 (2.22) micromol/ml/min, mean (95% confidence interval), P=0.03) and not in men (0 (-4.4) micromol/ml/min) during the postprandial period. The increase in PON1 activity after the TSOL meal was significantly (P=0.03) greater in women compared with men. In women, the increase in serum PON1 activity after the TSOL meal was significantly different (13 (1.25) micromol/ml/min, P=0.04) compared with the corresponding change (-1 micromol/ml/min) after the TSAF meal. The lag time in LDL oxidation and indices of oxidative stress and antioxidant capacity did not vary significantly during the meals. CONCLUSIONS: Meals rich in TSOL may increase postprandial serum PON1 activity in middle-aged and older diabetic women. This change is potentially anti-atherogenic and may favour the use of olive oil over polyunsaturated fats in the diet of patients with type 2 diabetes. SPONSORSHIP: The study was supported by a grant from the National Heart Foundation of New Zealand. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/11641743/The_effect_of_meals_rich_in_thermally_stressed_olive_and_safflower_oils_on_postprandial_serum_paraoxonase_activity_in_patients_with_diabetes_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601250 DB - PRIME DP - Unbound Medicine ER -