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Prospective study on milk products, calcium and cancers of the colon and rectum.

Abstract

OBJECTIVE

To study the relationship between consumption of milk and milk products, calcium, lactose and vitamin D and occurrence of colorectal cancers.

DESIGN

Prospective cohort study.

SUBJECTS

A total of 9959 men and women aged 15 y or older without history of cancer at baseline. During a 24 y follow-up, 72 new cancers of the large bowel (38 in the colon and 34 in the rectum) were detected.

RESULTS

Consumption of milk and total milk products was suggested to be inversely related to colon cancer incidence, whereas no similar association was seen for rectal cancer. The relative risk between the highest and lowest quartiles of intake adjusted for potential confounding factors was 0.46 (95% confidence interval 0.14-1.46, P for trend 0.09) for milk and 0.37 (95% CI=0.12-1.39, P for trend 0.06) for total milk products. Lactose intake showed a similar inverse relationship with colon cancer: the relative risk was 0.31 (95% CI=0.08-1.15, P for trend 0.03). Intake of vitamin D or total dietary calcium was not significantly related to colorectal cancer risk, whereas calcium provided by fermented milk products was associated with increased colorectal cancer incidence; in the highest quartile the multivariate adjusted relative risk for colorectal cancer was 2.07 (95% CI=1.00-4.28).

CONCLUSIONS

Our results indicate that individuals showing high consumption of milk have a potentially reduced risk of colon cancer; however, the association does not appear to be due to intake of calcium, vitamin D, or to specific effects of fermented milk.

SPONSORSHIP

This study was supported by a grant from the Swedish Cancer Foundation.

Links

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  • Authors+Show Affiliations

    ,

    Department of Clinical Nutrition, University of Kuopio, PO Box 1627, Fin 70211 Kuopio, Finland. Ritva.Jarvinen@uku.fi

    , ,

    Source

    MeSH

    Adolescent
    Adult
    Calcium, Dietary
    Cohort Studies
    Colonic Neoplasms
    Colorectal Neoplasms
    Confounding Factors (Epidemiology)
    Dairy Products
    Female
    Follow-Up Studies
    Humans
    Incidence
    Male
    Prospective Studies
    Rectal Neoplasms
    Risk
    Risk Factors
    Sweden
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11641750

    Citation

    Järvinen, R, et al. "Prospective Study On Milk Products, Calcium and Cancers of the Colon and Rectum." European Journal of Clinical Nutrition, vol. 55, no. 11, 2001, pp. 1000-7.
    Järvinen R, Knekt P, Hakulinen T, et al. Prospective study on milk products, calcium and cancers of the colon and rectum. Eur J Clin Nutr. 2001;55(11):1000-7.
    Järvinen, R., Knekt, P., Hakulinen, T., & Aromaa, A. (2001). Prospective study on milk products, calcium and cancers of the colon and rectum. European Journal of Clinical Nutrition, 55(11), pp. 1000-7.
    Järvinen R, et al. Prospective Study On Milk Products, Calcium and Cancers of the Colon and Rectum. Eur J Clin Nutr. 2001;55(11):1000-7. PubMed PMID: 11641750.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prospective study on milk products, calcium and cancers of the colon and rectum. AU - Järvinen,R, AU - Knekt,P, AU - Hakulinen,T, AU - Aromaa,A, PY - 2000/11/06/received PY - 2001/04/24/revised PY - 2001/04/28/accepted PY - 2001/10/20/pubmed PY - 2002/1/5/medline PY - 2001/10/20/entrez SP - 1000 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 55 IS - 11 N2 - OBJECTIVE: To study the relationship between consumption of milk and milk products, calcium, lactose and vitamin D and occurrence of colorectal cancers. DESIGN: Prospective cohort study. SUBJECTS: A total of 9959 men and women aged 15 y or older without history of cancer at baseline. During a 24 y follow-up, 72 new cancers of the large bowel (38 in the colon and 34 in the rectum) were detected. RESULTS: Consumption of milk and total milk products was suggested to be inversely related to colon cancer incidence, whereas no similar association was seen for rectal cancer. The relative risk between the highest and lowest quartiles of intake adjusted for potential confounding factors was 0.46 (95% confidence interval 0.14-1.46, P for trend 0.09) for milk and 0.37 (95% CI=0.12-1.39, P for trend 0.06) for total milk products. Lactose intake showed a similar inverse relationship with colon cancer: the relative risk was 0.31 (95% CI=0.08-1.15, P for trend 0.03). Intake of vitamin D or total dietary calcium was not significantly related to colorectal cancer risk, whereas calcium provided by fermented milk products was associated with increased colorectal cancer incidence; in the highest quartile the multivariate adjusted relative risk for colorectal cancer was 2.07 (95% CI=1.00-4.28). CONCLUSIONS: Our results indicate that individuals showing high consumption of milk have a potentially reduced risk of colon cancer; however, the association does not appear to be due to intake of calcium, vitamin D, or to specific effects of fermented milk. SPONSORSHIP: This study was supported by a grant from the Swedish Cancer Foundation. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/11641750/Prospective_study_on_milk_products_calcium_and_cancers_of_the_colon_and_rectum_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601260 DB - PRIME DP - Unbound Medicine ER -