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[Stimulation of DNA synthesis and mitoses in the rat liver in experimental galactosemia caused by the prolonged administration of galactose].
Tsitologiia. 1975 Sep; 17(9):1042-6.T

Abstract

Feeding of rats with galactose-rich ration results in the activation of galactoso-1-phosphate-uridililtransferase in the liver after 2--4 days. By days 5--13, the activity of the enzyme decreased to the control level in spite of continued feeding of rats with galactose-rich ration. The activation of galactoso-1-phosphate-uridililtransferase occurred on the first 5 days of the experiment, whereas all proliferative activity in the liver increased from days 12--60, and the maximum mitotic was attained by the 20th and 50th days of feeding with galactose-rich diet. DNA synthesis also increased considerably, and this evidenced the increased H3-thymidine incorporation in hepatocyte nuclei. If one accept that the induction of enzyme transforming galactose to glucose is an adaptive response of cells (organism) to galactose in the diet, then the subsequent stage of adaptation would be hepatocyte proliferation.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

1166519

Citation

Kostyrev, O A., and N A. Solov'eva. "[Stimulation of DNA Synthesis and Mitoses in the Rat Liver in Experimental Galactosemia Caused By the Prolonged Administration of Galactose]." Tsitologiia, vol. 17, no. 9, 1975, pp. 1042-6.
Kostyrev OA, Solov'eva NA. [Stimulation of DNA synthesis and mitoses in the rat liver in experimental galactosemia caused by the prolonged administration of galactose]. Tsitologiia. 1975;17(9):1042-6.
Kostyrev, O. A., & Solov'eva, N. A. (1975). [Stimulation of DNA synthesis and mitoses in the rat liver in experimental galactosemia caused by the prolonged administration of galactose]. Tsitologiia, 17(9), 1042-6.
Kostyrev OA, Solov'eva NA. [Stimulation of DNA Synthesis and Mitoses in the Rat Liver in Experimental Galactosemia Caused By the Prolonged Administration of Galactose]. Tsitologiia. 1975;17(9):1042-6. PubMed PMID: 1166519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Stimulation of DNA synthesis and mitoses in the rat liver in experimental galactosemia caused by the prolonged administration of galactose]. AU - Kostyrev,O A, AU - Solov'eva,N A, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 1042 EP - 6 JF - Tsitologiia JO - Tsitologiia VL - 17 IS - 9 N2 - Feeding of rats with galactose-rich ration results in the activation of galactoso-1-phosphate-uridililtransferase in the liver after 2--4 days. By days 5--13, the activity of the enzyme decreased to the control level in spite of continued feeding of rats with galactose-rich ration. The activation of galactoso-1-phosphate-uridililtransferase occurred on the first 5 days of the experiment, whereas all proliferative activity in the liver increased from days 12--60, and the maximum mitotic was attained by the 20th and 50th days of feeding with galactose-rich diet. DNA synthesis also increased considerably, and this evidenced the increased H3-thymidine incorporation in hepatocyte nuclei. If one accept that the induction of enzyme transforming galactose to glucose is an adaptive response of cells (organism) to galactose in the diet, then the subsequent stage of adaptation would be hepatocyte proliferation. SN - 0041-3771 UR - https://www.unboundmedicine.com/medline/citation/1166519/[Stimulation_of_DNA_synthesis_and_mitoses_in_the_rat_liver_in_experimental_galactosemia_caused_by_the_prolonged_administration_of_galactose]_ DB - PRIME DP - Unbound Medicine ER -