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The treatment of internal anal sphincter achalasia with botulinum toxin.
Pediatr Surg Int. 2001 Sep; 17(7):521-3.PS

Abstract

Internal anal sphincter (IAS) achalasia is a disorder of defecation in which the IAS fails to relax. Botulinum toxin (BT), which has been successfully used to relax the anal and lower esophageal sphincters, was injected twice into the IAS of one adolescent and three infants with manometric, radiologic, and in 2 cases histochemical diagnosis of anal achalasia: in the adolescent a third injection was necessary. Spontaneous defecation was achieved in all patients following the second injection. In one case a diagnosis of short-segment Hirschsprung's disease was obtained after the second injection. Local infiltration of BT into the IAS proved effective in the treatment of IAS achalasia. Double-blind studies and longer follow-up periods are needed to better evaluate these preliminary results and define the limits of this promising therapy.

Authors+Show Affiliations

Department of Pediatric Surgery, IRCCS, Burlo Garofolo, Trieste, ItalyNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11666049

Citation

Messineo, A, et al. "The Treatment of Internal Anal Sphincter Achalasia With Botulinum Toxin." Pediatric Surgery International, vol. 17, no. 7, 2001, pp. 521-3.
Messineo A, Codrich D, Monai M, et al. The treatment of internal anal sphincter achalasia with botulinum toxin. Pediatr Surg Int. 2001;17(7):521-3.
Messineo, A., Codrich, D., Monai, M., Martellossi, S., & Ventura, A. (2001). The treatment of internal anal sphincter achalasia with botulinum toxin. Pediatric Surgery International, 17(7), 521-3.
Messineo A, et al. The Treatment of Internal Anal Sphincter Achalasia With Botulinum Toxin. Pediatr Surg Int. 2001;17(7):521-3. PubMed PMID: 11666049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The treatment of internal anal sphincter achalasia with botulinum toxin. AU - Messineo,A, AU - Codrich,D, AU - Monai,M, AU - Martellossi,S, AU - Ventura,A, PY - 2001/10/23/pubmed PY - 2002/1/24/medline PY - 2001/10/23/entrez SP - 521 EP - 3 JF - Pediatric surgery international JO - Pediatr Surg Int VL - 17 IS - 7 N2 - Internal anal sphincter (IAS) achalasia is a disorder of defecation in which the IAS fails to relax. Botulinum toxin (BT), which has been successfully used to relax the anal and lower esophageal sphincters, was injected twice into the IAS of one adolescent and three infants with manometric, radiologic, and in 2 cases histochemical diagnosis of anal achalasia: in the adolescent a third injection was necessary. Spontaneous defecation was achieved in all patients following the second injection. In one case a diagnosis of short-segment Hirschsprung's disease was obtained after the second injection. Local infiltration of BT into the IAS proved effective in the treatment of IAS achalasia. Double-blind studies and longer follow-up periods are needed to better evaluate these preliminary results and define the limits of this promising therapy. SN - 0179-0358 UR - https://www.unboundmedicine.com/medline/citation/11666049/The_treatment_of_internal_anal_sphincter_achalasia_with_botulinum_toxin_ L2 - https://doi.org/10.1007/s003830100583 DB - PRIME DP - Unbound Medicine ER -