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Antiepileptic drugs as independent predictors of plasma total homocysteine levels.
Epilepsy Res 2001; 47(1-2):27-35ER

Abstract

Low folate levels have consistently been reported in patients with epilepsy on phenytoin (PHT), phenobarbital (PB) and primidone (PRD), while data on valproate (VPA) are conflicting. Furthermore, antiepileptic drugs (AEDs) may be associated with high levels of plasma total homocysteine (p-tHcy). Therefore, we have investigated the levels of p-tHcy, serum folate (S-FA) and erythrocyte folate (E-FA) in patients on PHT, PB and PRD (Group 1, n=21) and VPA (Group 2, n=24). Both groups had their own matched controls. Blood samples were drawn fasting and 6 h post methionine loading (6 h-PML). The Group 1 patients had fasting and 6 h-PML p-tHcy levels significantly higher than their controls (P=0.05 and <0.0001, respectively), and patients without dietary multivitamin supplementation (n=14), had lower fasting S-FA and E-FA levels than their controls (P=0.02 and 0.0003, respectively). The Group 2 patients had fasting and 6 h-PML levels of p-tHcy, S-FA and E-FA not different from their controls. In a multiple stepwise regression model comprising all subjects (n=90), the AEDs of Group 1 and the S-FA levels were independent predictors of p-tHcy levels. Thus, PHT, PB and PRD are associated with high p-tHcy and low folate levels, whereas VPA does not influence S-FA, E-FA and p-tHcy levels in adult patients.

Authors+Show Affiliations

Department of Internal Medicine, Rogaland Central Hospital, 4011 Stavanger, Norway. apeland@online.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11673018

Citation

Apeland, T, et al. "Antiepileptic Drugs as Independent Predictors of Plasma Total Homocysteine Levels." Epilepsy Research, vol. 47, no. 1-2, 2001, pp. 27-35.
Apeland T, Mansoor MA, Strandjord RE. Antiepileptic drugs as independent predictors of plasma total homocysteine levels. Epilepsy Res. 2001;47(1-2):27-35.
Apeland, T., Mansoor, M. A., & Strandjord, R. E. (2001). Antiepileptic drugs as independent predictors of plasma total homocysteine levels. Epilepsy Research, 47(1-2), pp. 27-35.
Apeland T, Mansoor MA, Strandjord RE. Antiepileptic Drugs as Independent Predictors of Plasma Total Homocysteine Levels. Epilepsy Res. 2001;47(1-2):27-35. PubMed PMID: 11673018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiepileptic drugs as independent predictors of plasma total homocysteine levels. AU - Apeland,T, AU - Mansoor,M A, AU - Strandjord,R E, PY - 2001/10/24/pubmed PY - 2002/2/1/medline PY - 2001/10/24/entrez SP - 27 EP - 35 JF - Epilepsy research JO - Epilepsy Res. VL - 47 IS - 1-2 N2 - Low folate levels have consistently been reported in patients with epilepsy on phenytoin (PHT), phenobarbital (PB) and primidone (PRD), while data on valproate (VPA) are conflicting. Furthermore, antiepileptic drugs (AEDs) may be associated with high levels of plasma total homocysteine (p-tHcy). Therefore, we have investigated the levels of p-tHcy, serum folate (S-FA) and erythrocyte folate (E-FA) in patients on PHT, PB and PRD (Group 1, n=21) and VPA (Group 2, n=24). Both groups had their own matched controls. Blood samples were drawn fasting and 6 h post methionine loading (6 h-PML). The Group 1 patients had fasting and 6 h-PML p-tHcy levels significantly higher than their controls (P=0.05 and <0.0001, respectively), and patients without dietary multivitamin supplementation (n=14), had lower fasting S-FA and E-FA levels than their controls (P=0.02 and 0.0003, respectively). The Group 2 patients had fasting and 6 h-PML levels of p-tHcy, S-FA and E-FA not different from their controls. In a multiple stepwise regression model comprising all subjects (n=90), the AEDs of Group 1 and the S-FA levels were independent predictors of p-tHcy levels. Thus, PHT, PB and PRD are associated with high p-tHcy and low folate levels, whereas VPA does not influence S-FA, E-FA and p-tHcy levels in adult patients. SN - 0920-1211 UR - https://www.unboundmedicine.com/medline/citation/11673018/Antiepileptic_drugs_as_independent_predictors_of_plasma_total_homocysteine_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-1211(01)00288-1 DB - PRIME DP - Unbound Medicine ER -