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[Mania during the use of a combination preparation with St. John's wort (Hypericum perforatum)].
Ned Tijdschr Geneeskd 2001; 145(40):1943-5NT

Abstract

A 23-year-old woman with no psychiatric history developed acute mania and psychosis while using St. John's wort at a high dosage (Valdispert 'balans', a combination of valerian extract and hypericin). She was diagnosed as having substance-induced mood disorder, with manic features (DSM-IV). Discontinuation of the use of the product and treatment with olanzapine led to complete recovery. No causal relationship between the use of the extract and the mania was established, but the course of the mania does suggest this association. St. John's wort is a popular herbal antidepressant. Hyperforin and hypericin, components of St. John's wort, inhibit synaptosomal serotonin, noradrenaline and dopamine uptake. The mechanism of action of St. John's wort is, however, not yet fully understood. St. John's wort should therefore be used with caution, especially in patients with a bipolar disorder.

Authors+Show Affiliations

Academisch Medisch Centrum, Postbus 22.700, 1100 DE Amsterdam. y.guzelcan@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

dut

PubMed ID

11675976

Citation

Güzelcan, Y, et al. "[Mania During the Use of a Combination Preparation With St. John's Wort (Hypericum Perforatum)]." Nederlands Tijdschrift Voor Geneeskunde, vol. 145, no. 40, 2001, pp. 1943-5.
Güzelcan Y, Scholte WF, Assies J, et al. [Mania during the use of a combination preparation with St. John's wort (Hypericum perforatum)]. Ned Tijdschr Geneeskd. 2001;145(40):1943-5.
Güzelcan, Y., Scholte, W. F., Assies, J., & Becker, H. E. (2001). [Mania during the use of a combination preparation with St. John's wort (Hypericum perforatum)]. Nederlands Tijdschrift Voor Geneeskunde, 145(40), pp. 1943-5.
Güzelcan Y, et al. [Mania During the Use of a Combination Preparation With St. John's Wort (Hypericum Perforatum)]. Ned Tijdschr Geneeskd. 2001 Oct 6;145(40):1943-5. PubMed PMID: 11675976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Mania during the use of a combination preparation with St. John's wort (Hypericum perforatum)]. AU - Güzelcan,Y, AU - Scholte,W F, AU - Assies,J, AU - Becker,H E, PY - 2001/10/26/pubmed PY - 2002/1/5/medline PY - 2001/10/26/entrez SP - 1943 EP - 5 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 145 IS - 40 N2 - A 23-year-old woman with no psychiatric history developed acute mania and psychosis while using St. John's wort at a high dosage (Valdispert 'balans', a combination of valerian extract and hypericin). She was diagnosed as having substance-induced mood disorder, with manic features (DSM-IV). Discontinuation of the use of the product and treatment with olanzapine led to complete recovery. No causal relationship between the use of the extract and the mania was established, but the course of the mania does suggest this association. St. John's wort is a popular herbal antidepressant. Hyperforin and hypericin, components of St. John's wort, inhibit synaptosomal serotonin, noradrenaline and dopamine uptake. The mechanism of action of St. John's wort is, however, not yet fully understood. St. John's wort should therefore be used with caution, especially in patients with a bipolar disorder. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/11675976/[Mania_during_the_use_of_a_combination_preparation_with_St__John's_wort__Hypericum_perforatum_]_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -