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Linezolid treatment of prosthetic hip Infections due to methicillin-resistant Staphylococcus aureus (MRSA).
J Infect 2001; 43(2):148-9JI

Abstract

Prosthetic joint infection is an infrequent but serious complication of total joint arthroplasty. Complete removal of all foreign material is essential, however when prosthesis removal is not possible or contraindicated, suppressive antibiotic therapy with retention of the functioning hip arthroplasty may be considered. Linezolid, the first approved oxazolidinone, appears to be a promising new agent for the treatment of serious Gram-positive infections. We report two cases of Methicillin-resistant Staphylococcus aureus (MRSA) prosthetic hip infections successfully treated with a long course of linezolid. This observation suggest that linezolid is a promising drug for the treatment of prosthetic joint infections due to MRSA or other Gram-positive pathogens, particularly when other therapeutic approaches are not feasible or a long-term antibiotic therapy is required.

Authors+Show Affiliations

Department of Infectious Disease, University of Genoa School of Medicine, San Martino Hospital, Genoa, Italy. mattba@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11676523

Citation

Bassetti, M, et al. "Linezolid Treatment of Prosthetic Hip Infections Due to Methicillin-resistant Staphylococcus Aureus (MRSA)." The Journal of Infection, vol. 43, no. 2, 2001, pp. 148-9.
Bassetti M, Di Biagio A, Cenderello G, et al. Linezolid treatment of prosthetic hip Infections due to methicillin-resistant Staphylococcus aureus (MRSA). J Infect. 2001;43(2):148-9.
Bassetti, M., Di Biagio, A., Cenderello, G., Del Bono, V., Palermo, A., Cruciani, M., & Bassetti, D. (2001). Linezolid treatment of prosthetic hip Infections due to methicillin-resistant Staphylococcus aureus (MRSA). The Journal of Infection, 43(2), pp. 148-9.
Bassetti M, et al. Linezolid Treatment of Prosthetic Hip Infections Due to Methicillin-resistant Staphylococcus Aureus (MRSA). J Infect. 2001;43(2):148-9. PubMed PMID: 11676523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linezolid treatment of prosthetic hip Infections due to methicillin-resistant Staphylococcus aureus (MRSA). AU - Bassetti,M, AU - Di Biagio,A, AU - Cenderello,G, AU - Del Bono,V, AU - Palermo,A, AU - Cruciani,M, AU - Bassetti,D, PY - 2001/10/26/pubmed PY - 2002/1/23/medline PY - 2001/10/26/entrez SP - 148 EP - 9 JF - The Journal of infection JO - J. Infect. VL - 43 IS - 2 N2 - Prosthetic joint infection is an infrequent but serious complication of total joint arthroplasty. Complete removal of all foreign material is essential, however when prosthesis removal is not possible or contraindicated, suppressive antibiotic therapy with retention of the functioning hip arthroplasty may be considered. Linezolid, the first approved oxazolidinone, appears to be a promising new agent for the treatment of serious Gram-positive infections. We report two cases of Methicillin-resistant Staphylococcus aureus (MRSA) prosthetic hip infections successfully treated with a long course of linezolid. This observation suggest that linezolid is a promising drug for the treatment of prosthetic joint infections due to MRSA or other Gram-positive pathogens, particularly when other therapeutic approaches are not feasible or a long-term antibiotic therapy is required. SN - 0163-4453 UR - https://www.unboundmedicine.com/medline/citation/11676523/Linezolid_treatment_of_prosthetic_hip_Infections_due_to_methicillin_resistant_Staphylococcus_aureus__MRSA__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(01)90863-1 DB - PRIME DP - Unbound Medicine ER -