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Lupus pregnancy: is heparin a risk factor for osteoporosis?
Lupus 2001; 10(9):597-600L

Abstract

Regulation of calcium homeostasis during pregnancy is complex. Clinically significant bone mass loss is infrequent; however a subset of women may develop symptomatic osteoporosis related to pregnancy. Lactation is a period of special risk for bone loss. Whatever the effect of heparin on bone loss, vertebral fractures are rare in women treated with heparin during pregnancy. Low molecular weight heparins may have a less deleterious effect on bone than unfractionated heparin. Women with autoimmune diseases, particularly those with lupus and/or the antiphospholipid syndrome may receive heparin throughout pregnancy. Corticosteroids must be reduced as much as possible in these women, and calcium plus vitamin D are recommended. Finally, indications for heparin use must be clearly justified and advice regarding breastfeeding must be offered.

Authors+Show Affiliations

Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11678446

Citation

Ruiz-Irastorza, G, et al. "Lupus Pregnancy: Is Heparin a Risk Factor for Osteoporosis?" Lupus, vol. 10, no. 9, 2001, pp. 597-600.
Ruiz-Irastorza G, Khamashta MA, Nelson-Piercy C, et al. Lupus pregnancy: is heparin a risk factor for osteoporosis? Lupus. 2001;10(9):597-600.
Ruiz-Irastorza, G., Khamashta, M. A., Nelson-Piercy, C., & Hughes, G. R. (2001). Lupus pregnancy: is heparin a risk factor for osteoporosis? Lupus, 10(9), pp. 597-600.
Ruiz-Irastorza G, et al. Lupus Pregnancy: Is Heparin a Risk Factor for Osteoporosis. Lupus. 2001;10(9):597-600. PubMed PMID: 11678446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lupus pregnancy: is heparin a risk factor for osteoporosis? AU - Ruiz-Irastorza,G, AU - Khamashta,M A, AU - Nelson-Piercy,C, AU - Hughes,G R, PY - 2001/10/27/pubmed PY - 2002/3/22/medline PY - 2001/10/27/entrez SP - 597 EP - 600 JF - Lupus JO - Lupus VL - 10 IS - 9 N2 - Regulation of calcium homeostasis during pregnancy is complex. Clinically significant bone mass loss is infrequent; however a subset of women may develop symptomatic osteoporosis related to pregnancy. Lactation is a period of special risk for bone loss. Whatever the effect of heparin on bone loss, vertebral fractures are rare in women treated with heparin during pregnancy. Low molecular weight heparins may have a less deleterious effect on bone than unfractionated heparin. Women with autoimmune diseases, particularly those with lupus and/or the antiphospholipid syndrome may receive heparin throughout pregnancy. Corticosteroids must be reduced as much as possible in these women, and calcium plus vitamin D are recommended. Finally, indications for heparin use must be clearly justified and advice regarding breastfeeding must be offered. SN - 0961-2033 UR - https://www.unboundmedicine.com/medline/citation/11678446/Lupus_pregnancy:_is_heparin_a_risk_factor_for_osteoporosis L2 - http://journals.sagepub.com/doi/full/10.1191/096120301682430168?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -