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Prevalence of immunoglobulin E for fungi in atopic children.
Clin Exp Allergy. 2001 Oct; 31(10):1564-70.CE

Abstract

BACKGROUND

The prevalence of sensitization to fungi in young atopic patients in relation to age and clinical importance is largely unknown.

OBJECTIVE

The aim of this study was to investigate the prevalence of sensitization to different fungi in atopic children in relation to age and other aeroallergens.

METHODS

A total of 137 atopic children (male 62%, female 38%; mean age 5 years and 9 months, range 5 months-14 years) were studied. Sera of all patients were routinely tested for total IgE and specific IgE against aeroallergens and milk. Positive sera were also tested for IgE against Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum and Penicillium chrysogenum, using the Pharmacia Enzyme CAP procedure.

RESULTS

In this study in atopic children total IgE showed a significant linear relation with age, whereas specific IgE against outdoor fungi, indoor fungi and house dust mite showed significant non-linearity with age. Prevalence of specific IgE for Cladosporium ranked first, followed closely by Aspergillus and Alternaria. Calculation of the sensitization of indoor and outdoor fungi showed maximum prevalence at 7.8 years, followed by lower values at higher ages. A similar significant relation was also found for Alternaria, while this relation was not significant for the other individual fungi. Specific IgE for indoor and outdoor fungi was associated with the presence of specific IgE for aeroallergen and milk. We found that all children aged 4 years and older showed IgE for house dust mite that did not decline with increasing age.

CONCLUSIONS

Sensitization to fungi is prevalent in childhood, with an age-dependent distribution reaching maximum values at 7.7-7.8 years, followed by a decline for all fungal sensitization with increasing age. The importance and relative contribution of fungal sensitization to airway disease, compared with the other allergens, remains to be established.

Authors+Show Affiliations

Department of Paediatric Pulmonology, University Hospital, Groningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11678856

Citation

Nolles, G, et al. "Prevalence of Immunoglobulin E for Fungi in Atopic Children." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 31, no. 10, 2001, pp. 1564-70.
Nolles G, Hoekstra MO, Schouten JP, et al. Prevalence of immunoglobulin E for fungi in atopic children. Clin Exp Allergy. 2001;31(10):1564-70.
Nolles, G., Hoekstra, M. O., Schouten, J. P., Gerritsen, J., & Kauffman, H. F. (2001). Prevalence of immunoglobulin E for fungi in atopic children. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 31(10), 1564-70.
Nolles G, et al. Prevalence of Immunoglobulin E for Fungi in Atopic Children. Clin Exp Allergy. 2001;31(10):1564-70. PubMed PMID: 11678856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of immunoglobulin E for fungi in atopic children. AU - Nolles,G, AU - Hoekstra,M O, AU - Schouten,J P, AU - Gerritsen,J, AU - Kauffman,H F, PY - 2001/10/27/pubmed PY - 2002/1/5/medline PY - 2001/10/27/entrez SP - 1564 EP - 70 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 31 IS - 10 N2 - BACKGROUND: The prevalence of sensitization to fungi in young atopic patients in relation to age and clinical importance is largely unknown. OBJECTIVE: The aim of this study was to investigate the prevalence of sensitization to different fungi in atopic children in relation to age and other aeroallergens. METHODS: A total of 137 atopic children (male 62%, female 38%; mean age 5 years and 9 months, range 5 months-14 years) were studied. Sera of all patients were routinely tested for total IgE and specific IgE against aeroallergens and milk. Positive sera were also tested for IgE against Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum and Penicillium chrysogenum, using the Pharmacia Enzyme CAP procedure. RESULTS: In this study in atopic children total IgE showed a significant linear relation with age, whereas specific IgE against outdoor fungi, indoor fungi and house dust mite showed significant non-linearity with age. Prevalence of specific IgE for Cladosporium ranked first, followed closely by Aspergillus and Alternaria. Calculation of the sensitization of indoor and outdoor fungi showed maximum prevalence at 7.8 years, followed by lower values at higher ages. A similar significant relation was also found for Alternaria, while this relation was not significant for the other individual fungi. Specific IgE for indoor and outdoor fungi was associated with the presence of specific IgE for aeroallergen and milk. We found that all children aged 4 years and older showed IgE for house dust mite that did not decline with increasing age. CONCLUSIONS: Sensitization to fungi is prevalent in childhood, with an age-dependent distribution reaching maximum values at 7.7-7.8 years, followed by a decline for all fungal sensitization with increasing age. The importance and relative contribution of fungal sensitization to airway disease, compared with the other allergens, remains to be established. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/11678856/Prevalence_of_immunoglobulin_E_for_fungi_in_atopic_children_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2001&volume=31&issue=10&spage=1564 DB - PRIME DP - Unbound Medicine ER -