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Beneficial effects of quercetin on oxidative stress induced by ultraviolet A.
Clin Exp Dermatol. 2001 Sep; 26(6):536-9.CE

Abstract

Cells exposed to ultraviolet A (UVA) radiation can induce the production of reactive oxygen species (ROS) that may damage cellular elements. By contrast, antioxidants can reduce production of ROS. To assess these cellular events in a model system, rats were divided into three groups comprising control (C), ultraviolet exposed (UV), and ultraviolet exposed and quercetin-treated (UV + Q). UV and UV + Q group rats were irradiated 4 h/day with UVA radiation (1.25 mW/cm2) for 9 days. In the UV + Q group rats quercetin (50 mg/kg body weight) was administered intraperitoneally before irradiation. The levels of malondialdehyde (MDA) were increased significantly following irradiation (P < 0.001). In the UV + Q group MDA levels declined significantly compared with the UV group (P < 0.001). With respect to levels of glutathione (GSH), no statistically significant changes were found between the control and the UV group. The GSH levels in the UV + Q group were slightly higher than those of the control and UV groups, but not significantly so. The enzyme activities of glutathione peroxidase, glutathione reductase, catalase and superoxide dismutase decreased significantly after irradiation (P < 0.001). In the UV + Q group all of these enzyme activities were found to be considerably higher than those in the UV group (P < 0.001). This study demonstrates that exposure of rats to UVA leads to oxidative stress as reflected by increased MDA levels and reduced enzymatic antioxidant levels. It also shows that quercetin may be useful in reducing or preventing photobiologic damage.

Authors+Show Affiliations

Department of Biochemistry, The Medical School, Osmangazi University, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11678884

Citation

Erden Inal, M, et al. "Beneficial Effects of Quercetin On Oxidative Stress Induced By Ultraviolet A." Clinical and Experimental Dermatology, vol. 26, no. 6, 2001, pp. 536-9.
Erden Inal M, Kahraman A, Köken T. Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clin Exp Dermatol. 2001;26(6):536-9.
Erden Inal, M., Kahraman, A., & Köken, T. (2001). Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clinical and Experimental Dermatology, 26(6), 536-9.
Erden Inal M, Kahraman A, Köken T. Beneficial Effects of Quercetin On Oxidative Stress Induced By Ultraviolet A. Clin Exp Dermatol. 2001;26(6):536-9. PubMed PMID: 11678884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. AU - Erden Inal,M, AU - Kahraman,A, AU - Köken,T, PY - 2001/10/27/pubmed PY - 2002/1/5/medline PY - 2001/10/27/entrez SP - 536 EP - 9 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 26 IS - 6 N2 - Cells exposed to ultraviolet A (UVA) radiation can induce the production of reactive oxygen species (ROS) that may damage cellular elements. By contrast, antioxidants can reduce production of ROS. To assess these cellular events in a model system, rats were divided into three groups comprising control (C), ultraviolet exposed (UV), and ultraviolet exposed and quercetin-treated (UV + Q). UV and UV + Q group rats were irradiated 4 h/day with UVA radiation (1.25 mW/cm2) for 9 days. In the UV + Q group rats quercetin (50 mg/kg body weight) was administered intraperitoneally before irradiation. The levels of malondialdehyde (MDA) were increased significantly following irradiation (P < 0.001). In the UV + Q group MDA levels declined significantly compared with the UV group (P < 0.001). With respect to levels of glutathione (GSH), no statistically significant changes were found between the control and the UV group. The GSH levels in the UV + Q group were slightly higher than those of the control and UV groups, but not significantly so. The enzyme activities of glutathione peroxidase, glutathione reductase, catalase and superoxide dismutase decreased significantly after irradiation (P < 0.001). In the UV + Q group all of these enzyme activities were found to be considerably higher than those in the UV group (P < 0.001). This study demonstrates that exposure of rats to UVA leads to oxidative stress as reflected by increased MDA levels and reduced enzymatic antioxidant levels. It also shows that quercetin may be useful in reducing or preventing photobiologic damage. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/11678884/Beneficial_effects_of_quercetin_on_oxidative_stress_induced_by_ultraviolet_A_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0307-6938&amp;date=2001&amp;volume=26&amp;issue=6&amp;spage=536 DB - PRIME DP - Unbound Medicine ER -