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Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.

Abstract

OBJECTIVE

Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder.

METHODS

The study was performed on 36 out-patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial.

RESULTS

Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam.

CONCLUSION

The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage. A large-scale trial is justified.

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  • Authors+Show Affiliations

    ,

    Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran, Iran. s.akhond@neda.net

    , , , ,

    Source

    MeSH

    Adult
    Anti-Anxiety Agents
    Anxiety Disorders
    Ataxia
    Dizziness
    Double-Blind Method
    Female
    Humans
    Hypersensitivity
    Male
    Oxazepam
    Passiflora
    Phytotherapy
    Plant Extracts
    Task Performance and Analysis

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    11679026

    Citation

    Akhondzadeh, S, et al. "Passionflower in the Treatment of Generalized Anxiety: a Pilot Double-blind Randomized Controlled Trial With Oxazepam." Journal of Clinical Pharmacy and Therapeutics, vol. 26, no. 5, 2001, pp. 363-7.
    Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001;26(5):363-7.
    Akhondzadeh, S., Naghavi, H. R., Vazirian, M., Shayeganpour, A., Rashidi, H., & Khani, M. (2001). Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics, 26(5), pp. 363-7.
    Akhondzadeh S, et al. Passionflower in the Treatment of Generalized Anxiety: a Pilot Double-blind Randomized Controlled Trial With Oxazepam. J Clin Pharm Ther. 2001;26(5):363-7. PubMed PMID: 11679026.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. AU - Akhondzadeh,S, AU - Naghavi,H R, AU - Vazirian,M, AU - Shayeganpour,A, AU - Rashidi,H, AU - Khani,M, PY - 2001/10/27/pubmed PY - 2002/1/5/medline PY - 2001/10/27/entrez SP - 363 EP - 7 JF - Journal of clinical pharmacy and therapeutics JO - J Clin Pharm Ther VL - 26 IS - 5 N2 - OBJECTIVE: Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder. METHODS: The study was performed on 36 out-patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial. RESULTS: Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam. CONCLUSION: The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage. A large-scale trial is justified. SN - 0269-4727 UR - https://www.unboundmedicine.com/medline/citation/11679026/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-4727&date=2001&volume=26&issue=5&spage=363 DB - PRIME DP - Unbound Medicine ER -