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Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.
J Clin Pharm Ther 2001; 26(5):363-7JC

Abstract

OBJECTIVE

Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder.

METHODS

The study was performed on 36 out-patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial.

RESULTS

Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam.

CONCLUSION

The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage. A large-scale trial is justified.

Authors+Show Affiliations

Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran, Iran. s.akhond@neda.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11679026

Citation

Akhondzadeh, S, et al. "Passionflower in the Treatment of Generalized Anxiety: a Pilot Double-blind Randomized Controlled Trial With Oxazepam." Journal of Clinical Pharmacy and Therapeutics, vol. 26, no. 5, 2001, pp. 363-7.
Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001;26(5):363-7.
Akhondzadeh, S., Naghavi, H. R., Vazirian, M., Shayeganpour, A., Rashidi, H., & Khani, M. (2001). Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics, 26(5), pp. 363-7.
Akhondzadeh S, et al. Passionflower in the Treatment of Generalized Anxiety: a Pilot Double-blind Randomized Controlled Trial With Oxazepam. J Clin Pharm Ther. 2001;26(5):363-7. PubMed PMID: 11679026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. AU - Akhondzadeh,S, AU - Naghavi,H R, AU - Vazirian,M, AU - Shayeganpour,A, AU - Rashidi,H, AU - Khani,M, PY - 2001/10/27/pubmed PY - 2002/1/5/medline PY - 2001/10/27/entrez SP - 363 EP - 7 JF - Journal of clinical pharmacy and therapeutics JO - J Clin Pharm Ther VL - 26 IS - 5 N2 - OBJECTIVE: Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder. METHODS: The study was performed on 36 out-patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial. RESULTS: Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam. CONCLUSION: The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage. A large-scale trial is justified. SN - 0269-4727 UR - https://www.unboundmedicine.com/medline/citation/11679026/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-4727&date=2001&volume=26&issue=5&spage=363 DB - PRIME DP - Unbound Medicine ER -