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Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission.

Abstract

Noradrenergic and dopaminergic mechanisms have been proposed for the pathophysiology of seasonal affective disorder (SAD). We investigated the effects of catecholamine depletion using alpha-methyl-para-tyrosine (AMPT), an inhibitor of tyrosine hydroxylase, in patients with SAD in natural summer remission. Nine drug-free patients with SAD by DSM-IV criteria, in summer remission for at least eight weeks, completed a double-blind, crossover study. Behavioral ratings and serum HVA and MHPG levels were obtained for 3-day sessions during which patients took AMPT or an active control drug, diphenhydramine. The active AMPT session significantly reduced serum levels of HVA and MHPG compared with the control diphenhydramine session. The AMPT session resulted in higher depression ratings with all nine patients having significant clinical relapse, compared with two patients during the diphenhydramine session. All patients returned to baseline scores after drug discontinuation. Catecholamine depletion results in significant clinical relapse in patients with SAD in the untreated, summer-remitted state. AMPT-induced depressive relapse may be a trait marker for SAD, and/or brain catecholamines may play a direct role in the pathogenesis of SAD.

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  • Authors+Show Affiliations

    ,

    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, B.C., Canada. rlam@interchange.ubc.ca

    , ,

    Source

    MeSH

    Affect
    Catecholamines
    Cross-Over Studies
    Dopamine
    Double-Blind Method
    Enzyme Inhibitors
    Female
    Humans
    Male
    Norepinephrine
    Remission, Spontaneous
    Seasonal Affective Disorder
    Seasons
    Tyrosine 3-Monooxygenase
    alpha-Methyltyrosine

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11682283

    Citation

    Lam, R W., et al. "Effects of Alpha-methyl-para-tyrosine-induced Catecholamine Depletion in Patients With Seasonal Affective Disorder in Summer Remission." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 25, no. 5 Suppl, 2001, pp. S97-101.
    Lam RW, Tam EM, Grewal A, et al. Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission. Neuropsychopharmacology. 2001;25(5 Suppl):S97-101.
    Lam, R. W., Tam, E. M., Grewal, A., & Yatham, L. N. (2001). Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 25(5 Suppl), pp. S97-101.
    Lam RW, et al. Effects of Alpha-methyl-para-tyrosine-induced Catecholamine Depletion in Patients With Seasonal Affective Disorder in Summer Remission. Neuropsychopharmacology. 2001;25(5 Suppl):S97-101. PubMed PMID: 11682283.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission. AU - Lam,R W, AU - Tam,E M, AU - Grewal,A, AU - Yatham,L N, PY - 2001/10/30/pubmed PY - 2002/1/5/medline PY - 2001/10/30/entrez SP - S97 EP - 101 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 25 IS - 5 Suppl N2 - Noradrenergic and dopaminergic mechanisms have been proposed for the pathophysiology of seasonal affective disorder (SAD). We investigated the effects of catecholamine depletion using alpha-methyl-para-tyrosine (AMPT), an inhibitor of tyrosine hydroxylase, in patients with SAD in natural summer remission. Nine drug-free patients with SAD by DSM-IV criteria, in summer remission for at least eight weeks, completed a double-blind, crossover study. Behavioral ratings and serum HVA and MHPG levels were obtained for 3-day sessions during which patients took AMPT or an active control drug, diphenhydramine. The active AMPT session significantly reduced serum levels of HVA and MHPG compared with the control diphenhydramine session. The AMPT session resulted in higher depression ratings with all nine patients having significant clinical relapse, compared with two patients during the diphenhydramine session. All patients returned to baseline scores after drug discontinuation. Catecholamine depletion results in significant clinical relapse in patients with SAD in the untreated, summer-remitted state. AMPT-induced depressive relapse may be a trait marker for SAD, and/or brain catecholamines may play a direct role in the pathogenesis of SAD. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/11682283/Effects_of_alpha_methyl_para_tyrosine_induced_catecholamine_depletion_in_patients_with_seasonal_affective_disorder_in_summer_remission_ L2 - http://dx.doi.org/10.1016/S0893-133X(01)00337-2 DB - PRIME DP - Unbound Medicine ER -