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Ultrastructural features of viral leukoencephalomyelitis of goats.
Lab Invest. 1975 Mar; 32(3):359-65.LI

Abstract

Ultrastructural studies were made of the central nervous system of three goats during the early stages of viral leukoencephalomyelitis of goats and of one goat 3 years after onset of the disease. In both early and late lesions, the following features were recognized: loss of myelin from normal axons, separation of the myelin sheath from the axon by cell processes, pronounced astrocytosis with numerous cell processes packed with heavy fibrils, paucity of oligodendrocytes, normal capillaries, and normal cellular elements in the adjacent gray matter. Early lesions also had many cells of the lymphoid series infiltrating perivascular spaces, within lesions, and, particularly, along axons undergoing demyelination. Although viral particles were extensively sought, only one suspect structure, with a tubular nucleocapsid-like configuration, was seen. Individual tubules of this particle measured 22 nm. in diameter. The ultrastructural features of demyelination in viral leukoencephalomyelitis of goats were compared with those described for demyelination that occurs in multiple sclerosis, experimental allergic encephalomyelitis, canine distemper encephalomyelitis, and that produced by diphtheria toxin.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1168292

Citation

Cork, L C., and W C. Davis. "Ultrastructural Features of Viral Leukoencephalomyelitis of Goats." Laboratory Investigation; a Journal of Technical Methods and Pathology, vol. 32, no. 3, 1975, pp. 359-65.
Cork LC, Davis WC. Ultrastructural features of viral leukoencephalomyelitis of goats. Lab Invest. 1975;32(3):359-65.
Cork, L. C., & Davis, W. C. (1975). Ultrastructural features of viral leukoencephalomyelitis of goats. Laboratory Investigation; a Journal of Technical Methods and Pathology, 32(3), 359-65.
Cork LC, Davis WC. Ultrastructural Features of Viral Leukoencephalomyelitis of Goats. Lab Invest. 1975;32(3):359-65. PubMed PMID: 1168292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrastructural features of viral leukoencephalomyelitis of goats. AU - Cork,L C, AU - Davis,W C, PY - 1975/3/1/pubmed PY - 1975/3/1/medline PY - 1975/3/1/entrez SP - 359 EP - 65 JF - Laboratory investigation; a journal of technical methods and pathology JO - Lab. Invest. VL - 32 IS - 3 N2 - Ultrastructural studies were made of the central nervous system of three goats during the early stages of viral leukoencephalomyelitis of goats and of one goat 3 years after onset of the disease. In both early and late lesions, the following features were recognized: loss of myelin from normal axons, separation of the myelin sheath from the axon by cell processes, pronounced astrocytosis with numerous cell processes packed with heavy fibrils, paucity of oligodendrocytes, normal capillaries, and normal cellular elements in the adjacent gray matter. Early lesions also had many cells of the lymphoid series infiltrating perivascular spaces, within lesions, and, particularly, along axons undergoing demyelination. Although viral particles were extensively sought, only one suspect structure, with a tubular nucleocapsid-like configuration, was seen. Individual tubules of this particle measured 22 nm. in diameter. The ultrastructural features of demyelination in viral leukoencephalomyelitis of goats were compared with those described for demyelination that occurs in multiple sclerosis, experimental allergic encephalomyelitis, canine distemper encephalomyelitis, and that produced by diphtheria toxin. SN - 0023-6837 UR - https://www.unboundmedicine.com/medline/citation/1168292/Ultrastructural_features_of_viral_leukoencephalomyelitis_of_goats_ L2 - https://medlineplus.gov/viralinfections.html DB - PRIME DP - Unbound Medicine ER -