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Caffeine eliminates psychomotor vigilance deficits from sleep inertia.
Sleep 2001; 24(7):813-9S

Abstract

STUDY OBJECTIVES

This study sought to establish the effects of caffeine on sleep inertia, which is the ubiquitous phenomenon of cognitive performance impairment, grogginess and tendency to return to sleep immediately after awakening.

DESIGN

28 normal adult volunteers were administered sustained low-dose caffeine or placebo (randomized double-blind) during the last 66 hours of an 88-hour period of extended wakefulness that included seven 2-hour naps during which polysomnographical recordings were made. Every 2 hours of wakefulness, and immediately after abrupt awakening from the naps, psychomotor vigilance performance was tested.

SETTING

N/A.

PARTICIPANTS

N/A.

INTERVENTIONS

N/A.

MEASUREMENTS AND RESULTS

In the placebo condition, sleep inertia was manifested as significantly impaired psychomotor vigilance upon awakening from the naps. This impairment was absent in the caffeine condition. Caffeine had only modest effects on nap sleep.

CONCLUSIONS

Caffeine was efficacious in overcoming sleep inertia. This suggests a reason for the popularity of caffeine-containing beverages after awakening. Caffeine's main mechanism of action on the central nervous system is antagonism of adenosine receptors. Thus, increased adenosine in the brain upon awakening may be the cause of sleep inertia.

Authors+Show Affiliations

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA. vdongen@mail.med.upenn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11683484

Citation

Van Dongen, H P., et al. "Caffeine Eliminates Psychomotor Vigilance Deficits From Sleep Inertia." Sleep, vol. 24, no. 7, 2001, pp. 813-9.
Van Dongen HP, Price NJ, Mullington JM, et al. Caffeine eliminates psychomotor vigilance deficits from sleep inertia. Sleep. 2001;24(7):813-9.
Van Dongen, H. P., Price, N. J., Mullington, J. M., Szuba, M. P., Kapoor, S. C., & Dinges, D. F. (2001). Caffeine eliminates psychomotor vigilance deficits from sleep inertia. Sleep, 24(7), pp. 813-9.
Van Dongen HP, et al. Caffeine Eliminates Psychomotor Vigilance Deficits From Sleep Inertia. Sleep. 2001 Nov 1;24(7):813-9. PubMed PMID: 11683484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine eliminates psychomotor vigilance deficits from sleep inertia. AU - Van Dongen,H P, AU - Price,N J, AU - Mullington,J M, AU - Szuba,M P, AU - Kapoor,S C, AU - Dinges,D F, PY - 2001/10/31/pubmed PY - 2002/2/8/medline PY - 2001/10/31/entrez KW - Non-programmatic SP - 813 EP - 9 JF - Sleep JO - Sleep VL - 24 IS - 7 N2 - STUDY OBJECTIVES: This study sought to establish the effects of caffeine on sleep inertia, which is the ubiquitous phenomenon of cognitive performance impairment, grogginess and tendency to return to sleep immediately after awakening. DESIGN: 28 normal adult volunteers were administered sustained low-dose caffeine or placebo (randomized double-blind) during the last 66 hours of an 88-hour period of extended wakefulness that included seven 2-hour naps during which polysomnographical recordings were made. Every 2 hours of wakefulness, and immediately after abrupt awakening from the naps, psychomotor vigilance performance was tested. SETTING: N/A. PARTICIPANTS: N/A. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: In the placebo condition, sleep inertia was manifested as significantly impaired psychomotor vigilance upon awakening from the naps. This impairment was absent in the caffeine condition. Caffeine had only modest effects on nap sleep. CONCLUSIONS: Caffeine was efficacious in overcoming sleep inertia. This suggests a reason for the popularity of caffeine-containing beverages after awakening. Caffeine's main mechanism of action on the central nervous system is antagonism of adenosine receptors. Thus, increased adenosine in the brain upon awakening may be the cause of sleep inertia. SN - 0161-8105 UR - https://www.unboundmedicine.com/medline/citation/11683484/full_citation/Caffeine_eliminates_psychomotor_vigilance_deficits_from_sleep_inertia L2 - https://academic.oup.com/sleep/article-lookup/doi/10.1093/sleep/24.7.813 DB - PRIME DP - Unbound Medicine ER -