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Effect of dietary linoleic acid concentration and vitamin E supplementation on cell desquamation and susceptibility to oxidative damage of pig jejunal mucosa.
J Anim Physiol Anim Nutr (Berl). 2001 Feb; 85(1-2):22-8.JA

Abstract

Sixty Large White x Great York pigs weighing approximately 60 kg were individually fed on six experimental diets. The experiment was organized in a 3 x 2 factorial arrangement design with three different fat sources and a basal or supplemented (200 mg/kg diet) level of alpha-tocopheryl acetate. All diets contained the same concentration of saturated fatty acids (15 +/- 0.2 g/kg dry matter) but differed in the concentration of C18 : 2 (14 +/- 0.5, 18 +/- 0.4 and 21 +/- 0.6 g/kg) and monounsaturated fatty acids (19 +/- 0.2, 15 +/- 1.2 and 10 +/- 1.3 g/kg). No effect of dietary treatment was observed on weight gain and feed consumption. A histological study of the jejunal mucosa showed lower cell desquamation in groups containing a supplemental level of alpha-tocopheryl acetate (p=0.080). A higher cell desquamation was found in the groups fed diets containing the higher concentration of C18 : 2 (p=0.087). We also observed an interaction effect (p < 0.001) of dietary fat source and vitamin E supplementation on jejunal cell desquamation in which the effect of dietary vitamin E was lower when diets with a low concentration of C18 : 2 were administered. In vitro-induced oxidation of jejunal mucosa homogenates was lower in pigs fed diets supplemented with alpha-tocopheryl acetate (p < 0.002). The dietary concentration of C18 : 2 significantly affected oxidation of pig jejunal mucosa (p < 0.002).

Authors+Show Affiliations

Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11686769

Citation

López Bote, C J., et al. "Effect of Dietary Linoleic Acid Concentration and Vitamin E Supplementation On Cell Desquamation and Susceptibility to Oxidative Damage of Pig Jejunal Mucosa." Journal of Animal Physiology and Animal Nutrition, vol. 85, no. 1-2, 2001, pp. 22-8.
López Bote CJ, Isabel B, Flores JM. Effect of dietary linoleic acid concentration and vitamin E supplementation on cell desquamation and susceptibility to oxidative damage of pig jejunal mucosa. J Anim Physiol Anim Nutr (Berl). 2001;85(1-2):22-8.
López Bote, C. J., Isabel, B., & Flores, J. M. (2001). Effect of dietary linoleic acid concentration and vitamin E supplementation on cell desquamation and susceptibility to oxidative damage of pig jejunal mucosa. Journal of Animal Physiology and Animal Nutrition, 85(1-2), 22-8.
López Bote CJ, Isabel B, Flores JM. Effect of Dietary Linoleic Acid Concentration and Vitamin E Supplementation On Cell Desquamation and Susceptibility to Oxidative Damage of Pig Jejunal Mucosa. J Anim Physiol Anim Nutr (Berl). 2001;85(1-2):22-8. PubMed PMID: 11686769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary linoleic acid concentration and vitamin E supplementation on cell desquamation and susceptibility to oxidative damage of pig jejunal mucosa. AU - López Bote,C J, AU - Isabel,B, AU - Flores,J M, PY - 2001/11/1/pubmed PY - 2002/1/5/medline PY - 2001/11/1/entrez SP - 22 EP - 8 JF - Journal of animal physiology and animal nutrition JO - J Anim Physiol Anim Nutr (Berl) VL - 85 IS - 1-2 N2 - Sixty Large White x Great York pigs weighing approximately 60 kg were individually fed on six experimental diets. The experiment was organized in a 3 x 2 factorial arrangement design with three different fat sources and a basal or supplemented (200 mg/kg diet) level of alpha-tocopheryl acetate. All diets contained the same concentration of saturated fatty acids (15 +/- 0.2 g/kg dry matter) but differed in the concentration of C18 : 2 (14 +/- 0.5, 18 +/- 0.4 and 21 +/- 0.6 g/kg) and monounsaturated fatty acids (19 +/- 0.2, 15 +/- 1.2 and 10 +/- 1.3 g/kg). No effect of dietary treatment was observed on weight gain and feed consumption. A histological study of the jejunal mucosa showed lower cell desquamation in groups containing a supplemental level of alpha-tocopheryl acetate (p=0.080). A higher cell desquamation was found in the groups fed diets containing the higher concentration of C18 : 2 (p=0.087). We also observed an interaction effect (p < 0.001) of dietary fat source and vitamin E supplementation on jejunal cell desquamation in which the effect of dietary vitamin E was lower when diets with a low concentration of C18 : 2 were administered. In vitro-induced oxidation of jejunal mucosa homogenates was lower in pigs fed diets supplemented with alpha-tocopheryl acetate (p < 0.002). The dietary concentration of C18 : 2 significantly affected oxidation of pig jejunal mucosa (p < 0.002). SN - 0931-2439 UR - https://www.unboundmedicine.com/medline/citation/11686769/Effect_of_dietary_linoleic_acid_concentration_and_vitamin_E_supplementation_on_cell_desquamation_and_susceptibility_to_oxidative_damage_of_pig_jejunal_mucosa_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0931-2439&amp;date=2001&amp;volume=85&amp;issue=1-2&amp;spage=22 DB - PRIME DP - Unbound Medicine ER -