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Autonomic nervous system function in patients with monogenic hypertension and brachydactyly: a field study in north-eastern Turkey.
J Hum Hypertens. 2001 Nov; 15(11):787-92.JH

Abstract

Laboratory studies in patients with autosomal-dominant hypertension and brachydactyly showed increased sensitivity to sympathetic stimuli and severe abnormalities in baroreflex buffering. To further elucidate the mechanisms by which impaired baroreflex sensitivity could influence blood pressure (BP), we conducted autonomic testing under field conditions. We studied 17 hypertensive affected (13 to 48 years, BMI 22.7 +/- 6.5 kg/m(2), 160 +/- 23/98 +/- 15 mm Hg) and 12 normotensive non-affected (9 to 60 years, BMI 24.0 +/- 4.7 kg/m(2), 120 +/- 16/70 +/- 10 mm Hg) family members. Pulse intervals and finger BP were measured using the Portapres device. Valsalva ratio, the blood pressure overshoot during phase IV of the Valsalva manoeuver, the Ewing coefficient (RR30/15 ratio), and heart rate and BP variability were similar in affected and non-affected family members. Overall, baroreflex sensitivity calculated using the cross-spectral (BRSLF, BRSHF) and sequence techniques (BRS+, BRS-) was not different between the groups. However, in younger family members, BRS+ was 12 +/- 3.7 and 22 +/- 13 msec/mm Hg in affected and in non-affected family members, respectively. The decline in BRS with age and with increasing blood pressure was absent in affected family members. We conclude that autonomic reflex testing conducted under field conditions is not impaired in patients with monogenic hypertension and brachydactyly. However, noninvasive testing showed impaired baroreflex control of heart rate at a young age. The reduced BRS in young family members with moderate arterial hypertension may suggest that the impaired baroreflex function is not secondary to the hypertension but rather a primary abnormality, which aggravates the progression of hypertension.

Authors+Show Affiliations

Clinical Research Center, Franz Volhard Clinic, Helios Kliniken-Berlin Medical Faculty of the Charité Humboldt-University, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11687923

Citation

Tank, J, et al. "Autonomic Nervous System Function in Patients With Monogenic Hypertension and Brachydactyly: a Field Study in North-eastern Turkey." Journal of Human Hypertension, vol. 15, no. 11, 2001, pp. 787-92.
Tank J, Toka O, Toka HR, et al. Autonomic nervous system function in patients with monogenic hypertension and brachydactyly: a field study in north-eastern Turkey. J Hum Hypertens. 2001;15(11):787-92.
Tank, J., Toka, O., Toka, H. R., Jordan, J., Diedrich, A., Busjahn, A., & Luft, F. C. (2001). Autonomic nervous system function in patients with monogenic hypertension and brachydactyly: a field study in north-eastern Turkey. Journal of Human Hypertension, 15(11), 787-92.
Tank J, et al. Autonomic Nervous System Function in Patients With Monogenic Hypertension and Brachydactyly: a Field Study in North-eastern Turkey. J Hum Hypertens. 2001;15(11):787-92. PubMed PMID: 11687923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic nervous system function in patients with monogenic hypertension and brachydactyly: a field study in north-eastern Turkey. AU - Tank,J, AU - Toka,O, AU - Toka,H R, AU - Jordan,J, AU - Diedrich,A, AU - Busjahn,A, AU - Luft,F C, PY - 2000/12/14/received PY - 2001/06/05/revised PY - 2001/06/13/accepted PY - 2001/11/1/pubmed PY - 2002/1/5/medline PY - 2001/11/1/entrez SP - 787 EP - 92 JF - Journal of human hypertension JO - J Hum Hypertens VL - 15 IS - 11 N2 - Laboratory studies in patients with autosomal-dominant hypertension and brachydactyly showed increased sensitivity to sympathetic stimuli and severe abnormalities in baroreflex buffering. To further elucidate the mechanisms by which impaired baroreflex sensitivity could influence blood pressure (BP), we conducted autonomic testing under field conditions. We studied 17 hypertensive affected (13 to 48 years, BMI 22.7 +/- 6.5 kg/m(2), 160 +/- 23/98 +/- 15 mm Hg) and 12 normotensive non-affected (9 to 60 years, BMI 24.0 +/- 4.7 kg/m(2), 120 +/- 16/70 +/- 10 mm Hg) family members. Pulse intervals and finger BP were measured using the Portapres device. Valsalva ratio, the blood pressure overshoot during phase IV of the Valsalva manoeuver, the Ewing coefficient (RR30/15 ratio), and heart rate and BP variability were similar in affected and non-affected family members. Overall, baroreflex sensitivity calculated using the cross-spectral (BRSLF, BRSHF) and sequence techniques (BRS+, BRS-) was not different between the groups. However, in younger family members, BRS+ was 12 +/- 3.7 and 22 +/- 13 msec/mm Hg in affected and in non-affected family members, respectively. The decline in BRS with age and with increasing blood pressure was absent in affected family members. We conclude that autonomic reflex testing conducted under field conditions is not impaired in patients with monogenic hypertension and brachydactyly. However, noninvasive testing showed impaired baroreflex control of heart rate at a young age. The reduced BRS in young family members with moderate arterial hypertension may suggest that the impaired baroreflex function is not secondary to the hypertension but rather a primary abnormality, which aggravates the progression of hypertension. SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/11687923/Autonomic_nervous_system_function_in_patients_with_monogenic_hypertension_and_brachydactyly:_a_field_study_in_north_eastern_Turkey_ L2 - https://doi.org/10.1038/sj.jhh.1001271 DB - PRIME DP - Unbound Medicine ER -