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Five-year incidence of angina pectoris and other forms of coronary heart disease in healthy men aged 50-59 in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study.

Abstract

BACKGROUND

The North-South gradient in myocardial infarction and coronary death rates in various western European regions has been described by the WHO MONICA Project over the last decade. The results of the 5-year follow-up of the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study reported here give the opportunity of extending the comparison to the incidence of angina pectoris in men aged 50-59 living in four regions (Belfast, Lille, Strasbourg, Toulouse) which were covered by the MONICA Project.

METHODS

The PRIME Study is a multicentre cohort study with a common protocol and centralized event analysis. It included 10 600 men, of whom 9758 (7359 in France and 2399 in Belfast) were free of coronary disease at entry with 842 (496 in France and 346 in Belfast) having pre-existing coronary disease.

RESULTS

In France, subjects free of coronary heart disease at baseline developed 106 cases of myocardial infarction or coronary death (2.93/1000 subjects per year) and 94 cases of angina pectoris (2.61/1000). In Belfast, 61 developed myocardial infarction or coronary death (5.24/1000) and 60 angina pectoris (5.39/1000). Hazard rate ratios for Belfast in comparison to France were respectively 1.79 (95% CI : 1.30-2.47) and 2.07 (1.49-2.86) for each class of clinical complication.

CONCLUSION

Rate ratios for angina pectoris incidence between Northern Ireland and France in the PRIME Study are comparable to those for myocardial infarction or coronary death reported by the WHO MONICA Project and suggest that the North-South gradient in Europe applies to different manifestations of coronary disease.

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  • Authors+Show Affiliations

    ,

    INSERM U258, Hôpital Paul Brousse, Villejuif, France.

    , , , ,

    Source

    International journal of epidemiology 30:5 2001 Oct pg 1057-62

    MeSH

    Angina Pectoris
    Coronary Disease
    France
    Humans
    Incidence
    Male
    Middle Aged
    Multicenter Studies as Topic
    Myocardial Infarction
    Northern Ireland

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11689522

    Citation

    Ducimetière, P, et al. "Five-year Incidence of Angina Pectoris and Other Forms of Coronary Heart Disease in Healthy Men Aged 50-59 in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study." International Journal of Epidemiology, vol. 30, no. 5, 2001, pp. 1057-62.
    Ducimetière P, Ruidavets JB, Montaye M, et al. Five-year incidence of angina pectoris and other forms of coronary heart disease in healthy men aged 50-59 in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study. Int J Epidemiol. 2001;30(5):1057-62.
    Ducimetière, P., Ruidavets, J. B., Montaye, M., Haas, B., & Yarnell, J. (2001). Five-year incidence of angina pectoris and other forms of coronary heart disease in healthy men aged 50-59 in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study. International Journal of Epidemiology, 30(5), pp. 1057-62.
    Ducimetière P, et al. Five-year Incidence of Angina Pectoris and Other Forms of Coronary Heart Disease in Healthy Men Aged 50-59 in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study. Int J Epidemiol. 2001;30(5):1057-62. PubMed PMID: 11689522.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Five-year incidence of angina pectoris and other forms of coronary heart disease in healthy men aged 50-59 in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study. AU - Ducimetière,P, AU - Ruidavets,J B, AU - Montaye,M, AU - Haas,B, AU - Yarnell,J, AU - ,, PY - 2001/11/2/pubmed PY - 2002/1/5/medline PY - 2001/11/2/entrez SP - 1057 EP - 62 JF - International journal of epidemiology JO - Int J Epidemiol VL - 30 IS - 5 N2 - BACKGROUND: The North-South gradient in myocardial infarction and coronary death rates in various western European regions has been described by the WHO MONICA Project over the last decade. The results of the 5-year follow-up of the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study reported here give the opportunity of extending the comparison to the incidence of angina pectoris in men aged 50-59 living in four regions (Belfast, Lille, Strasbourg, Toulouse) which were covered by the MONICA Project. METHODS: The PRIME Study is a multicentre cohort study with a common protocol and centralized event analysis. It included 10 600 men, of whom 9758 (7359 in France and 2399 in Belfast) were free of coronary disease at entry with 842 (496 in France and 346 in Belfast) having pre-existing coronary disease. RESULTS: In France, subjects free of coronary heart disease at baseline developed 106 cases of myocardial infarction or coronary death (2.93/1000 subjects per year) and 94 cases of angina pectoris (2.61/1000). In Belfast, 61 developed myocardial infarction or coronary death (5.24/1000) and 60 angina pectoris (5.39/1000). Hazard rate ratios for Belfast in comparison to France were respectively 1.79 (95% CI : 1.30-2.47) and 2.07 (1.49-2.86) for each class of clinical complication. CONCLUSION: Rate ratios for angina pectoris incidence between Northern Ireland and France in the PRIME Study are comparable to those for myocardial infarction or coronary death reported by the WHO MONICA Project and suggest that the North-South gradient in Europe applies to different manifestations of coronary disease. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/11689522/Five_year_incidence_of_angina_pectoris_and_other_forms_of_coronary_heart_disease_in_healthy_men_aged_50_59_in_France_and_Northern_Ireland:_the_Prospective_Epidemiological_Study_of_Myocardial_Infarction__PRIME__Study_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/30.5.1057 DB - PRIME DP - Unbound Medicine ER -