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Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator.
Clin Infect Dis. 2001 Dec 01; 33(11):1847-51.CI

Abstract

Treatment failures for leishmaniasis with pentavalent antimonials, including meglumine antimonate, are increasingly common in many endemic areas. Imiquimod (Aldara; 3M Pharmaceuticals) is a novel immune response-activating compound, approved by the United States Food and Drug Administration, that is currently used to treat cervical warts and has been shown to activate macrophage killing of Leishmania species. Therefore, an open-label, prospective study was conducted of combined imiquimod plus meglumine antimonate therapy in 12 patients with cutaneous leishmaniasis who had previously not responded to meglumine antimonate therapy. All of the patients responded well to this combination therapy, and 90% were found to be cured at the 6-month follow-up period.

Authors+Show Affiliations

Department of Microbiology and Immunology, McGill University, and Department of Tropical Medicine, McGill University Hospital Complex, Montreal, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11692295

Citation

Arevalo, I, et al. "Successful Treatment of Drug-resistant Cutaneous Leishmaniasis in Humans By Use of Imiquimod, an Immunomodulator." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 33, no. 11, 2001, pp. 1847-51.
Arevalo I, Ward B, Miller R, et al. Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator. Clin Infect Dis. 2001;33(11):1847-51.
Arevalo, I., Ward, B., Miller, R., Meng, T. C., Najar, E., Alvarez, E., Matlashewski, G., & Llanos-Cuentas, A. (2001). Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 33(11), 1847-51.
Arevalo I, et al. Successful Treatment of Drug-resistant Cutaneous Leishmaniasis in Humans By Use of Imiquimod, an Immunomodulator. Clin Infect Dis. 2001 Dec 1;33(11):1847-51. PubMed PMID: 11692295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator. AU - Arevalo,I, AU - Ward,B, AU - Miller,R, AU - Meng,T C, AU - Najar,E, AU - Alvarez,E, AU - Matlashewski,G, AU - Llanos-Cuentas,A, Y1 - 2001/10/23/ PY - 2001/04/03/received PY - 2001/06/28/revised PY - 2001/11/3/pubmed PY - 2002/1/5/medline PY - 2001/11/3/entrez SP - 1847 EP - 51 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 33 IS - 11 N2 - Treatment failures for leishmaniasis with pentavalent antimonials, including meglumine antimonate, are increasingly common in many endemic areas. Imiquimod (Aldara; 3M Pharmaceuticals) is a novel immune response-activating compound, approved by the United States Food and Drug Administration, that is currently used to treat cervical warts and has been shown to activate macrophage killing of Leishmania species. Therefore, an open-label, prospective study was conducted of combined imiquimod plus meglumine antimonate therapy in 12 patients with cutaneous leishmaniasis who had previously not responded to meglumine antimonate therapy. All of the patients responded well to this combination therapy, and 90% were found to be cured at the 6-month follow-up period. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/11692295/Successful_treatment_of_drug_resistant_cutaneous_leishmaniasis_in_humans_by_use_of_imiquimod_an_immunomodulator_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/324161 DB - PRIME DP - Unbound Medicine ER -