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Vitamin D control of osteoblast function and bone extracellular matrix mineralization.
Crit Rev Eukaryot Gene Expr. 2001; 11(1-3):199-226.CR

Abstract

Vitamin D is the major regulator of calcium homeostasis and protects the organism from calcium deficiency via effects on the intestine, kidney, parathyroid gland, and bone. Disturbances in the vitamin D endocrine system (e.g., vitamin D-dependent rickets type I and type II), result in profound effects on the mineralization of bone. Recent studies with vitamin D receptor knockout mice also show effects on bone. It is questioned whether vitamin D has a direct effect on bone formation and mineralization. In rickets and particular vitamin D receptor knockout mice, calcium supplementation restores bone mineralization. However, the vitamin D receptor is present in osteoblasts, and vitamin D affects the expression of various genes in osteoblasts. This review focuses on the role of vitamin D in the control of osteoblast function and discusses the current knowledge of the direct effects of vitamin D on mineralization. Moreover, the role of vitamin D metabolism and the mechanism of action of vitamin D and interaction with other hormones and factors are discussed.

Authors+Show Affiliations

Department of Internal Medicine, Erasmus Medical Center Rotterdam, The Netherlands. vanleeuwen@inw3.fgg.eur.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11693961

Citation

van Leeuwen, J P., et al. "Vitamin D Control of Osteoblast Function and Bone Extracellular Matrix Mineralization." Critical Reviews in Eukaryotic Gene Expression, vol. 11, no. 1-3, 2001, pp. 199-226.
van Leeuwen JP, van Driel M, van den Bemd GJ, et al. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit Rev Eukaryot Gene Expr. 2001;11(1-3):199-226.
van Leeuwen, J. P., van Driel, M., van den Bemd, G. J., & Pols, H. A. (2001). Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Critical Reviews in Eukaryotic Gene Expression, 11(1-3), 199-226.
van Leeuwen JP, et al. Vitamin D Control of Osteoblast Function and Bone Extracellular Matrix Mineralization. Crit Rev Eukaryot Gene Expr. 2001;11(1-3):199-226. PubMed PMID: 11693961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D control of osteoblast function and bone extracellular matrix mineralization. AU - van Leeuwen,J P, AU - van Driel,M, AU - van den Bemd,G J, AU - Pols,H A, PY - 2001/11/6/pubmed PY - 2002/4/9/medline PY - 2001/11/6/entrez SP - 199 EP - 226 JF - Critical reviews in eukaryotic gene expression JO - Crit. Rev. Eukaryot. Gene Expr. VL - 11 IS - 1-3 N2 - Vitamin D is the major regulator of calcium homeostasis and protects the organism from calcium deficiency via effects on the intestine, kidney, parathyroid gland, and bone. Disturbances in the vitamin D endocrine system (e.g., vitamin D-dependent rickets type I and type II), result in profound effects on the mineralization of bone. Recent studies with vitamin D receptor knockout mice also show effects on bone. It is questioned whether vitamin D has a direct effect on bone formation and mineralization. In rickets and particular vitamin D receptor knockout mice, calcium supplementation restores bone mineralization. However, the vitamin D receptor is present in osteoblasts, and vitamin D affects the expression of various genes in osteoblasts. This review focuses on the role of vitamin D in the control of osteoblast function and discusses the current knowledge of the direct effects of vitamin D on mineralization. Moreover, the role of vitamin D metabolism and the mechanism of action of vitamin D and interaction with other hormones and factors are discussed. SN - 1045-4403 UR - https://www.unboundmedicine.com/medline/citation/11693961/Vitamin_D_control_of_osteoblast_function_and_bone_extracellular_matrix_mineralization_ L2 - https://medlineplus.gov/vitamind.html DB - PRIME DP - Unbound Medicine ER -